SE8008887L - SUBSTITUTED PHENYL PYRIDINES AND PROCEDURES FOR PREPARING AND USING THEREOF - Google Patents
SUBSTITUTED PHENYL PYRIDINES AND PROCEDURES FOR PREPARING AND USING THEREOFInfo
- Publication number
- SE8008887L SE8008887L SE8008887A SE8008887A SE8008887L SE 8008887 L SE8008887 L SE 8008887L SE 8008887 A SE8008887 A SE 8008887A SE 8008887 A SE8008887 A SE 8008887A SE 8008887 L SE8008887 L SE 8008887L
- Authority
- SE
- Sweden
- Prior art keywords
- pyridine
- procedures
- preparing
- substituted phenyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
4(or 3)-(3,4-Dihydroxyphenyl)- pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4- dimethoxyphenyl) pyridine, preferably by heating with aqueous hydrogen bromide. 4(or 3)-[3,4-di-(OR)-phenyl] pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid- addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di(OR)-phenyl] pyridine, where R is hydrogen or methyl, is shown for comparative purposes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10585179A | 1979-12-20 | 1979-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8008887L true SE8008887L (en) | 1981-06-21 |
Family
ID=22308136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8008887A SE8008887L (en) | 1979-12-20 | 1980-12-17 | SUBSTITUTED PHENYL PYRIDINES AND PROCEDURES FOR PREPARING AND USING THEREOF |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS56118064A (en) |
| KR (1) | KR830004249A (en) |
| AR (1) | AR226442A1 (en) |
| AT (1) | AT374459B (en) |
| AU (1) | AU6515880A (en) |
| BE (1) | BE886675A (en) |
| DE (1) | DE3047615A1 (en) |
| DK (1) | DK536680A (en) |
| ES (1) | ES497787A0 (en) |
| FI (1) | FI803913L (en) |
| FR (1) | FR2471976A1 (en) |
| GB (1) | GB2065651B (en) |
| IL (1) | IL61676A (en) |
| IT (1) | IT1194006B (en) |
| LU (1) | LU83007A1 (en) |
| NL (1) | NL8006785A (en) |
| NO (1) | NO803790L (en) |
| NZ (1) | NZ195758A (en) |
| PH (1) | PH16466A (en) |
| PT (1) | PT72206B (en) |
| SE (1) | SE8008887L (en) |
| ZA (1) | ZA807781B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1183046A (en) * | 1966-06-28 | 1970-03-04 | Allen & Hanburys Ltd | Novel Heterocyclic Compounds |
-
1980
- 1980-12-04 NZ NZ195758A patent/NZ195758A/en unknown
- 1980-12-08 AU AU65158/80A patent/AU6515880A/en not_active Abandoned
- 1980-12-09 IL IL61676A patent/IL61676A/en unknown
- 1980-12-12 ZA ZA00807781A patent/ZA807781B/en unknown
- 1980-12-15 IT IT26661/80A patent/IT1194006B/en active
- 1980-12-15 FI FI803913A patent/FI803913L/en not_active Application Discontinuation
- 1980-12-15 NL NL8006785A patent/NL8006785A/en not_active Application Discontinuation
- 1980-12-15 GB GB8040121A patent/GB2065651B/en not_active Expired
- 1980-12-16 PT PT72206A patent/PT72206B/en unknown
- 1980-12-16 NO NO803790A patent/NO803790L/en unknown
- 1980-12-16 BE BE1/10076A patent/BE886675A/en not_active IP Right Cessation
- 1980-12-16 AT AT0613180A patent/AT374459B/en not_active IP Right Cessation
- 1980-12-16 ES ES497787A patent/ES497787A0/en active Granted
- 1980-12-16 FR FR8026689A patent/FR2471976A1/en not_active Withdrawn
- 1980-12-16 LU LU83007A patent/LU83007A1/en unknown
- 1980-12-17 JP JP17867080A patent/JPS56118064A/en active Pending
- 1980-12-17 KR KR1019800004813A patent/KR830004249A/en unknown
- 1980-12-17 DK DK536680A patent/DK536680A/en unknown
- 1980-12-17 DE DE19803047615 patent/DE3047615A1/en not_active Withdrawn
- 1980-12-17 AR AR283675A patent/AR226442A1/en active
- 1980-12-17 SE SE8008887A patent/SE8008887L/en not_active Application Discontinuation
- 1980-12-18 PH PH25004A patent/PH16466A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA807781B (en) | 1981-12-30 |
| ES8200872A1 (en) | 1981-11-16 |
| AU6515880A (en) | 1981-06-25 |
| BE886675A (en) | 1981-06-16 |
| AR226442A1 (en) | 1982-07-15 |
| IT8026661A0 (en) | 1980-12-15 |
| NL8006785A (en) | 1981-07-16 |
| NO803790L (en) | 1981-06-22 |
| JPS56118064A (en) | 1981-09-16 |
| PH16466A (en) | 1983-10-20 |
| IL61676A0 (en) | 1981-01-30 |
| DE3047615A1 (en) | 1981-09-17 |
| LU83007A1 (en) | 1981-07-23 |
| AT374459B (en) | 1984-04-25 |
| NZ195758A (en) | 1984-07-06 |
| ES497787A0 (en) | 1981-11-16 |
| KR830004249A (en) | 1983-07-09 |
| PT72206B (en) | 1981-10-28 |
| PT72206A (en) | 1981-01-01 |
| IL61676A (en) | 1984-02-29 |
| FR2471976A1 (en) | 1981-06-26 |
| GB2065651B (en) | 1983-10-05 |
| DK536680A (en) | 1981-06-21 |
| ATA613180A (en) | 1983-09-15 |
| IT1194006B (en) | 1988-08-31 |
| FI803913L (en) | 1981-06-21 |
| GB2065651A (en) | 1981-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8008887-5 |