ES8307755A1 - Un procedimiento para la preparacion de una composicion de derivados del imidazol. - Google Patents
Un procedimiento para la preparacion de una composicion de derivados del imidazol.Info
- Publication number
- ES8307755A1 ES8307755A1 ES513228A ES513228A ES8307755A1 ES 8307755 A1 ES8307755 A1 ES 8307755A1 ES 513228 A ES513228 A ES 513228A ES 513228 A ES513228 A ES 513228A ES 8307755 A1 ES8307755 A1 ES 8307755A1
- Authority
- ES
- Spain
- Prior art keywords
- diarrhoea
- treatment
- derivatives useful
- alkyl
- clonidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE COMPOSICIONES DE DERIVADOS DE IMIDAZOL QUE CONTIENE UN COMPUESTO DE FORMULA A-B-C, EN LA QUE A ES 2-IMIDAZOLINILO, QUE PUEDE ESTAR SUSTITUIDO CON GRUPO ALQUILO C<1<-<4, B ES OXIGENO, AZUFRE O VARIOS TIPOS DE RADICALES, Y C ES UN GRUPO CICLICO; Y UN VEHICULO FISIOLOGICAMENTE COMPATIBLE. CONSISTE EN LA REACCION DE ELIMINACION DE LOS RESTOS N-ACILO O SALINOS DE UN DERIVADO N-ACILADO O SALINO DEL COMPUESTO DE FORMULA A-B-C Y PREPARACION DE LA COMPOSICION. LA REACCION SE LLEVA A CABO POR TRATAMIENTO CON ACIDO CLORHIDRICO EN ETANOL ACUOSO AL 50%, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE DIARREA O PURGACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8022407 | 1980-07-09 | ||
GB8105339 | 1981-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES513228A0 ES513228A0 (es) | 1983-08-01 |
ES8307755A1 true ES8307755A1 (es) | 1983-08-01 |
Family
ID=26276158
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503790A Expired ES8301929A1 (es) | 1980-07-09 | 1981-07-08 | Un procedimiento para la preparacion de una composicion de derivados del imidazor. |
ES513228A Expired ES8307755A1 (es) | 1980-07-09 | 1982-06-17 | Un procedimiento para la preparacion de una composicion de derivados del imidazol. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503790A Expired ES8301929A1 (es) | 1980-07-09 | 1981-07-08 | Un procedimiento para la preparacion de una composicion de derivados del imidazor. |
Country Status (9)
Country | Link |
---|---|
US (2) | US4450170A (es) |
EP (1) | EP0043659B1 (es) |
JP (1) | JPS5740470A (es) |
AU (1) | AU547193B2 (es) |
CA (1) | CA1171418A (es) |
DE (1) | DE3168754D1 (es) |
ES (2) | ES8301929A1 (es) |
IE (1) | IE52021B1 (es) |
NZ (1) | NZ197530A (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
DE3360148D1 (en) * | 1982-02-10 | 1985-06-05 | Beecham Group Plc | Guanidine derivatives |
DE3363282D1 (de) * | 1982-09-16 | 1986-06-05 | Beecham Group Plc | Imidazoline derivatives |
US4444782A (en) * | 1982-12-23 | 1984-04-24 | Smithkline Beckman Corporation | 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent |
GB8304593D0 (en) * | 1983-02-18 | 1983-03-23 | Beecham Group Plc | Amidines |
FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
EP0134529B1 (de) * | 1983-08-17 | 1990-03-21 | Schering Aktiengesellschaft | 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
US4505926A (en) * | 1983-09-15 | 1985-03-19 | Beecham Group P.L.C. | Quaternary amino imidazolidines, compositions and use |
GB8333835D0 (en) * | 1983-12-20 | 1984-02-01 | Beecham Group Plc | Compounds |
US4801617A (en) * | 1987-04-06 | 1989-01-31 | Leclerc Gerard | Iminoimidazolidines useful in lowering intraocular pressure |
US4897412A (en) * | 1987-04-06 | 1990-01-30 | Laboratories Alcon S.A. | Imidazolines useful in lowering intraocular pressure |
GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
US5369095A (en) * | 1990-02-14 | 1994-11-29 | Alcon Laboratories, Inc. | Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers |
US5869458A (en) * | 1994-10-14 | 1999-02-09 | Waite; Christopher S. | Frozen rehydration formulation and delivery system therefor |
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
US6572898B2 (en) | 1999-05-21 | 2003-06-03 | Pts Labs Llc | Electrolyte gels for maintaining hydration and rehydration |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
BR112017022321B1 (pt) * | 2015-04-17 | 2023-03-14 | Monopar Therapeutics Inc | Uso de clonidina e/ou de um derivado de clonidina para o tratamento de astenia e/ou fadiga devido a quimioterapia de agente alquilante |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3190802A (en) * | 1961-10-09 | 1965-06-22 | Boehringer Sohn Ingelheim | Shaving composition and method of using same |
DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2806811A1 (de) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben |
EP0025269B1 (en) * | 1979-08-23 | 1985-11-13 | Beecham Group Plc | Anti-diarrhoea veterinary composition |
US4265900A (en) * | 1979-10-29 | 1981-05-05 | Mcneilab, Inc. | N-Aryl-N'-imidazol-2-ylureas |
DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
US4312879A (en) * | 1980-08-14 | 1982-01-26 | Richardson-Merrell Inc. | Clonidine and lofexidine as antidiarrheal agents |
-
1981
- 1981-06-17 DE DE8181302710T patent/DE3168754D1/de not_active Expired
- 1981-06-17 EP EP81302710A patent/EP0043659B1/en not_active Expired
- 1981-06-24 US US06/277,034 patent/US4450170A/en not_active Expired - Fee Related
- 1981-06-25 NZ NZ197530A patent/NZ197530A/en unknown
- 1981-07-08 IE IE1541/81A patent/IE52021B1/en unknown
- 1981-07-08 CA CA000381322A patent/CA1171418A/en not_active Expired
- 1981-07-08 JP JP56106830A patent/JPS5740470A/ja active Pending
- 1981-07-08 ES ES503790A patent/ES8301929A1/es not_active Expired
- 1981-07-08 AU AU72646/81A patent/AU547193B2/en not_active Ceased
-
1982
- 1982-06-17 ES ES513228A patent/ES8307755A1/es not_active Expired
-
1984
- 1984-02-27 US US06/584,015 patent/US4558063A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES503790A0 (es) | 1982-11-01 |
US4558063A (en) | 1985-12-10 |
US4450170A (en) | 1984-05-22 |
DE3168754D1 (en) | 1985-03-21 |
EP0043659A1 (en) | 1982-01-13 |
JPS5740470A (en) | 1982-03-06 |
EP0043659B1 (en) | 1985-02-06 |
IE811541L (en) | 1982-01-09 |
AU7264681A (en) | 1982-01-14 |
NZ197530A (en) | 1985-05-31 |
CA1171418A (en) | 1984-07-24 |
ES513228A0 (es) | 1983-08-01 |
IE52021B1 (en) | 1987-05-27 |
ES8301929A1 (es) | 1982-11-01 |
AU547193B2 (en) | 1985-10-10 |
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