ES445254A1 - A procedure for the preparation of 3-substitute methyl-2 or 3-cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of 3-substitute methyl-2 or 3-cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
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Fujisawa Pharmaceutical Co Ltd
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Fujisawa Pharmaceutical Co Ltd
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Publication of ES445254A1publicationCriticalpatent/ES445254A1/en
A procedure for the preparation of 3-substituted methyl-2 or 3-cephem-4-carboxylic acids of general formula: **(See formula)** where A is (see formula), R is hydrogen or acyl and R2 is a residue of a nucleophile, or a salt or ester thereof, the procedure of which is to react a compound of the general formula: **(See formula)** where A and R1 are each as defined above and X is a group convertible to a residue of a nucleophile, or a salt or ester thereof, with a nucleophile in water or in an organic solvent mixed with water, in the presence of a quaternary ammonium salt or a phosphonium salt and, if necessary, reduce the resulting compound when A in said compound is to obtain the group -S- and, if necessary, subject the resulting compound to an elimination reaction when Said resulting compound is a salt or ester to obtain the carboxy group. (Machine-translation by Google Translate, not legally binding)
ES445254A1973-01-171976-02-17A procedure for the preparation of 3-substitute methyl-2 or 3-cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ExpiredES445254A1
(en)