ES8306740A1 - Un procedimiento para la preparacion de 1-(3-halo-2-piridinil)piperazinas. - Google Patents
Un procedimiento para la preparacion de 1-(3-halo-2-piridinil)piperazinas.Info
- Publication number
- ES8306740A1 ES8306740A1 ES512533A ES512533A ES8306740A1 ES 8306740 A1 ES8306740 A1 ES 8306740A1 ES 512533 A ES512533 A ES 512533A ES 512533 A ES512533 A ES 512533A ES 8306740 A1 ES8306740 A1 ES 8306740A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridinyl
- halo
- piperazines
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE 1-(3-HALO-2-PIRIDINIL)PIPERACINAS. SE HACE REACCIONAR UNA 3-HALOPIRIDINA DE FORMULA ESTRUCTURAL (I) DONDE HALO ES CLORO, BROMO O FLUOR E Y ES FLUOR, CLORO, BROMO, YODO ALQUILSULFONILOXI C <- , ARILSULFONILOXI BENCENOIDE, ALQUILSULFONILO C <- O ARILSULFONILO BENCENOIDE, CON UN COMPUESTO DE FORMULA ESTRUCTURAL (II), A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y UNOS 200 C, EN ATMOSFERA DE GAS INERTE, TAL COMO NITROGENO, HELIO O ARGON, PARA DAR UN COMPUESTO DE FORMULA ESTRUCTURAL (IV) Y DURANTE UN PERIODO DE TIEMPO DE 0,5 A 3 DIAS. LA REACCION PUEDE LLEVARSE A CABO SIN DISOLVENTE, O EN UN DISOLVENTE ORGANICO INERTE, TAL COMO UN ALCANOL C <- . SE UTILIZAN COMO AGENTES ANTIDEPRESIVOS Y PARA EL TRATAMIENTO DE LA SEDACION CAUSADA POR UNA TERAPIA ANTIHIPERTENSIVA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26712081A | 1981-05-26 | 1981-05-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8306740A1 true ES8306740A1 (es) | 1983-06-01 |
ES512533A0 ES512533A0 (es) | 1983-06-01 |
Family
ID=23017399
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512533A Granted ES512533A0 (es) | 1981-05-26 | 1982-05-25 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil)piperazinas. |
ES519854A Granted ES519854A0 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
ES519856A Expired ES8403477A1 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
ES519855A Expired ES8403476A1 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES519854A Granted ES519854A0 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
ES519856A Expired ES8403477A1 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
ES519855A Expired ES8403476A1 (es) | 1981-05-26 | 1983-02-16 | Un procedimiento para la preparacion de 1-(3-halo-2-piridinil) piperazinas. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0065757B1 (es) |
JP (1) | JPS6055068B2 (es) |
AT (1) | ATE11134T1 (es) |
AU (1) | AU547319B2 (es) |
CA (1) | CA1214467A (es) |
DE (1) | DE3261827D1 (es) |
DK (1) | DK234282A (es) |
ES (4) | ES512533A0 (es) |
FI (1) | FI821739A0 (es) |
GR (1) | GR76413B (es) |
IE (1) | IE53035B1 (es) |
IL (1) | IL65802A (es) |
NO (1) | NO821730L (es) |
NZ (1) | NZ200642A (es) |
PH (1) | PH18686A (es) |
PT (1) | PT74926B (es) |
ZA (1) | ZA823611B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH056685U (ja) * | 1991-07-09 | 1993-01-29 | 株式会社ユアサコーポレーシヨン | 電池の艤装構造 |
US7345096B2 (en) | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
US20040152710A1 (en) * | 2002-10-15 | 2004-08-05 | Deecher Darlene Coleman | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
US7419980B2 (en) | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7531543B2 (en) | 2003-10-14 | 2009-05-12 | Wyeth | Phenylpiperazine cycloalkanol derivatives and methods of their use |
US7402698B2 (en) | 2003-10-14 | 2008-07-22 | Wyeth | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use |
US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
US7524846B2 (en) | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
CN101671297B (zh) * | 2008-09-11 | 2012-05-09 | 上海药明康德新药开发有限公司 | 4-(3-碘-2-吡啶基)哌嗪类化合物的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773951A (en) * | 1972-12-21 | 1973-11-20 | Miles Lab | Method of treating depression with 1-(2-pyridyl)piperazine |
US4078063A (en) * | 1976-09-24 | 1978-03-07 | Merck & Co., Inc. | Piperazinylpyridines |
-
1982
- 1982-05-12 PH PH27279A patent/PH18686A/en unknown
- 1982-05-17 NZ NZ200642A patent/NZ200642A/en unknown
- 1982-05-17 FI FI821739A patent/FI821739A0/fi not_active Application Discontinuation
- 1982-05-17 IL IL65802A patent/IL65802A/xx unknown
- 1982-05-18 PT PT74926A patent/PT74926B/pt unknown
- 1982-05-18 AU AU83802/82A patent/AU547319B2/en not_active Ceased
- 1982-05-19 DE DE8282104398T patent/DE3261827D1/de not_active Expired
- 1982-05-19 EP EP82104398A patent/EP0065757B1/en not_active Expired
- 1982-05-19 AT AT82104398T patent/ATE11134T1/de not_active IP Right Cessation
- 1982-05-21 IE IE1225/82A patent/IE53035B1/en unknown
- 1982-05-24 GR GR68235A patent/GR76413B/el unknown
- 1982-05-25 NO NO821730A patent/NO821730L/no unknown
- 1982-05-25 CA CA000403610A patent/CA1214467A/en not_active Expired
- 1982-05-25 ES ES512533A patent/ES512533A0/es active Granted
- 1982-05-25 DK DK234282A patent/DK234282A/da not_active Application Discontinuation
- 1982-05-25 ZA ZA823611A patent/ZA823611B/xx unknown
- 1982-05-26 JP JP57088171A patent/JPS6055068B2/ja not_active Expired
-
1983
- 1983-02-16 ES ES519854A patent/ES519854A0/es active Granted
- 1983-02-16 ES ES519856A patent/ES8403477A1/es not_active Expired
- 1983-02-16 ES ES519855A patent/ES8403476A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU547319B2 (en) | 1985-10-17 |
CA1214467A (en) | 1986-11-25 |
PT74926B (en) | 1985-05-16 |
ES8403475A1 (es) | 1984-03-16 |
IL65802A0 (en) | 1982-08-31 |
PH18686A (en) | 1985-08-29 |
DE3261827D1 (en) | 1985-02-21 |
ES519854A0 (es) | 1984-03-16 |
ZA823611B (en) | 1983-12-28 |
ES519855A0 (es) | 1984-03-16 |
GR76413B (es) | 1984-08-10 |
ES519856A0 (es) | 1984-03-16 |
IE53035B1 (en) | 1988-05-11 |
ES8403476A1 (es) | 1984-03-16 |
EP0065757A1 (en) | 1982-12-01 |
AU8380282A (en) | 1982-12-02 |
EP0065757B1 (en) | 1985-01-09 |
PT74926A (en) | 1982-06-01 |
JPS584766A (ja) | 1983-01-11 |
FI821739A0 (fi) | 1982-05-17 |
IE821225L (en) | 1982-11-26 |
JPS6055068B2 (ja) | 1985-12-03 |
IL65802A (en) | 1985-12-31 |
NO821730L (no) | 1982-11-29 |
NZ200642A (en) | 1984-11-09 |
ATE11134T1 (de) | 1985-01-15 |
DK234282A (da) | 1982-11-27 |
ES8403477A1 (es) | 1984-03-16 |
ES512533A0 (es) | 1983-06-01 |
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