ES8202808A1 - Un procedimiento para la preparacion de derivados de benzofurano. - Google Patents
Un procedimiento para la preparacion de derivados de benzofurano.Info
- Publication number
- ES8202808A1 ES8202808A1 ES496880A ES496880A ES8202808A1 ES 8202808 A1 ES8202808 A1 ES 8202808A1 ES 496880 A ES496880 A ES 496880A ES 496880 A ES496880 A ES 496880A ES 8202808 A1 ES8202808 A1 ES 8202808A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- ethanol amines
- hydrogen
- secondary ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002169 ethanolamines Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
- 239000000883 anti-obesity agent Substances 0.000 abstract 1
- 229940125710 antiobesity agent Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL BENZOFURANO Y DE SUS ESTERES, AMIDAS O SALES, FISOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A1 Y A2 PUEDEN SER HIDROGENO O METILO; R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES; Y N VALE DE 1 A 3. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R, A1, A2 Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y W PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE POLAR TAL COMO UN ALCANOL INFERIOR Y SI ES NECESARIO, EL PRODUCTO OBTENIDO SE REDUCE CON UN HIDRURO, TAL COMO HIDRURO SODICO O POR HIDROGENACION CATALITICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7939536 | 1979-11-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8202808A1 true ES8202808A1 (es) | 1982-02-16 |
| ES496880A0 ES496880A0 (es) | 1982-02-16 |
Family
ID=10509209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES496880A Granted ES496880A0 (es) | 1979-11-15 | 1980-11-14 | Un procedimiento para la preparacion de derivados de benzofurano. |
| ES507410A Granted ES507410A0 (es) | 1979-11-15 | 1981-11-24 | Un procedimiento para la preparacion de derivados del benzo-furano. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES507410A Granted ES507410A0 (es) | 1979-11-15 | 1981-11-24 | Un procedimiento para la preparacion de derivados del benzo-furano. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4341793A (es) |
| EP (1) | EP0029320B1 (es) |
| JP (1) | JPS5683484A (es) |
| AT (1) | ATE14222T1 (es) |
| AU (1) | AU540343B2 (es) |
| CA (1) | CA1161053A (es) |
| DE (1) | DE3070865D1 (es) |
| DK (1) | DK489180A (es) |
| ES (2) | ES496880A0 (es) |
| IE (1) | IE50475B1 (es) |
| IL (1) | IL61496A0 (es) |
| NZ (1) | NZ195551A (es) |
| ZA (1) | ZA807078B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0070133B1 (en) * | 1981-07-11 | 1986-05-14 | Beecham Group Plc | Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application |
| CA1219865A (en) * | 1982-05-14 | 1987-03-31 | Leo Alig | Aziridine phenethanolamine derivatives |
| CA1258454A (en) * | 1982-08-10 | 1989-08-15 | Leo Alig | Phenethanolamines |
| EP0139921B1 (en) * | 1983-08-17 | 1987-03-25 | Beecham Group Plc | 2-phenylethylamine derivatives |
| US5151439A (en) * | 1990-05-04 | 1992-09-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
| US5106867A (en) * | 1990-05-04 | 1992-04-21 | American Cyanamid Company | Method of increasing lean meat in edible animals |
| US5061727A (en) * | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
| US5245053A (en) * | 1990-05-04 | 1993-09-14 | American Cyanamid Company | Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxoles |
| AT395849B (de) * | 1991-04-04 | 1993-03-25 | Noe Christian R | Pharmakologisch aktive in position 3 substituierte alpha-aminomethyl-2benzofuranmethanole |
| WO1994029290A1 (en) * | 1993-06-14 | 1994-12-22 | Pfizer Inc. | Secondary amines as antidiabetic and antiobesity agents |
| US5578638A (en) * | 1993-11-05 | 1996-11-26 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists |
| US5563171A (en) * | 1993-11-05 | 1996-10-08 | American Cyanamid Company | Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists |
| US5627200A (en) * | 1994-09-26 | 1997-05-06 | Pfizer Inc | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia |
| EP0801060A1 (en) * | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclic Beta-3 Adrenergenic Agonists |
| FR2758460B1 (fr) * | 1997-01-21 | 1999-12-31 | Sanofi Sa | Utilisation des agonistes des recepteurs beta-3 adrenergiques pour la preparation de medicaments cicatrisants |
| JP4917018B2 (ja) * | 2004-05-03 | 2012-04-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 選択的アンドローゲン受容体モジュレーター（ｓａｒｍｓ）としての新規インドール化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE663926A (es) * | 1964-05-20 | |||
| DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
| IL57671A (en) * | 1978-07-03 | 1982-11-30 | Lilly Co Eli | Phenethanolamines,process for their preparation and pharmaceutical and animal feed compositions containing the same |
-
1980
- 1980-11-05 EP EP80303931A patent/EP0029320B1/en not_active Expired
- 1980-11-05 AT AT80303931T patent/ATE14222T1/de not_active IP Right Cessation
- 1980-11-05 DE DE8080303931T patent/DE3070865D1/de not_active Expired
- 1980-11-07 US US06/204,846 patent/US4341793A/en not_active Expired - Lifetime
- 1980-11-13 AU AU64354/80A patent/AU540343B2/en not_active Ceased
- 1980-11-14 JP JP16063980A patent/JPS5683484A/ja active Pending
- 1980-11-14 ZA ZA00807078A patent/ZA807078B/xx unknown
- 1980-11-14 IL IL61496A patent/IL61496A0/xx unknown
- 1980-11-14 NZ NZ195551A patent/NZ195551A/en unknown
- 1980-11-14 DK DK489180A patent/DK489180A/da unknown
- 1980-11-14 IE IE2371/80A patent/IE50475B1/en unknown
- 1980-11-14 ES ES496880A patent/ES496880A0/es active Granted
- 1980-11-14 CA CA000364738A patent/CA1161053A/en not_active Expired
-
1981
- 1981-11-24 ES ES507410A patent/ES507410A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0029320A2 (en) | 1981-05-27 |
| DK489180A (da) | 1981-05-16 |
| EP0029320A3 (en) | 1981-08-05 |
| NZ195551A (en) | 1984-11-09 |
| EP0029320B1 (en) | 1985-07-10 |
| IL61496A0 (en) | 1980-12-31 |
| CA1161053A (en) | 1984-01-24 |
| AU540343B2 (en) | 1984-11-15 |
| ES8207165A1 (es) | 1982-09-01 |
| ATE14222T1 (de) | 1985-07-15 |
| ES496880A0 (es) | 1982-02-16 |
| DE3070865D1 (en) | 1985-08-14 |
| AU6435480A (en) | 1981-05-21 |
| IE802371L (en) | 1981-05-15 |
| IE50475B1 (en) | 1986-04-30 |
| JPS5683484A (en) | 1981-07-08 |
| US4341793A (en) | 1982-07-27 |
| ES507410A0 (es) | 1982-09-01 |
| ZA807078B (en) | 1981-10-28 |
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