ES8300744A1 - "un procedimiento para preparar derivados de bencimidazol". - Google Patents

"un procedimiento para preparar derivados de bencimidazol".

Info

Publication number
ES8300744A1
ES8300744A1 ES508374A ES508374A ES8300744A1 ES 8300744 A1 ES8300744 A1 ES 8300744A1 ES 508374 A ES508374 A ES 508374A ES 508374 A ES508374 A ES 508374A ES 8300744 A1 ES8300744 A1 ES 8300744A1
Authority
ES
Spain
Prior art keywords
benzimidazole
thiol
reacting
produce
pyridinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508374A
Other languages
English (en)
Other versions
ES508374A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES508374A0 publication Critical patent/ES508374A0/es
Publication of ES8300744A1 publication Critical patent/ES8300744A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENCIMIDAZOL Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE Z ES OXIGENO O AZUFRE; Y ES UN ALQUILENO C <003> O UN ENLACE DIRECTO; R ES HIDROGENO O ALQUILO INFERIOR; Y P<029> ES 4- O 3-PIRIDINILO O 1-OXIDO DE PIRIDINILO. CONSISTE EN LA REACCION DE UNA 4-(P<029>-Y)-1,2-BENCENDIAMINA CORRESPONDIENTE CON UREA O CARBONILDIIMIDAZOL, CUANDO Z-R ES OH; CON TIOUREA, UN XANTATO DE ALQUILO INFERIOR ALCALINOMETALICO O TIOCARBONILDIIMIDAZOL, CUANDO Z-R ES SH; O CON TETRA(ALCOXI INFERIOR)METANO, CUANDO Z ES OXIGENO Y R ES ALQUILO INFERIOR. TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
ES508374A 1980-12-29 1981-12-28 "un procedimiento para preparar derivados de bencimidazol". Expired ES8300744A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/220,977 US4335132A (en) 1980-12-29 1980-12-29 5-(Py-Y)-1H-benzimidazol-2-ols and 5-(Py-Y-)-1H-benzimidazole-2-thiols

Publications (2)

Publication Number Publication Date
ES508374A0 ES508374A0 (es) 1982-11-01
ES8300744A1 true ES8300744A1 (es) 1982-11-01

Family

ID=22825829

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508374A Expired ES8300744A1 (es) 1980-12-29 1981-12-28 "un procedimiento para preparar derivados de bencimidazol".

Country Status (13)

Country Link
US (1) US4335132A (es)
EP (1) EP0055453A3 (es)
JP (1) JPS57134481A (es)
KR (1) KR830007627A (es)
AU (1) AU543328B2 (es)
CA (1) CA1180714A (es)
DK (1) DK575081A (es)
ES (1) ES8300744A1 (es)
FI (1) FI814168L (es)
IL (1) IL64674A (es)
NO (1) NO814348L (es)
PT (1) PT74213B (es)
ZA (1) ZA818897B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4430502A (en) * 1982-08-13 1984-02-07 The Upjohn Company Pyridinyl substituted benzimidazoles and quinoxalines
LU85298A1 (fr) * 1984-04-11 1985-11-27 Wurth Paul Sa Dispositif d'introduction de quantites dosees de matieres pulverulentes dans un fluide de propulsion pneumatique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE659364A (es) * 1964-02-05
US3914310A (en) * 1965-08-06 1975-10-21 Ciba Geigy Corp Phenoxy-substituted ortho-nitroanilines and ortho-phenylenediamines
DE2202204C2 (de) * 1972-01-18 1983-06-01 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von 2-Mercaptobenzimidazol
FR2213305B1 (es) * 1973-01-08 1978-06-23 Ciba Geigy Ag
US3907822A (en) * 1973-06-11 1975-09-23 Squibb & Sons Inc Anti-inflammatory (2-benzimidazoylthio)alkylamidoximes
US4026936A (en) * 1975-08-07 1977-05-31 Hoffmann-La Roche Inc. Anthelmintic pyridine and thiazole substituted benzimidazole carbamates

Also Published As

Publication number Publication date
IL64674A (en) 1984-11-30
AU7884181A (en) 1982-07-08
FI814168L (fi) 1982-06-30
ZA818897B (en) 1982-11-24
NO814348L (no) 1982-06-30
PT74213B (en) 1983-05-30
JPS57134481A (en) 1982-08-19
EP0055453A2 (en) 1982-07-07
ES508374A0 (es) 1982-11-01
KR830007627A (ko) 1983-11-04
EP0055453A3 (en) 1982-09-01
DK575081A (da) 1982-06-30
AU543328B2 (en) 1985-04-18
US4335132A (en) 1982-06-15
PT74213A (en) 1982-01-01
CA1180714A (en) 1985-01-08
IL64674A0 (en) 1982-03-31

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