ES8300316A1 - Procedure for obtaining a derivative of 4-hydroxy-cycle-hexilamine. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for obtaining a derivative of 4-hydroxy-cycle-hexilamine. (Machine-translation by Google Translate, not legally binding)
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Ferrer Internacional SA
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Ferrer Internacional SA
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Priority to ES508642ApriorityCriticalpatent/ES508642A0/en
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Publication of ES508642A0publicationCriticalpatent/ES508642A0/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts
(AREA)
Abstract
Procedure for the obtaining of a derivative of 4-hydroxiciclohexilamine, formula (I) and its chlorhydrate. Consists of the reaction of a compound of formula (II) with light excess of lithium and aluminum hydride, in the presence of a catalytic amount of aluminum tricloride, in a type ester solvent, a reflux; followed by addition of ethyl acetate, filtration, washing of the precipitate with the same eter, evaporation of the solvent at reduced pressure, treatment to reflux with a equimolecular amount of 4-hydroxiciclohexanone in an alcohol c <003> r; following reaction with borohidride in excess, addition of water, dissolution of precipitate in a halogenated solvent, addition of hydrogen chloride, filtration and drying. These compounds have pharmacological applications as mucolitics. (Machine-translation by Google Translate, not legally binding)
ES508642A1981-12-171981-12-17
PROCEDURE FOR OBTAINING A DERIVATIVE OF 4-HYDROXY-CYCLE-HEXYLAMINE.
GrantedES508642A0
(en)
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