ES8304538A1 - Chemical Compounds - Google Patents
Chemical CompoundsInfo
- Publication number
- ES8304538A1 ES8304538A1 ES512915A ES512915A ES8304538A1 ES 8304538 A1 ES8304538 A1 ES 8304538A1 ES 512915 A ES512915 A ES 512915A ES 512915 A ES512915 A ES 512915A ES 8304538 A1 ES8304538 A1 ES 8304538A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydrogen atom
- optionally substituted
- methylene
- optical isomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxymethylene group Chemical group 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B23/00—Record carriers not specific to the method of recording or reproducing; Accessories, e.g. containers, specially adapted for co-operation with the recording or reproducing apparatus ; Intermediate mediums; Apparatus or processes specially adapted for their manufacture
- G11B23/02—Containers; Storing means both adapted to cooperate with the recording or reproducing means
- G11B23/04—Magazines; Cassettes for webs or filaments
- G11B23/08—Magazines; Cassettes for webs or filaments for housing webs or filaments having two distinct ends
- G11B23/087—Magazines; Cassettes for webs or filaments for housing webs or filaments having two distinct ends using two different reels or cores
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B25/00—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus
- G11B25/06—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus using web-form record carriers, e.g. tape
- G11B25/066—Apparatus characterised by the shape of record carrier employed but not specific to the method of recording or reproducing, e.g. dictating apparatus; Combinations of such apparatus using web-form record carriers, e.g. tape adapted for use with containers of different sizes or configurations; adaptor devices therefor
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Compounds of general formula I < IMAGE > wherein R1 represents a hydroxy group or an optionally substituted amino group R2 and R3 each represents a halogen atom, a trifluoromethyl, cyano or nitro group or one of the radicals R2 or R3 represents a hydrogen atom R4 represents a hydrogen atom or an alkyl group R5 represents a hydrogen atom, an alkyl, cycloalkyl, alkenyl or aralkyl group A represents a methylene, ethylene or hydroxymethylene group and B represents an optionally substituted aralkyl group, in which the methylene group adjacent to the phenyl nucleus may be replaced by an oxygen or sulfur atom, or a sulfinyl or sulfonyl group all optical isomers thereof, and mixtures of the aforesaid optical isomers and acid addition salts thereof. Processes for the preparation of the new compounds as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds show valuable pharmacological properties, especially effects on the heat and circulation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3046465 | 1980-12-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES512915A0 ES512915A0 (en) | 1983-03-01 |
ES8304538A1 true ES8304538A1 (en) | 1983-03-01 |
Family
ID=6118763
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES507635A Granted ES507635A0 (en) | 1980-12-10 | 1981-12-02 | PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS. |
ES512913A Expired ES8304536A1 (en) | 1980-12-10 | 1982-06-08 | Chemical Compounds |
ES512914A Expired ES8304537A1 (en) | 1980-12-10 | 1982-06-08 | Chemical Compounds |
ES512915A Expired ES8304538A1 (en) | 1980-12-10 | 1982-06-08 | Chemical Compounds |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES507635A Granted ES507635A0 (en) | 1980-12-10 | 1981-12-02 | PROCEDURE FOR THE PREPARATION OF NEW PHENYLALCOHYLAMINS. |
ES512913A Expired ES8304536A1 (en) | 1980-12-10 | 1982-06-08 | Chemical Compounds |
ES512914A Expired ES8304537A1 (en) | 1980-12-10 | 1982-06-08 | Chemical Compounds |
Country Status (32)
Country | Link |
---|---|
JP (1) | JPS57122048A (en) |
KR (1) | KR870000183B1 (en) |
AR (1) | AR227802A1 (en) |
AT (1) | AT379378B (en) |
AU (1) | AU547655B2 (en) |
BE (1) | BE891416A (en) |
CA (1) | CA1202636A (en) |
CH (1) | CH651541A5 (en) |
CS (1) | CS229924B2 (en) |
DD (1) | DD202867A5 (en) |
DE (1) | DE3146623A1 (en) |
DK (1) | DK541981A (en) |
ES (4) | ES507635A0 (en) |
FI (1) | FI813934L (en) |
FR (1) | FR2498596B1 (en) |
GB (1) | GB2088873B (en) |
GR (1) | GR77323B (en) |
HU (1) | HU185676B (en) |
IE (1) | IE52007B1 (en) |
IL (1) | IL64498A (en) |
IT (1) | IT1172129B (en) |
LU (1) | LU83830A1 (en) |
NL (1) | NL8105170A (en) |
NO (1) | NO152649C (en) |
NZ (1) | NZ199215A (en) |
PH (1) | PH21599A (en) |
PL (1) | PL129385B1 (en) |
PT (1) | PT74112B (en) |
SE (1) | SE8107387L (en) |
SU (1) | SU1172449A3 (en) |
YU (1) | YU290381A (en) |
ZA (1) | ZA818529B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4720586A (en) * | 1983-12-06 | 1988-01-19 | Fisons, Plc | Substituted 3,4-dihydroxy-phenylethylamino compounds |
GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
GB8426191D0 (en) * | 1984-10-17 | 1984-11-21 | Glaxo Holdings Ltd | Chemical compounds |
US4943591A (en) * | 1984-10-17 | 1990-07-24 | Glaxo Group Limited | Dichloroaniline derivatives |
GB8603475D0 (en) * | 1986-02-12 | 1986-03-19 | Glaxo Group Ltd | Chemical compounds |
JPS63290852A (en) * | 1987-02-10 | 1988-11-28 | グラクソ、グループ、リミテッド | Compound |
GB8703007D0 (en) * | 1987-02-10 | 1987-03-18 | Glaxo Group Ltd | Chemical compounds |
US4906645A (en) * | 1988-09-12 | 1990-03-06 | Merck & Co., Inc. | Pyridyl aminoethanol compounds with growth promotion and an increase in feed efficiency |
DE4028398A1 (en) * | 1990-09-07 | 1992-03-12 | Thomae Gmbh Dr K | PHENYLETHANOLAMINES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE69227596T2 (en) * | 1991-10-04 | 1999-04-08 | Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo | ALKOXYPHENYLALKYLAMINE DERIVATIVE |
US8349898B2 (en) * | 2008-11-18 | 2013-01-08 | Wisconsin Alumni Research Foundation | Sigma-1 receptor ligands and methods of use |
GB201208775D0 (en) | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
US11999676B2 (en) | 2016-04-21 | 2024-06-04 | University Of Kentucky Research Foundation | Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse |
US10668030B2 (en) * | 2016-04-21 | 2020-06-02 | University Of Kentucky Research Foundation | Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse |
WO2023235153A1 (en) * | 2022-05-31 | 2023-12-07 | Corteva Agriscience Llc | Crystalline forms of picolinamide fungicide compound |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1618007A1 (en) * | 1967-05-09 | 1970-10-29 | Thomae Gmbh Dr K | Process for the production of new amino-monohalophenylaethanolamines |
DE2351281C3 (en) * | 1973-10-12 | 1981-07-30 | Dr. Karl Thomae Gmbh, 7950 Biberach | Aminophenylethanolamine derivatives, their production and use |
NL176168C (en) * | 1972-12-18 | 1985-03-01 | Thomae Gmbh Dr K | PROCEDURE FOR THE PREPARATION OR MANUFACTURE OF A PHARMACEUTICAL PREPARATION AND METHOD FOR THE PREPARATION OF USEFUL NEW SUBSTITUTED 1-(4-AMINOPHENYL)-2-AMINO-ETHANOL DERIVATIVES WHICH, EXCEPT AN ANALGETIC, UTERUS SPASMOLYTIC AND ANTI-SPASTIC ACTIVITY, HAVE RELATIVE STRIPES IN PARTICULAR HAVE A BETA2 MIMETIC AND/OR BETA1 BLOCKING ACTIVITY. |
GB1523974A (en) * | 1975-02-05 | 1978-09-06 | Yamanouchi Pharma Co Ltd | 4-substituted amino- -aminomethylbenzyl alcohol derivatives |
JPS51125232A (en) * | 1975-02-05 | 1976-11-01 | Yamanouchi Pharmaceut Co Ltd | Process for preparing 4-substituted amido-3,5-dihalogeno-alpha-substituted aminomethylbenzyl alcohols |
FI790459A (en) * | 1978-02-21 | 1979-08-22 | Sandoz Ag | NYA FENYLETYLAMINER FOERFARANDE FOER DERAS FRAMSTAELLNING OCH KOMPOSITIONER INNEHAOLLANDE DEM |
DK268579A (en) * | 1978-07-03 | 1980-01-04 | Lilly Co Eli | PROCEDURE FOR THE PREPARATION OF PHENETAMOLAMINES |
-
1981
- 1981-11-16 NL NL8105170A patent/NL8105170A/en not_active Application Discontinuation
- 1981-11-25 DE DE19813146623 patent/DE3146623A1/en not_active Withdrawn
- 1981-11-27 SU SU813358171A patent/SU1172449A3/en active
- 1981-11-30 AT AT0512981A patent/AT379378B/en not_active IP Right Cessation
- 1981-12-02 ES ES507635A patent/ES507635A0/en active Granted
- 1981-12-07 IT IT49853/81A patent/IT1172129B/en active
- 1981-12-07 DD DD81235491A patent/DD202867A5/en unknown
- 1981-12-07 GR GR66712A patent/GR77323B/el unknown
- 1981-12-07 CH CH7800/81A patent/CH651541A5/en not_active IP Right Cessation
- 1981-12-08 DK DK541981A patent/DK541981A/en not_active Application Discontinuation
- 1981-12-08 FI FI813934A patent/FI813934L/en not_active Application Discontinuation
- 1981-12-09 PL PL1981234155A patent/PL129385B1/en unknown
- 1981-12-09 AU AU78414/81A patent/AU547655B2/en not_active Ceased
- 1981-12-09 IL IL64498A patent/IL64498A/en unknown
- 1981-12-09 SE SE8107387A patent/SE8107387L/en not_active Application Discontinuation
- 1981-12-09 HU HU813708A patent/HU185676B/en unknown
- 1981-12-09 NO NO814194A patent/NO152649C/en unknown
- 1981-12-09 JP JP56198337A patent/JPS57122048A/en active Pending
- 1981-12-09 GB GB8137051A patent/GB2088873B/en not_active Expired
- 1981-12-09 NZ NZ199215A patent/NZ199215A/en unknown
- 1981-12-09 ZA ZA818529A patent/ZA818529B/en unknown
- 1981-12-09 BE BE0/206788A patent/BE891416A/en not_active IP Right Cessation
- 1981-12-09 CA CA000391831A patent/CA1202636A/en not_active Expired
- 1981-12-09 IE IE2888/81A patent/IE52007B1/en unknown
- 1981-12-10 FR FR8123106A patent/FR2498596B1/en not_active Expired
- 1981-12-10 YU YU02903/81A patent/YU290381A/en unknown
- 1981-12-10 PH PH26726A patent/PH21599A/en unknown
- 1981-12-10 LU LU83830A patent/LU83830A1/en unknown
- 1981-12-10 PT PT74112A patent/PT74112B/en unknown
- 1981-12-10 KR KR1019810004912A patent/KR870000183B1/en active IP Right Grant
- 1981-12-10 AR AR287754A patent/AR227802A1/en active
- 1981-12-10 CS CS819178A patent/CS229924B2/en unknown
-
1982
- 1982-06-08 ES ES512913A patent/ES8304536A1/en not_active Expired
- 1982-06-08 ES ES512914A patent/ES8304537A1/en not_active Expired
- 1982-06-08 ES ES512915A patent/ES8304538A1/en not_active Expired
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