ES8200898A1 - Procedimiento para la obtencion de derivados de la tiazolo (3,4-b)isoquinoleina - Google Patents

Procedimiento para la obtencion de derivados de la tiazolo (3,4-b)isoquinoleina

Info

Publication number
ES8200898A1
ES8200898A1 ES497398A ES497398A ES8200898A1 ES 8200898 A1 ES8200898 A1 ES 8200898A1 ES 497398 A ES497398 A ES 497398A ES 497398 A ES497398 A ES 497398A ES 8200898 A1 ES8200898 A1 ES 8200898A1
Authority
ES
Spain
Prior art keywords
radical
isoquinoline derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497398A
Other languages
English (en)
Other versions
ES497398A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7929751A external-priority patent/FR2470772A1/fr
Priority claimed from FR8022260A external-priority patent/FR2492379A2/fr
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES8200898A1 publication Critical patent/ES8200898A1/es
Publication of ES497398A0 publication Critical patent/ES497398A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA TIAZOLO (3,4-B) ISOQUINOLEINA, DE FORMULA GENERAL (I), DONDE A REPRESENTA UN RADICAL ISOQUINOL-8, HIDROXIMETIL-3 ISOQUINOLIL-5, TIENILO, QUINOLIL-5, TIENOPIRIDILO, TIAZOLILO, IMIDAZOLILO O PIRACIMILO, Y LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA AMINA A-NH2 DONDE A TIENE ELSIGNIFICADO ATOMO DE CLO, UN RADICAL ALQUILTIO CON 1 A 4 ATOMOS DE CARBONO O UN RADICAL BENCILTIO, Y A1O REPRESENTA UN ANION. CUANDO R1 REPRESENTA UN ATOMO DE CLORO Y A1O UN ION CLORURO, LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO, TAL COMO EL ACETONITRILO, EN PRESENCIA DE UNA BASE, TAL COMO LA TRIETILAMINA. CUANDO R1 REPRESENTA UN RADICAL ALQUILTIO O BENCILTIO Y A1O UN ION YODURO, SULFATO, TETRAFLUORCARBONATO O FLUIOR SULFONATO, LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO BASICO, TAL COMO LA PIRIDINA. EL PROCESO OFRECE VARIANTES. DE USO EN PREPARADOS FARMACEUTICOS CON ACTIVIDAD ANALGESICA Y ANTIPIRETICA.
ES497398A 1979-12-04 1980-12-03 Procedimiento para la obtencion de derivados de la tiazolo (3,4-b)isoquinoleina Granted ES497398A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7929751A FR2470772A1 (fr) 1979-12-04 1979-12-04 Nouveaux derives de l'isoquinoleine, leur preparation et les medicaments qui les contiennent
FR8022260A FR2492379A2 (fr) 1980-10-17 1980-10-17 Nouveaux derives de l'isoquinoleine, leur preparation et les medicaments qui les contiennent

Publications (2)

Publication Number Publication Date
ES8200898A1 true ES8200898A1 (es) 1981-11-16
ES497398A0 ES497398A0 (es) 1981-11-16

Family

ID=26221466

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497398A Granted ES497398A0 (es) 1979-12-04 1980-12-03 Procedimiento para la obtencion de derivados de la tiazolo (3,4-b)isoquinoleina

Country Status (11)

Country Link
US (1) US4363909A (es)
EP (1) EP0030198B1 (es)
AU (1) AU6496380A (es)
CA (1) CA1155117A (es)
DE (1) DE3062230D1 (es)
DK (1) DK516180A (es)
ES (1) ES497398A0 (es)
FI (1) FI803775L (es)
HU (1) HU181232B (es)
NO (1) NO803656L (es)
NZ (1) NZ195721A (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA05403A (fr) * 1975-08-06 1981-02-28 Rhone Poulenc Ind Nouveaux dérivés de la thiazolo [3,4-b] isoquinoléine et leur procédé de préparation.
FR2351655A1 (fr) * 1976-05-18 1977-12-16 Rhone Poulenc Ind Nouveau derive de la thiazolo (3,4-b) isoquinoleine, sa preparation et les compositions qui le contiennent
FR2320098A1 (fr) * 1975-08-06 1977-03-04 Rhone Poulenc Ind Nouveaux derives de la thiazilo (3,4-b) isoquinoleine, leur preparation et les compositions qui les contiennent
FR2378030A1 (fr) * 1977-01-20 1978-08-18 Rhone Poulenc Ind Nouveau derive de l'isoquinoleine, sa preparation et les compositions qui le contiennent
NL7800383A (nl) * 1977-01-20 1978-07-24 Rhone Poulenc Ind Nieuwe isochinolinederivaten, de bereiding ervan en preparaten die de isochinolinederivaten bevatten.

Also Published As

Publication number Publication date
US4363909A (en) 1982-12-14
EP0030198B1 (fr) 1983-03-02
NZ195721A (en) 1982-09-14
HU181232B (en) 1983-06-28
NO803656L (no) 1981-06-05
DK516180A (da) 1981-06-05
FI803775L (fi) 1981-06-05
CA1155117A (fr) 1983-10-11
AU6496380A (en) 1981-06-11
EP0030198A1 (fr) 1981-06-10
ES497398A0 (es) 1981-11-16
DE3062230D1 (en) 1983-04-07

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