ES8203889A1 - Procedimiento de preparacion de nuevos derivados de acido 4-hidroxi-3-quinolein-carboxilico,sustituidos en posicion 2 - Google Patents

Procedimiento de preparacion de nuevos derivados de acido 4-hidroxi-3-quinolein-carboxilico,sustituidos en posicion 2

Info

Publication number
ES8203889A1
ES8203889A1 ES502264A ES502264A ES8203889A1 ES 8203889 A1 ES8203889 A1 ES 8203889A1 ES 502264 A ES502264 A ES 502264A ES 502264 A ES502264 A ES 502264A ES 8203889 A1 ES8203889 A1 ES 8203889A1
Authority
ES
Spain
Prior art keywords
carbon atoms
group
alkyl
hydrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502264A
Other languages
English (en)
Spanish (es)
Other versions
ES502264A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES502264A0 publication Critical patent/ES502264A0/es
Publication of ES8203889A1 publication Critical patent/ES8203889A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Control Of Steam Boilers And Waste-Gas Boilers (AREA)
  • Measurement Of Radiation (AREA)
ES502264A 1980-05-19 1981-05-18 Procedimiento de preparacion de nuevos derivados de acido 4-hidroxi-3-quinolein-carboxilico,sustituidos en posicion 2 Expired ES8203889A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8011100A FR2482596A1 (fr) 1980-05-19 1980-05-19 Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament

Publications (2)

Publication Number Publication Date
ES502264A0 ES502264A0 (es) 1982-04-01
ES8203889A1 true ES8203889A1 (es) 1982-04-01

Family

ID=9242091

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502264A Expired ES8203889A1 (es) 1980-05-19 1981-05-18 Procedimiento de preparacion de nuevos derivados de acido 4-hidroxi-3-quinolein-carboxilico,sustituidos en posicion 2

Country Status (17)

Country Link
US (2) US4397856A (enExample)
EP (2) EP0040573B1 (enExample)
JP (1) JPS5731665A (enExample)
AT (2) ATE8783T1 (enExample)
AU (1) AU543580B2 (enExample)
CA (1) CA1184558A (enExample)
DE (2) DE3177205D1 (enExample)
DK (1) DK152212C (enExample)
ES (1) ES8203889A1 (enExample)
FI (1) FI77030C (enExample)
FR (1) FR2482596A1 (enExample)
HU (1) HU184853B (enExample)
IE (1) IE56506B1 (enExample)
OA (1) OA06814A (enExample)
PH (2) PH17403A (enExample)
PT (1) PT73050B (enExample)
ZA (1) ZA813293B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
HU190796B (en) * 1981-06-12 1986-11-28 Roussel Uclaf,Fr Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2530633A1 (fr) * 1982-06-03 1984-01-27 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant
FR2532314B1 (fr) * 1982-08-25 1985-07-19 Roussel Uclaf Nouveau procede de preparation de derives de l'acide 3-quinoleine carboxylique, nouveaux derives halogenes de l'acide 3-quinoleine carboxylique, leur application comme medicaments, les compositions pharmaceutiques les renfermant et les intermediaires nouveaux obtenus
FR2553769B1 (fr) * 1983-10-20 1986-03-14 Roussel Uclaf Nouveau procede de preparation de derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2
US4731480A (en) * 1985-07-29 1988-03-15 Ortho Pharmaceutical Corporation Process for preparing 2-acyl-3,4-dialkoxyanilines
US4844732A (en) * 1985-10-24 1989-07-04 Daicel Chemical Industries Ltd. Pyridine-3-carboxamide derivatives
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
DE4410539A1 (de) * 1994-03-26 1995-09-28 Sandoz Ag Verwendung von 4 H-3,1-Benzoxazin-4-on-Verbindungen zur Verbesserung der Lichtechtheit von Textilmaterialien
EP1042295B1 (en) * 1997-12-22 2005-09-07 Pharmacia & Upjohn Company LLC 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
EP1820504A1 (en) * 2004-11-15 2007-08-22 Taisho Pharmaceutical Co., Ltd Imine compound
KR20130100300A (ko) 2010-08-27 2013-09-10 그뤼넨탈 게엠베하 Ｋｃｎｑ２／３ 조절제로서의 치환된 ２-옥시-퀴놀린-３-카복스아미드
MX2013000748A (es) 2010-08-27 2013-03-05 Gruenenthal Gmbh 2-amino-quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3.
PL2609086T3 (pl) 2010-08-27 2015-07-31 Gruenenthal Gmbh Podstawione 2-okso- i 2-tiookso-dihydrochinolino-3-karboksyamidy jako modulatory KCNQ2/3
CA2804824A1 (en) 2010-08-27 2012-03-01 Gruenenthal Gmbh Substituted quinoline-3-carboxamides as kcnq2/3 modulators
BR112013005056A2 (pt) 2010-09-01 2016-05-31 Gruenenthal Gmbh 1-oxo-di-hidroisoquinolina-3-carboxamidas substituídas como moduladores kcnq2/3

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB874980A (en) * 1958-12-17 1961-08-16 Imp Cmemical Ind Ltd Quinoline derivatives
US3357977A (en) * 1964-01-06 1967-12-12 Minnesota Mining & Mfg Novel anthranyl intermediates
HU173974B (hu) * 1971-08-30 1979-10-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija proizvodnykh 3,1-benzoksazin-4-ona
GB1410178A (en) 1972-03-13 1975-10-15 Pfizer Substituted quinazolinones as herbicides
CA1034124A (en) * 1973-05-11 1978-07-04 Ciba-Geigy Ag Process for the manufacture of new quinolines
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
US3989698A (en) * 1975-02-20 1976-11-02 The Sherwin-Williams Company Process for preparing benzoxazines
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
US4229831A (en) * 1978-12-22 1980-10-21 Burroughs Corporation Drift compensated fiber optic-receiver

Also Published As

Publication number Publication date
ZA813293B (en) 1982-05-26
JPS6340430B2 (enExample) 1988-08-11
PT73050B (fr) 1983-02-08
IE56506B1 (en) 1991-08-28
OA06814A (fr) 1982-12-31
ATE8783T1 (de) 1984-08-15
AU543580B2 (en) 1985-04-26
CA1184558A (fr) 1985-03-26
DE3165209D1 (en) 1984-09-06
JPS5731665A (en) 1982-02-20
FI77030C (fi) 1989-01-10
EP0040573A2 (fr) 1981-11-25
DK152212B (da) 1988-02-08
ES502264A0 (es) 1982-04-01
AU7068981A (en) 1981-11-26
EP0143123A2 (fr) 1985-06-05
FR2482596B1 (enExample) 1983-04-29
PT73050A (fr) 1981-06-01
US4397856A (en) 1983-08-09
FI77030B (fi) 1988-09-30
DK152212C (da) 1988-08-08
PH17403A (en) 1984-08-08
FI811529L (fi) 1981-11-20
IE811112L (en) 1981-11-19
US4518775A (en) 1985-05-21
ATE54913T1 (de) 1990-08-15
EP0143123A3 (en) 1986-09-03
EP0040573A3 (en) 1982-01-13
PH21164A (en) 1987-08-05
EP0143123B1 (fr) 1990-07-25
DE3177205D1 (de) 1990-08-30
EP0040573B1 (fr) 1984-08-01
HU184853B (en) 1984-10-29
DK217281A (da) 1981-11-20
FR2482596A1 (fr) 1981-11-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110