ES8200872A1 - Substituted-phenylpyridines and preparation - Google Patents
Substituted-phenylpyridines and preparationInfo
- Publication number
- ES8200872A1 ES8200872A1 ES497787A ES497787A ES8200872A1 ES 8200872 A1 ES8200872 A1 ES 8200872A1 ES 497787 A ES497787 A ES 497787A ES 497787 A ES497787 A ES 497787A ES 8200872 A1 ES8200872 A1 ES 8200872A1
- Authority
- ES
- Spain
- Prior art keywords
- pyridine
- hydrogen
- phenyl
- methyl
- phenylpyridines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
4(or 3)-(3,4-Dihydroxyphenyl)- pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4- dimethoxyphenyl) pyridine, preferably by heating with aqueous hydrogen bromide. 4(or 3)-[3,4-di-(OR)-phenyl] pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid- addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di(OR)-phenyl] pyridine, where R is hydrogen or methyl, is shown for comparative purposes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10585179A | 1979-12-20 | 1979-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8200872A1 true ES8200872A1 (en) | 1981-11-16 |
| ES497787A0 ES497787A0 (en) | 1981-11-16 |
Family
ID=22308136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497787A Granted ES497787A0 (en) | 1979-12-20 | 1980-12-16 | A PROCEDURE TO PREPARE 4 (O3) - (3,4-DIHIDROXIFENIL) PIRIDINA |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS56118064A (en) |
| KR (1) | KR830004249A (en) |
| AR (1) | AR226442A1 (en) |
| AT (1) | AT374459B (en) |
| AU (1) | AU6515880A (en) |
| BE (1) | BE886675A (en) |
| DE (1) | DE3047615A1 (en) |
| DK (1) | DK536680A (en) |
| ES (1) | ES497787A0 (en) |
| FI (1) | FI803913L (en) |
| FR (1) | FR2471976A1 (en) |
| GB (1) | GB2065651B (en) |
| IL (1) | IL61676A (en) |
| IT (1) | IT1194006B (en) |
| LU (1) | LU83007A1 (en) |
| NL (1) | NL8006785A (en) |
| NO (1) | NO803790L (en) |
| NZ (1) | NZ195758A (en) |
| PH (1) | PH16466A (en) |
| PT (1) | PT72206B (en) |
| SE (1) | SE8008887L (en) |
| ZA (1) | ZA807781B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1183046A (en) * | 1966-06-28 | 1970-03-04 | Allen & Hanburys Ltd | Novel Heterocyclic Compounds |
-
1980
- 1980-12-04 NZ NZ195758A patent/NZ195758A/en unknown
- 1980-12-08 AU AU65158/80A patent/AU6515880A/en not_active Abandoned
- 1980-12-09 IL IL61676A patent/IL61676A/en unknown
- 1980-12-12 ZA ZA00807781A patent/ZA807781B/en unknown
- 1980-12-15 IT IT26661/80A patent/IT1194006B/en active
- 1980-12-15 NL NL8006785A patent/NL8006785A/en not_active Application Discontinuation
- 1980-12-15 FI FI803913A patent/FI803913L/en not_active Application Discontinuation
- 1980-12-15 GB GB8040121A patent/GB2065651B/en not_active Expired
- 1980-12-16 ES ES497787A patent/ES497787A0/en active Granted
- 1980-12-16 AT AT0613180A patent/AT374459B/en not_active IP Right Cessation
- 1980-12-16 NO NO803790A patent/NO803790L/en unknown
- 1980-12-16 BE BE1/10076A patent/BE886675A/en not_active IP Right Cessation
- 1980-12-16 LU LU83007A patent/LU83007A1/en unknown
- 1980-12-16 PT PT72206A patent/PT72206B/en unknown
- 1980-12-16 FR FR8026689A patent/FR2471976A1/en not_active Withdrawn
- 1980-12-17 DK DK536680A patent/DK536680A/en unknown
- 1980-12-17 AR AR283675A patent/AR226442A1/en active
- 1980-12-17 KR KR1019800004813A patent/KR830004249A/en unknown
- 1980-12-17 SE SE8008887A patent/SE8008887L/en not_active Application Discontinuation
- 1980-12-17 JP JP17867080A patent/JPS56118064A/en active Pending
- 1980-12-17 DE DE19803047615 patent/DE3047615A1/en not_active Withdrawn
- 1980-12-18 PH PH25004A patent/PH16466A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR830004249A (en) | 1983-07-09 |
| SE8008887L (en) | 1981-06-21 |
| DK536680A (en) | 1981-06-21 |
| DE3047615A1 (en) | 1981-09-17 |
| NL8006785A (en) | 1981-07-16 |
| PT72206A (en) | 1981-01-01 |
| FI803913L (en) | 1981-06-21 |
| FR2471976A1 (en) | 1981-06-26 |
| IT8026661A0 (en) | 1980-12-15 |
| IL61676A (en) | 1984-02-29 |
| GB2065651A (en) | 1981-07-01 |
| ATA613180A (en) | 1983-09-15 |
| AU6515880A (en) | 1981-06-25 |
| IL61676A0 (en) | 1981-01-30 |
| AT374459B (en) | 1984-04-25 |
| NO803790L (en) | 1981-06-22 |
| BE886675A (en) | 1981-06-16 |
| JPS56118064A (en) | 1981-09-16 |
| ZA807781B (en) | 1981-12-30 |
| ES497787A0 (en) | 1981-11-16 |
| NZ195758A (en) | 1984-07-06 |
| PT72206B (en) | 1981-10-28 |
| IT1194006B (en) | 1988-08-31 |
| PH16466A (en) | 1983-10-20 |
| GB2065651B (en) | 1983-10-05 |
| AR226442A1 (en) | 1982-07-15 |
| LU83007A1 (en) | 1981-07-23 |
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