Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Synthelabo SA
Original Assignee
Synthelabo SA
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Filing date
Publication date
Application filed by Synthelabo SAfiledCriticalSynthelabo SA
Priority to ES508080ApriorityCriticalpatent/ES8303410A1/es
Publication of ES508080A0publicationCriticalpatent/ES508080A0/es
Publication of ES8303410A1publicationCriticalpatent/ES8303410A1/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE INDOLOQUINOLIZINA, EN FORMA DE RECEMATOS O ISOMEROS OPTICOS Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, B Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE NITROXACION DE LA HEXAHIDRO-2,3,4,6,7,12-INDOLO 2,3-A QUINOLIZINA; SEGUIDA DEL TRATAMIENTO DEL DERIVADO NITROSO CON ACIDO FUERTE; Y REDUCCION DEL DERIVADO HIDROXIMINO INSATURADO, ASI OBTENIDO, CON BOROHIDRURO DE SODIO EN DISOLUCION ALCOHOLICA Y POSTERIOR REDUCCION CON HIDRURO DE LITIO Y ALUMINIO O HIDRURO DE BIS(2-METOXIETOXI)-ALUMINIO-SODIO EN DISOLUCION ETEREA; O POR HIDROGENACION CATALITICA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE AFECCIONES VASCULARES.
ES508080A1981-12-171981-12-17"un procedimiento de preparacion de derivados de indolo quinolizina".
ExpiredES8303410A1
(es)