ES8305322A1 - "procedimiento de obtencion de n,n,-diacetil cisteina". - Google Patents

"procedimiento de obtencion de n,n,-diacetil cisteina".

Info

Publication number
ES8305322A1
ES8305322A1 ES510320A ES510320A ES8305322A1 ES 8305322 A1 ES8305322 A1 ES 8305322A1 ES 510320 A ES510320 A ES 510320A ES 510320 A ES510320 A ES 510320A ES 8305322 A1 ES8305322 A1 ES 8305322A1
Authority
ES
Spain
Prior art keywords
cysteine
compound
acetyl
preparation
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510320A
Other languages
English (en)
Other versions
ES510320A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Especialidades Latinas Medicamentos Universales SA
Original Assignee
Especialidades Latinas Medicamentos Universales SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Especialidades Latinas Medicamentos Universales SA filed Critical Especialidades Latinas Medicamentos Universales SA
Priority to ES510320A priority Critical patent/ES8305322A1/es
Priority to PT76148A priority patent/PT76148B/pt
Priority to BR8300798A priority patent/BR8300798A/pt
Priority to DE19833307236 priority patent/DE3307236A1/de
Priority to FR8303958A priority patent/FR2523127A1/fr
Priority to IT47886/83A priority patent/IT1165580B/it
Publication of ES510320A0 publication Critical patent/ES510320A0/es
Publication of ES8305322A1 publication Critical patent/ES8305322A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE N,S-DIACETIL CISTEINA. CONSISTE EN DISOLVER LA CISTEINA CLORHIDRATO O LA BASE LIBRE CORRESPONDIENTE EN HIDROXIDO SODICO A UNA TEMPERATURA NO SUPERIOR A 15 C. A LA SOLUCION OBTENIDA, SE AÑADE LENTAMENTE ANHIDRIDO ACETICO A TEMPERATURAS COMPRENDIDAS ENTRE -5 Y 5 C, MANTENIENDO LA MEZCLA EN AGITACION DURANTE 2 O 3 HORAS Y DESPUES EN REPOSO DURANTE UNA NOCHE A TEMPERATURA INFERIOR A 0 C. LA MEZCLA SE EXTRAE CON ACETATO DE ETILO Y EL EXTRACTO ORGANICO SE SECA CON SULFATO SODICO ANHIDRIDO Y SE SECA A SEQUEDAD A VACIO. EL RESIDUO SODICO ES LAVADO CON ETER ETILICO.
ES510320A 1982-03-11 1982-03-11 "procedimiento de obtencion de n,n,-diacetil cisteina". Expired ES8305322A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES510320A ES8305322A1 (es) 1982-03-11 1982-03-11 "procedimiento de obtencion de n,n,-diacetil cisteina".
PT76148A PT76148B (en) 1982-03-11 1983-01-27 Process for the preparation of n,s-diacetyl cysteine having mucolytic and secretolytic properties
BR8300798A BR8300798A (pt) 1982-03-11 1983-02-18 Processo de obtencao de m, s, - diacetilcisteina
DE19833307236 DE3307236A1 (de) 1982-03-11 1983-03-02 N,s-di-(acetyl)cystein, verfahren zu dessen herstellung und diese verbindung enthaltene arzneimittel
FR8303958A FR2523127A1 (fr) 1982-03-11 1983-03-10 N,s-diacetylcysteine utile notamment comme agent mucolytique, son procede de fabrication et compositions pharmaceutiques la contenant
IT47886/83A IT1165580B (it) 1982-03-11 1983-03-10 N.s-diacetilcisteina e procedimento per la sua preparazione

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES510320A ES8305322A1 (es) 1982-03-11 1982-03-11 "procedimiento de obtencion de n,n,-diacetil cisteina".

Publications (2)

Publication Number Publication Date
ES510320A0 ES510320A0 (es) 1983-04-01
ES8305322A1 true ES8305322A1 (es) 1983-04-01

Family

ID=8483811

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510320A Expired ES8305322A1 (es) 1982-03-11 1982-03-11 "procedimiento de obtencion de n,n,-diacetil cisteina".

Country Status (6)

Country Link
BR (1) BR8300798A (es)
DE (1) DE3307236A1 (es)
ES (1) ES8305322A1 (es)
FR (1) FR2523127A1 (es)
IT (1) IT1165580B (es)
PT (1) PT76148B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34414E (en) * 1982-10-20 1993-10-19 Takeda Chemical Industries, Ltd. Physiologically active substance P-23924, its production and use
DE3378909D1 (en) * 1982-10-20 1989-02-16 Takeda Chemical Industries Ltd Physiologically active substance p-23924, its production and use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4619M (es) * 1965-02-01 1966-11-28

Also Published As

Publication number Publication date
IT1165580B (it) 1987-04-22
DE3307236A1 (de) 1983-10-13
PT76148A (en) 1983-02-01
IT8347886A0 (it) 1983-03-10
ES510320A0 (es) 1983-04-01
BR8300798A (pt) 1983-11-16
PT76148B (en) 1985-11-25
FR2523127A1 (fr) 1983-09-16

Similar Documents

Publication Publication Date Title
ES472608A1 (es) Un procedimiento de preparacion de derivados de 4-n-acilo- fortimicina b
IL71958A0 (en) Process for the preparation of phosphorus-containing cyanohydrin derivatives
ES8305322A1 (es) "procedimiento de obtencion de n,n,-diacetil cisteina".
AU565492B2 (en) 4-phenyl-4-oxo-buten-2-oic acids
IL74114A (en) Process for the preparation of alkanephosphonous acids
HK1005179A1 (en) Substituted 3,4-dihydronaphthalenes medicament containing them and process for their preparation
IE822391L (en) 4-acylamino-1-azaadamantanes
JPS5212109A (en) Process for preparation of alkylglycerylether
GB1478281A (en) 11,12-secoprostaglandins
SE7805273L (sv) Salt
GB1317205A (en) Propargyl ethers and a process for the preparation thereof
JPS5422350A (en) Purification of aromatic polyamines
JPS53119820A (en) Preparation of alkali aminodiacetate
KR920019742A (ko) L-프롤린 유도체의 제조방법
JPS5686178A (en) Preparation of triglycidylaminophenol
ES8305210A1 (es) Procedimiento de preparacion de eteres de fenoles.
ES449610A1 (es) Un procedimiento de preparacion de compuestos derivados de la midecamicina.
GB2008097A (en) Method for producing 2,2,4- trimethyl-3- hydroxypentyl isobutyrate
AT383811B (de) Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten
JPS56128769A (en) Amino-5-fluorouracil derivative and its preparation
GB1541185A (en) 5-fluorouracil derivatives and their preparation
GB763217A (en) Colchiceine derivatives
JPS5598177A (en) Novel 3-hydroxyphthalide derivative
ES8206510A1 (es) Procedimiento para la preparacion del compuesto 3-metil-3- (o-metoxi-fenoxi)-benzo-2,4-dioxaciclohexanona
JPS5279081A (en) Preparation of novel 7-methoxycephalosporins