ES8205417A1 - Procedimiento para preparar composiciones de corticoesteroi-des-esteres de l-arginina acuosolubles - Google Patents

Procedimiento para preparar composiciones de corticoesteroi-des-esteres de l-arginina acuosolubles

Info

Publication number
ES8205417A1
ES8205417A1 ES497508A ES497508A ES8205417A1 ES 8205417 A1 ES8205417 A1 ES 8205417A1 ES 497508 A ES497508 A ES 497508A ES 497508 A ES497508 A ES 497508A ES 8205417 A1 ES8205417 A1 ES 8205417A1
Authority
ES
Spain
Prior art keywords
corticosteroid
pharmaceutical compositions
compositions containing
substance
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497508A
Other languages
English (en)
Other versions
ES497508A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Publication of ES8205417A1 publication Critical patent/ES8205417A1/es
Publication of ES497508A0 publication Critical patent/ES497508A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

PR OCEDIMIENTO PARA LA OBTENCION DE COMPOSICIONES DE CORTICOESTEROIDES-ESTERES E L-ARGININA ACUOSOLUBLES, QUE TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD CONTRA EL "SHOCK" ENDOTOXINICO O ANALFAICO. CONSISTE EN LA DISOLUCION EN AGUA O EN DISOLUCION ACUOSA TAMPONADA A PH ENTRE 5,5 Y 8,5, DE CANTIDADES EQUIMOLECULARES DE UN ESTER DE L-ARGININA DE FORMULA (I), ENLA QUE R ES UN RADICAL ALQUILO INFERIOR Y X ES UN ANION ORGANICO O INORGANICO FISIOLOGICAMENTE COMPATIBLE CON UN CORTICOESTEROIDE O UNA DE SUS SALES, AL COMO EL 6-ALFA-METILPREDNISOLONA-21-SUCCINATO SODICO.
ES497508A 1979-12-28 1980-12-05 Procedimiento para preparar composiciones de corticoesteroi-des-esteres de l-arginina acuosolubles Granted ES497508A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT28417/79A IT1127322B (it) 1979-12-28 1979-12-28 Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici

Publications (2)

Publication Number Publication Date
ES8205417A1 true ES8205417A1 (es) 1982-06-16
ES497508A0 ES497508A0 (es) 1982-06-16

Family

ID=11223560

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497508A Granted ES497508A0 (es) 1979-12-28 1980-12-05 Procedimiento para preparar composiciones de corticoesteroi-des-esteres de l-arginina acuosolubles

Country Status (24)

Country Link
US (1) US4282217A (es)
JP (1) JPS56103113A (es)
AR (1) AR224288A1 (es)
AU (1) AU524820B2 (es)
BE (1) BE886758A (es)
BR (1) BR8008493A (es)
CA (1) CA1161362A (es)
DE (1) DE3027039C2 (es)
DK (1) DK524080A (es)
ES (1) ES497508A0 (es)
FI (1) FI803767L (es)
FR (1) FR2472388A1 (es)
GB (1) GB2066072B (es)
GR (1) GR72504B (es)
IE (1) IE50549B1 (es)
IN (1) IN152354B (es)
IT (1) IT1127322B (es)
LU (1) LU83029A1 (es)
NL (1) NL182775C (es)
NO (1) NO803916L (es)
PH (1) PH17384A (es)
PT (1) PT72274B (es)
SE (1) SE8009103L (es)
ZA (1) ZA807516B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1201511B (it) * 1985-12-23 1989-02-02 Italfarmaco Spa Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
JPS6310084U (es) * 1986-07-07 1988-01-22
US5312835A (en) * 1989-09-13 1994-05-17 Board Of Regents, The University Of Texas System Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5770623A (en) * 1989-09-13 1998-06-23 Board Of Regents, The University Of Texas System Argine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5158883A (en) * 1989-09-13 1992-10-27 Cornell Research Foundation, Inc. Method of using aminoarginine to block nitric oxide formation in vitro
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
US5196195A (en) * 1990-03-27 1993-03-23 Cornell Research Foundation, Inc. Use of arginase to control nitric oxide formation
US5395612A (en) * 1990-03-27 1995-03-07 Cornell Research Foundation, Inc. Method for treating systemic hypotension caused by sepsis or cytokine using arginase in combination with an α1 adrenergic agonist
SE468881B (sv) * 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
US5273875A (en) * 1991-03-22 1993-12-28 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
US5374651A (en) * 1991-09-27 1994-12-20 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
JP2534423B2 (ja) 1991-12-26 1996-09-18 コーネル・リサーチ・ファンデーション・インコーポレイテッド 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤
US5281627A (en) * 1992-05-28 1994-01-25 Cornell Research Foundation, Inc. Substituted arginines and substituted homoarginines and use thereof
US5585402A (en) * 1992-12-23 1996-12-17 Glaxo Wellcome Inc. Nitric oxide synthase inhibitors
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
KR100472303B1 (ko) * 2002-05-21 2005-03-08 김영미 결장표적성 프로드럭으로서의 코티코스테로이드21-설페이트 소듐 유도체
US8439922B1 (en) 2008-02-06 2013-05-14 NiVasive, Inc. Systems and methods for holding and implanting bone anchors
US9198698B1 (en) 2011-02-10 2015-12-01 Nuvasive, Inc. Minimally invasive spinal fixation system and related methods
US9486256B1 (en) 2013-03-15 2016-11-08 Nuvasive, Inc. Rod reduction assemblies and related methods
US9974577B1 (en) 2015-05-21 2018-05-22 Nuvasive, Inc. Methods and instruments for performing leveraged reduction during single position spine surgery
US10398481B2 (en) 2016-10-03 2019-09-03 Nuvasive, Inc. Spinal fixation system
US11051861B2 (en) 2018-06-13 2021-07-06 Nuvasive, Inc. Rod reduction assemblies and related methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320125A (en) * 1964-04-28 1967-05-16 Merck & Co Inc Inhalation aerosol composition
CA939265A (en) * 1967-11-18 1974-01-01 Yoshitaka Ikezuki Injectable compositions for alleviating the pain incurred from administrations of injections
US3639585A (en) * 1968-03-29 1972-02-01 Res Inst Medicine Chem Method of preventing corticosteroid-induced adverse effects on bon and compositions useful in said method
JPS5035061A (es) * 1973-07-28 1975-04-03

Also Published As

Publication number Publication date
BE886758A (nl) 1981-04-16
NL182775C (nl) 1988-05-16
FI803767L (fi) 1981-06-29
PT72274B (en) 1981-11-05
FR2472388A1 (fr) 1981-07-03
AU524820B2 (en) 1982-10-07
DK524080A (da) 1981-06-29
CA1161362A (en) 1984-01-31
GB2066072A (en) 1981-07-08
US4282217A (en) 1981-08-04
IT7928417A0 (it) 1979-12-28
NO803916L (no) 1981-06-29
FR2472388B1 (es) 1983-04-01
JPS56103113A (en) 1981-08-18
GR72504B (es) 1983-11-15
DE3027039C2 (de) 1984-05-17
IN152354B (es) 1983-12-24
AU6502980A (en) 1981-07-02
ES497508A0 (es) 1982-06-16
IE50549B1 (en) 1986-05-14
AR224288A1 (es) 1981-11-13
BR8008493A (pt) 1981-07-14
IE802605L (en) 1981-06-28
ZA807516B (en) 1981-11-25
DE3027039A1 (de) 1981-07-02
LU83029A1 (de) 1981-03-27
NL182775B (nl) 1987-12-16
GB2066072B (en) 1984-02-01
JPS6144844B2 (es) 1986-10-04
IT1127322B (it) 1986-05-21
NL8006707A (nl) 1981-07-16
SE8009103L (sv) 1981-06-29
PH17384A (en) 1984-08-06
PT72274A (en) 1981-01-01

Similar Documents

Publication Publication Date Title
ES8205417A1 (es) Procedimiento para preparar composiciones de corticoesteroi-des-esteres de l-arginina acuosolubles
IL59628A (en) 4-amino-3-quinolinecarboxylic acids and salts and esters thereof and pharmaceutical compositions containing them
DE3065315D1 (en) A preparation containing nitroglycerine and optionally other medicaments and preparation thereof
NZ189253A (en) Amine derivatives and pharmaceutical compositions
DE3068803D1 (en) The use of 2-phenyltetralin derivatives, or heterocyclic analogues, in medicine and pharmaceutical compositions containing them
GB1520584A (en) 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions
IT8149623A0 (it) Derivati encefalinici dotati di attivita' analgesica e composizioni farmaceutiche che li contengono
DE3068530D1 (en) Pharmaceutical composition containing paracetamol, treatment pack comprising said composition and method of reducing liver toxicity effect of paracetamol compositions
JPS5242832A (en) Aniline derivative* preparation thereof and combating agent* against microorganisms* containing said coumpound as active component
IL42369A0 (en) Synergistic fungicidal compositions containing a certain benzimidazole derivative and an n-substituted phthalimide
EG13676A (en) New benzodioxole derivatives;processes for their preparation and their use as synergistic agents in insecticidal and acaricidal compositions
ES8205394A1 (es) Procedimiento para preparar esteres de l-arginina en solu- cion acuosa
IT8048308A0 (it) Derivati benzotiazolici procedimento per prepararli e composizioni farmaceutiche che li contengono
AU4607779A (en) Dichlorobenzodioxole derivatives and their use as synergistic agents in arthropodicidal compositions
IL60040A0 (en) Imidazole derivatives and pharmaceutical compositions containing them
GB2054594B (en) New nitroalkanol derivatives and their preparation and formulation as plant protecting agents
IL50584A0 (en) Herbicidal synergistic compositions containing certain triazine derivatives and certain carboxylic acids
IL49805A0 (en) Synergistic compositions containing a certain substituted urea and a certain diphenyl ether derivative for the selective combating of weeds in cereals
JPS54151925A (en) Nn*1**methoxycarbonylethyl**nn*n**n** disubstituted hydrazinoacetyl**aniline derivative*its manufacture and fungicidal composition containing it as active component
IL59059A0 (en) Method and synergistic compositions for combating insects
IL53473A0 (en) Synergistic insecticidal and acaricidal compositions comprising certain benzodioxole derivatives and certain other active compounds
IL62826A (en) Fluoromethylated pyrosine methyl ester,its salts and pharmaceutical compositions comprising them
JPS5265231A (en) Formamidine derivative* preparation thereof and combating agent* against harmful organisms* containing same
NZ184161A (en) Pharmaceutical and veterinary compositions with certain methylamines as active ingredients
JPS5572116A (en) Anti-tumor agent