ES8304578A1 - New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof - Google Patents

New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof

Info

Publication number
ES8304578A1
ES8304578A1 ES509825A ES509825A ES8304578A1 ES 8304578 A1 ES8304578 A1 ES 8304578A1 ES 509825 A ES509825 A ES 509825A ES 509825 A ES509825 A ES 509825A ES 8304578 A1 ES8304578 A1 ES 8304578A1
Authority
ES
Spain
Prior art keywords
preparation
alkyl
pharmaceutical compositions
ergoline derivatives
new ergoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509825A
Other languages
Spanish (es)
Other versions
ES509825A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH121081A external-priority patent/CH645894A5/en
Priority claimed from CH121181A external-priority patent/CH645895A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES509825A0 publication Critical patent/ES509825A0/en
Publication of ES8304578A1 publication Critical patent/ES8304578A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D457/00Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The compounds have the formula I (FORMULA) wherein R<u1>u is H, a C<u1-4>u alkyl or their precursors, R<u2>u is a C<u1-4>u alkyl, R<u3>u and R<u4>u independently of each other are H, a C alkyl or together are a C alkylene, R<u5>u is H or alkyl and A and B are each H or together represent a bond, providing that, when R<u1>u and R<u2>u = CH<u3>u, R<u3>u and R<u4>u = C<u2>uH<u5>u, A and B = H, R<u5>u is alkyl. Are also concerned the acid addition salts of those compounds. The compounds are used for the treatment of hypertonus, and cardiac insufficiencies.
ES509825A 1981-02-24 1982-02-23 New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof Expired ES8304578A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH121081A CH645894A5 (en) 1981-02-24 1981-02-24 Ergoline derivatives, their preparation and use
CH121181A CH645895A5 (en) 1981-02-24 1981-02-24 Ergoline derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
ES509825A0 ES509825A0 (en) 1983-03-01
ES8304578A1 true ES8304578A1 (en) 1983-03-01

Family

ID=25687002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509825A Expired ES8304578A1 (en) 1981-02-24 1982-02-23 New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof

Country Status (16)

Country Link
AU (1) AU8068282A (en)
CA (1) CA1178582A (en)
DE (1) DE3205169A1 (en)
DK (1) DK77082A (en)
ES (1) ES8304578A1 (en)
FI (1) FI820526L (en)
FR (1) FR2500454A1 (en)
GB (1) GB2093452B (en)
HU (1) HU187650B (en)
IL (1) IL65074A0 (en)
NL (1) NL8200694A (en)
NZ (1) NZ199795A (en)
PH (1) PH17494A (en)
PT (1) PT74468B (en)
SE (1) SE8201098L (en)
WO (1) WO1982002892A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (en) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen NEW ERGOLIN DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE AS A MEDICINAL PRODUCT
DE3402392A1 (en) * 1984-01-25 1985-08-01 Sandoz-Patent-GmbH, 7850 Lörrach NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND THEIR USE
DE3445784A1 (en) * 1984-12-13 1986-06-26 Schering AG, Berlin und Bergkamen, 1000 Berlin METHOD FOR PRODUCING ERGOLIN DERIVATIVES
DE3528576A1 (en) * 1985-08-06 1987-02-19 Schering Ag METHOD FOR THE PRODUCTION OF ERGOLIN THIOUROS
DE3528584A1 (en) * 1985-08-06 1987-02-19 Schering Ag NEW 1-ALKYL-ERGOLIN-THIOURINE DERIVATIVES
DE3533672A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-SUBSTITUTED ERGOL DERIVATIVES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646046A (en) * 1968-03-07 1972-02-29 Farmaceutici Italia 1 6-dimethyl-10alpha-ergoline derivatives
DK140596B (en) * 1971-05-19 1979-10-08 Sandoz Ag Analogous process for the preparation of 8beta- (ureidomethyl) -ergolene derivatives.
CH628049A5 (en) * 1977-03-25 1982-02-15 Sandoz Ag Process for the preparation of ergolene derivatives
FR2421176A1 (en) * 1978-03-29 1979-10-26 Sandoz Sa 2,3-Di:hydro-ergolenyl-methyl urea derivs. - useful as antihypertensives

Also Published As

Publication number Publication date
NL8200694A (en) 1982-09-16
WO1982002892A1 (en) 1982-09-02
PH17494A (en) 1984-09-04
ES509825A0 (en) 1983-03-01
GB2093452B (en) 1984-11-07
SE8201098L (en) 1982-08-25
IL65074A0 (en) 1982-04-30
DK77082A (en) 1982-08-25
NZ199795A (en) 1985-08-30
DE3205169A1 (en) 1982-10-14
HU187650B (en) 1986-02-28
PT74468B (en) 1984-08-01
CA1178582A (en) 1984-11-27
GB2093452A (en) 1982-09-02
PT74468A (en) 1982-03-01
FR2500454A1 (en) 1982-08-27
FI820526L (en) 1982-08-25
AU8068282A (en) 1982-09-02
FR2500454B1 (en) 1984-11-09

Similar Documents

Publication Publication Date Title
ES8203883A1 (en) Imidazole derivatives, their preparation and compositions containing them.
IL75583A0 (en) Pyrazole analogs of mevalonolactone and derivatives thereof,their preparation and pharmaceutical compositions containing them
ES8609204A1 (en) Phenylisopropylamine derivative and its preparation.
IL77717A (en) Pharmaceutical compositions containing derivatives of imidazole,their preparation and some novel compounds of this type
ES8306371A1 (en) Stable S-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle.
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
NO855241L (en) PROCEDURE FOR THE PREPARATION OF CARBAPEN COMPOUNDS.
ES8504682A1 (en) New nitro aliphatic compounds, process for preparation thereof and use thereof.
ES8304578A1 (en) New ergoline derivatives,preparation thereof and pharmaceutical compositions thereof
DE3069381D1 (en) Amino substituted tetrahydrobenzindoles, a process for preparing and a pharmaceutical composition containing the same
ATE38028T1 (en) CYCLOALIPHATIC MEDICINAL COMPOSITIONS.
IE792329L (en) Thiazaheterocyclics and process for preparing pyrrolidine¹and piperidine derivatives.
ES477785A1 (en) 2-Phenylimino-imidazolidines and salts thereof
IL82181A0 (en) 1,5-benzothiazepine derivatives,their preparation and compositions containing them
GB1505899A (en) 3,4-dihydrocarbostyril derivatives
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
EP0173377A3 (en) Pyrimidone compounds, their preparation and pharmaceutical compositions containing them
DK422183D0 (en) PROCEDURE FOR PREPARING 5-HALOGENVINYL-2 &#39;-DEOXYURIDE INGREDIATES
ES8201979A1 (en) Biphenylyl-imidazolylethane derivatives, process for their preparation and medicaments containing them.
GB1292787A (en) Benzodioxane derivatives and pharmaceutical compositions containing them
ES543793A0 (en) PROCEDURE FOR THE PREPARATION OF NEW A-ETILBEN-ZOL DERIVATIVES WITH A SUBSTITUTED PIPERIDINOPROPANOLIC GROUP AND ITS QUADRONARY AMONIC AND ACID ADDITIONAL SALTS
ES8205219A1 (en) Hydrouracil compounds.
ES556048A0 (en) A PROCEDURE FOR THE PREPARATION OF A THIAZOLIDINE DERIVATIVE.
ES2001440A6 (en) Catechol derivatives, a process of preparation thereof, and therapeutical compositions containing the same
ES8201575A1 (en) Novel 2-aminoethanol, manufacture and hypotensive and analgesic medicine containing same

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402