ES8301929A1 - Un procedimiento para la preparacion de una composicion de derivados del imidazor. - Google Patents

Un procedimiento para la preparacion de una composicion de derivados del imidazor.

Info

Publication number
ES8301929A1
ES8301929A1 ES503790A ES503790A ES8301929A1 ES 8301929 A1 ES8301929 A1 ES 8301929A1 ES 503790 A ES503790 A ES 503790A ES 503790 A ES503790 A ES 503790A ES 8301929 A1 ES8301929 A1 ES 8301929A1
Authority
ES
Spain
Prior art keywords
diarrhoea
treatment
derivatives useful
alkyl
clonidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503790A
Other languages
English (en)
Other versions
ES503790A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES503790A0 publication Critical patent/ES503790A0/es
Publication of ES8301929A1 publication Critical patent/ES8301929A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION DE DERIVADOS DE IMIDAZOL, QUE CONSTA DE UN COMPUESTO DE FORMULA A-B-C, EN LA QUE A ES 2-IMIDAZOLINILO; C ES UN GRUPO CARBOCICLICO O HETEROCICLICO C <003> ; Y B PUEDE SER VARIOS RADICALES, Y DE UN VEHICULO FISIOLOGICAMENTE COMPATIBLE. CONSISTE EN LA REACCION DEL COMPUESTO DE FORMULA A-B-C, EN LA QUE A, B Y C TIENEN EL SIGNIFICADO ANTERIOR CON UN COMPUESTO CAPAZ DE INTRODUCIR UN RESTO ACILO EN UNO O VARIOS DE LOS ATOMOS DE NITROGENO DISPONIBLES, O DE FORMAR UNA SAL DE DICHO COMPUESTO; Y ASOCIAR EL PRODUCTO OBTENIDO CON UN PORTADOR. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE DIARREA.
ES503790A 1980-07-09 1981-07-08 Un procedimiento para la preparacion de una composicion de derivados del imidazor. Expired ES8301929A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8022407 1980-07-09
GB8105339 1981-02-20

Publications (2)

Publication Number Publication Date
ES503790A0 ES503790A0 (es) 1982-11-01
ES8301929A1 true ES8301929A1 (es) 1982-11-01

Family

ID=26276158

Family Applications (2)

Application Number Title Priority Date Filing Date
ES503790A Expired ES8301929A1 (es) 1980-07-09 1981-07-08 Un procedimiento para la preparacion de una composicion de derivados del imidazor.
ES513228A Expired ES8307755A1 (es) 1980-07-09 1982-06-17 Un procedimiento para la preparacion de una composicion de derivados del imidazol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES513228A Expired ES8307755A1 (es) 1980-07-09 1982-06-17 Un procedimiento para la preparacion de una composicion de derivados del imidazol.

Country Status (9)

Country Link
US (2) US4450170A (es)
EP (1) EP0043659B1 (es)
JP (1) JPS5740470A (es)
AU (1) AU547193B2 (es)
CA (1) CA1171418A (es)
DE (1) DE3168754D1 (es)
ES (2) ES8301929A1 (es)
IE (1) IE52021B1 (es)
NZ (1) NZ197530A (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea
EP0070084A3 (en) * 1981-04-24 1983-02-16 Beecham Group Plc Imidazoline derivatives
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US4644007A (en) * 1981-11-20 1987-02-17 Alcon Laboratories, Inc. 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
DE3360148D1 (en) * 1982-02-10 1985-06-05 Beecham Group Plc Guanidine derivatives
EP0107306B1 (en) * 1982-09-16 1986-04-30 Beecham Group Plc Imidazoline derivatives
US4444782A (en) * 1982-12-23 1984-04-24 Smithkline Beckman Corporation 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent
GB8304593D0 (en) * 1983-02-18 1983-03-23 Beecham Group Plc Amidines
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4505926A (en) * 1983-09-15 1985-03-19 Beecham Group P.L.C. Quaternary amino imidazolidines, compositions and use
GB8333835D0 (en) * 1983-12-20 1984-02-01 Beecham Group Plc Compounds
US4801617A (en) * 1987-04-06 1989-01-31 Leclerc Gerard Iminoimidazolidines useful in lowering intraocular pressure
US4897412A (en) * 1987-04-06 1990-01-30 Laboratories Alcon S.A. Imidazolines useful in lowering intraocular pressure
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
US5369095A (en) * 1990-02-14 1994-11-29 Alcon Laboratories, Inc. Compositions and method comprising substituted glycosides as mucus membrane permeation enhancers
US5869458A (en) * 1994-10-14 1999-02-09 Waite; Christopher S. Frozen rehydration formulation and delivery system therefor
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
US6572898B2 (en) 1999-05-21 2003-06-03 Pts Labs Llc Electrolyte gels for maintaining hydration and rehydration
PE20070182A1 (es) 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
WO2016165775A1 (en) 2015-04-17 2016-10-20 Onxeo Clonidine and/or clonidine derivatives for use in the prevention and/or treatment of adverse side effects of chemotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202660A (en) * 1961-10-09 1965-08-24 Boehringer Sohn Ingelheim Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
DE1670274A1 (de) * 1966-10-31 1970-07-16 Boehringer Sohn Ingelheim Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2)
AT285599B (de) * 1968-06-21 1970-11-10 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2806811A1 (de) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben
EP0025269B1 (en) * 1979-08-23 1985-11-13 Beecham Group Plc Anti-diarrhoea veterinary composition
US4265900A (en) * 1979-10-29 1981-05-05 Mcneilab, Inc. N-Aryl-N'-imidazol-2-ylureas
DE3168754D1 (en) * 1980-07-09 1985-03-21 Beecham Group Plc Clonidine derivatives useful in the treatment of diarrhoea
US4312879A (en) * 1980-08-14 1982-01-26 Richardson-Merrell Inc. Clonidine and lofexidine as antidiarrheal agents

Also Published As

Publication number Publication date
IE811541L (en) 1982-01-09
ES503790A0 (es) 1982-11-01
CA1171418A (en) 1984-07-24
US4450170A (en) 1984-05-22
ES513228A0 (es) 1983-08-01
AU547193B2 (en) 1985-10-10
JPS5740470A (en) 1982-03-06
EP0043659B1 (en) 1985-02-06
US4558063A (en) 1985-12-10
ES8307755A1 (es) 1983-08-01
AU7264681A (en) 1982-01-14
DE3168754D1 (en) 1985-03-21
NZ197530A (en) 1985-05-31
IE52021B1 (en) 1987-05-27
EP0043659A1 (en) 1982-01-13

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