ES8106720A1 - Un procedimiento para la preparacion de diariltiofenos. - Google Patents

Un procedimiento para la preparacion de diariltiofenos.

Info

Publication number
ES8106720A1
ES8106720A1 ES80494131A ES494131A ES8106720A1 ES 8106720 A1 ES8106720 A1 ES 8106720A1 ES 80494131 A ES80494131 A ES 80494131A ES 494131 A ES494131 A ES 494131A ES 8106720 A1 ES8106720 A1 ES 8106720A1
Authority
ES
Spain
Prior art keywords
antiinflammatory
substituted
thiophenes
diaryl
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES80494131A
Other languages
English (en)
Other versions
ES494131A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES8106720A1 publication Critical patent/ES8106720A1/es
Publication of ES494131A0 publication Critical patent/ES494131A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIARILTIOFENOS, DE FORMULA (I), DONDE R ELEVADO A 1 ES MONO O POLIFLUOR(ALQUILO C1-C6) O ALQUILO C1-C6; "N" ES 0, 1 O 2; R CUBO Y R ELEVADO A 4 SON INDEPENDIENTEMENTE PIRIDILO O UN RADICAL DE FORMULA (II), DONDE X ES H,M F, CL, BR, NO2, ALQUILO C1-C2 O ALCOXI C1-C2; Y ES H, F O CL, CON LA CONDICION DE QUE CUANDO Y ES F O CL, ENTONCES X ES F O CL; R ELEVADO A 5 ES H, ALQUILO C1-C4 O ALILO; CON LAS EXCEPCIONES SIGUIENTES: CUANDO R ELEVADO A 1 ES ALQUILO C1-C6, R CUBO Y R ELEVADO A 4 NO PUEDEN SER AMBOS FENILO, Y CUANDO "N" ES 2, R CUBO Y R ELEVADO A 4 NO PUEDEN SER AMBOS FENILO. CONSISTE EN PREPARAR ADECUADAMENTE UN COMPUESTO DE FORMULA GENERAL (III), DONDE R ELEVADO A 5'' ES R ELEVADO A 5 O BR; W ES H O BR, Y CUANDO R ELEVADO A 5'' ES R ELEVADO A 5 Y W ES H, SE LE HACE REACCIONAR YA SEA DIRECTAMENTE CON UN COMPUESTO R ELEVADO A 1 SZ, DONDE Z ES HALOGENO, O PRIMERO CON UN REACTIVO METALANTE Y LUEGO CON UN COMPUESTO R ELEVADO A 1 ST, DONDE T ES HALOGENO O -SRELEVADO A 1, Y CUANDO R ELEVADO A 5'' ES R ELEVADO A 5 Y W ES BR, SE LE HACE REACCIONAR PRIMERO CON UN REACTIVO METALANTE Y LUEGO CON UN COMPUESTO R ELEVADO A 1 ST, SIENDO T HALOGENO O -SR ELEVADO A 1, Y CUANDO R ELEVADO A 5'' ES BR SE LE HACE REACCIONAR CON UN AGENTE METALANTE Y A CONTINUACION CON UN HALURO DE ALQUILO DE FORMULA R ELEVADO A 5-X'' DONDE X'' ES HALOGENO O -OSO3R ELEVADO A 5. *FORMULA*
ES80494131A 1979-08-09 1980-08-08 Un procedimiento para la preparacion de diariltiofenos. Granted ES494131A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6506979A 1979-08-09 1979-08-09
US06/159,236 US4302461A (en) 1979-08-09 1980-06-20 Antiinflammatory 5-substituted-2,3-diarylthiophenes

Publications (2)

Publication Number Publication Date
ES8106720A1 true ES8106720A1 (es) 1981-09-01
ES494131A0 ES494131A0 (es) 1981-09-01

Family

ID=26745173

Family Applications (1)

Application Number Title Priority Date Filing Date
ES80494131A Granted ES494131A0 (es) 1979-08-09 1980-08-08 Un procedimiento para la preparacion de diariltiofenos.

Country Status (20)

Country Link
US (1) US4302461A (es)
EP (1) EP0024042B1 (es)
AR (1) AR227288A1 (es)
AT (1) ATE17725T1 (es)
AU (1) AU533376B2 (es)
CA (1) CA1151650A (es)
DE (1) DE3071385D1 (es)
DK (1) DK301180A (es)
ES (1) ES494131A0 (es)
FI (1) FI802506A (es)
GR (1) GR69912B (es)
HU (1) HU182185B (es)
IE (1) IE51387B1 (es)
IL (1) IL60800A (es)
MX (1) MX6600E (es)
NO (1) NO152091C (es)
NZ (1) NZ194607A (es)
PH (1) PH16821A (es)
PT (1) PT71684B (es)
YU (2) YU199880A (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381311A (en) * 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols
EP0055471A1 (en) * 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines
ATE17480T1 (de) * 1982-03-03 1986-02-15 Du Pont Entzuendungshemmende und/oder schmerzstillende 2,3-diaryl-5-halo thiophene.
US4590205A (en) * 1982-03-03 1986-05-20 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes
US4820827A (en) * 1982-03-03 1989-04-11 E. I. Du Pont De Nemours And Company 2,3-diaryl-5-bromothiophene compounds of use for the treatment of inflammaton and dysmenorrhea
US4749712A (en) * 1983-03-01 1988-06-07 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 5-alkylthiophenes
EP0273602A1 (en) * 1986-12-05 1988-07-06 Eli Lilly And Company 3-Cyano-4-arylthiophenes
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
WO1994015932A1 (en) * 1993-01-15 1994-07-21 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US6492413B2 (en) 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
WO1996026204A1 (fr) * 1995-02-24 1996-08-29 Kaken Pharmaceutical Co., Ltd. Derives de phenylamidinothiophene et agent antiphlogistique les contenant
US5691374A (en) * 1995-05-18 1997-11-25 Merck Frosst Canada Inc. Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors
EP0828718A1 (en) 1995-06-02 1998-03-18 G.D. SEARLE & CO. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6515014B2 (en) 1995-06-02 2003-02-04 G. D. Searle & Co. Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6512121B2 (en) 1998-09-14 2003-01-28 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US7329401B2 (en) * 2002-04-15 2008-02-12 The Regents Of The University Of California Cyclooxygenase-2 selective agents useful as imaging probes and related methods
FR2880890B1 (fr) * 2005-01-19 2007-03-30 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
FR2881744B1 (fr) 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
CA2603534C (en) * 2005-03-04 2014-02-04 Fan Wu Design and synthesis of novel antimicrobials
CN101429189B (zh) * 2008-12-24 2014-07-23 沈阳药科大学 2，3-二取代芳基噻吩类衍生物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2639286A (en) * 1948-07-29 1953-05-19 Universal Oil Prod Co Alkylation of heterocyclic organic compounds
US3531497A (en) * 1967-02-21 1970-09-29 Upjohn Co 2,4,5 - triphenyl - (and substituted triphenyl) - 3 - acetonitriles of pyrrole
GB1271082A (en) * 1968-05-07 1972-04-19 Wyeth John & Brother Ltd Furan, pyrrole and thiophene derivatives

Also Published As

Publication number Publication date
MX6600E (es) 1985-08-14
NO802384L (no) 1981-02-10
NZ194607A (en) 1984-05-31
AU533376B2 (en) 1983-11-17
NO152091C (no) 1985-07-31
US4302461A (en) 1981-11-24
GR69912B (es) 1982-07-21
PH16821A (en) 1984-03-06
PT71684A (en) 1980-09-01
PT71684B (en) 1982-04-06
IL60800A (en) 1985-02-28
EP0024042A1 (en) 1981-02-18
YU199880A (en) 1983-04-30
IL60800A0 (en) 1980-10-26
NO152091B (no) 1985-04-22
DK301180A (da) 1981-02-10
IE51387B1 (en) 1986-12-24
IE801668L (en) 1981-02-09
YU5783A (en) 1983-06-30
FI802506A (fi) 1981-02-10
AU6133480A (en) 1982-02-18
HU182185B (en) 1983-12-28
DE3071385D1 (en) 1986-03-13
EP0024042B1 (en) 1986-01-29
ATE17725T1 (de) 1986-02-15
AR227288A1 (es) 1982-10-15
CA1151650A (en) 1983-08-09
ES494131A0 (es) 1981-09-01

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