ES8300704A1 - Un procedimiento para la preparacion del n-oxido del 4 hetoxi-n-(2-(-(imetil-2-piperidil) etil) fenil)benzamida. - Google Patents

Un procedimiento para la preparacion del n-oxido del 4 hetoxi-n-(2-(-(imetil-2-piperidil) etil) fenil)benzamida.

Info

Publication number
ES8300704A1
ES8300704A1 ES503194A ES503194A ES8300704A1 ES 8300704 A1 ES8300704 A1 ES 8300704A1 ES 503194 A ES503194 A ES 503194A ES 503194 A ES503194 A ES 503194A ES 8300704 A1 ES8300704 A1 ES 8300704A1
Authority
ES
Spain
Prior art keywords
oxide
encainide
piperidyl
benzamide
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503194A
Other languages
English (en)
Other versions
ES503194A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES503194A0 publication Critical patent/ES503194A0/es
Publication of ES8300704A1 publication Critical patent/ES8300704A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL N-OXIDO DE 4-METOXI-N<014>2 <014>2-(1-METIL-2-PIPERIDIL)ETIL<015>FENIL<015>BENZAMIDA. CONSISTE EN LA REACCION DE OXIDACION DE LA 4-METOXI-N-<014>2-<014> 2-(1-METIL-2-PIPERIDIL)ETIL<015>FENIL<015>BENZAMIDA. LA REACCION SE LLEVA A CABO CON PEROXIDO DE HIDROGENO EN MEDIO ACUOSO A LA TEMPERATURA AMBIENTE. EL PRODUCTO OBTENIDO SE SEPARO Y PURIFICO SIGUIENDO METODOS CONVENCIONALES. >ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTIARRITMICO.
ES503194A 1980-06-19 1981-06-17 Un procedimiento para la preparacion del n-oxido del 4 hetoxi-n-(2-(-(imetil-2-piperidil) etil) fenil)benzamida. Expired ES8300704A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/160,900 US4306069A (en) 1980-06-19 1980-06-19 Encainide N-oxide

Publications (2)

Publication Number Publication Date
ES503194A0 ES503194A0 (es) 1982-11-01
ES8300704A1 true ES8300704A1 (es) 1982-11-01

Family

ID=22578951

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503194A Expired ES8300704A1 (es) 1980-06-19 1981-06-17 Un procedimiento para la preparacion del n-oxido del 4 hetoxi-n-(2-(-(imetil-2-piperidil) etil) fenil)benzamida.

Country Status (25)

Country Link
US (1) US4306069A (es)
JP (1) JPS5756459A (es)
AT (1) AT376422B (es)
AU (1) AU525564B2 (es)
BE (1) BE889309A (es)
CA (1) CA1149388A (es)
CH (1) CH647761A5 (es)
CY (1) CY1363A (es)
DE (1) DE3123942C2 (es)
DK (1) DK152671C (es)
ES (1) ES8300704A1 (es)
FI (1) FI65060C (es)
FR (1) FR2485007B1 (es)
GB (1) GB2078729B (es)
GR (1) GR74526B (es)
HK (1) HK49687A (es)
IE (1) IE51307B1 (es)
IT (1) IT1143202B (es)
KE (1) KE3702A (es)
LU (1) LU83440A1 (es)
NL (1) NL8102899A (es)
SE (1) SE435058B (es)
SG (1) SG22287G (es)
YU (1) YU42239B (es)
ZA (1) ZA813802B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824853A (en) * 1985-10-11 1989-04-25 Janssen Pharmaceutica N.V. α,α-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides and method of treating diarrhea
CN1200122A (zh) * 1995-10-25 1998-11-25 詹森药业有限公司 鲁贝洛唑n－氧化物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785168A (en) * 1955-08-16 1957-03-12 Upjohn Co Ethyl 1-methyl-4-phenylisonipecotate nu-oxides
US3931195A (en) * 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines

Also Published As

Publication number Publication date
ZA813802B (en) 1982-06-30
YU42239B (en) 1988-06-30
FR2485007B1 (fr) 1985-07-26
JPS5756459A (en) 1982-04-05
GB2078729B (en) 1984-07-11
US4306069A (en) 1981-12-15
AT376422B (de) 1984-11-26
CH647761A5 (de) 1985-02-15
DK152671C (da) 1988-08-22
DK266481A (da) 1981-12-20
LU83440A1 (fr) 1982-04-14
CY1363A (en) 1987-08-07
DE3123942C2 (de) 1986-08-28
HK49687A (en) 1987-07-03
ES503194A0 (es) 1982-11-01
IE811354L (en) 1981-12-19
CA1149388A (en) 1983-07-05
FI65060B (fi) 1983-11-30
IE51307B1 (en) 1986-11-26
FI65060C (fi) 1984-03-12
JPS6124390B2 (es) 1986-06-10
NL8102899A (nl) 1982-01-18
DE3123942A1 (de) 1982-07-22
KE3702A (en) 1987-03-27
IT8148683A0 (it) 1981-06-15
AU525564B2 (en) 1982-11-11
SE8103822L (sv) 1981-12-20
IT1143202B (it) 1986-10-22
FI811884L (fi) 1981-12-20
DK152671B (da) 1988-04-11
ATA272681A (de) 1984-04-15
YU132281A (en) 1984-02-29
FR2485007A1 (fr) 1981-12-24
BE889309A (fr) 1981-12-21
SE435058B (sv) 1984-09-03
GR74526B (es) 1984-06-29
GB2078729A (en) 1982-01-13
SG22287G (en) 1987-07-03
AU7088081A (en) 1981-12-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303