ES8106511A1 - Procedimiento para la preparacion de acidos alcoxi benzofu- ran carboxilicos - Google Patents
Procedimiento para la preparacion de acidos alcoxi benzofu- ran carboxilicosInfo
- Publication number
- ES8106511A1 ES8106511A1 ES493763A ES493763A ES8106511A1 ES 8106511 A1 ES8106511 A1 ES 8106511A1 ES 493763 A ES493763 A ES 493763A ES 493763 A ES493763 A ES 493763A ES 8106511 A1 ES8106511 A1 ES 8106511A1
- Authority
- ES
- Spain
- Prior art keywords
- salts
- alkoxy
- esters
- carboxylic acids
- hypolipidemic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE ACIDOS ALCOXIBENZOFURAN CARBOXILICOS. CONSTA DE LAS SIGUIENTES ETAPAS: 1. REACCION DE UN COMPUESTO (I) CON BROMO, HIDROLIZANDO EL PRODUCTO BROMADO BAJO CONDICIONES BASICAS. 2. REACCION DE UN ORTO-HIDROXIBENZALEDEHIDO (II) CON UN R2-HALURO, OBTENIENDOSE EL CORRESPONDIENTE ORTO-HIDROXIBENZOLDEHIDO ALCOXI-SUSTITUIDO, QUE SE CICLIZA POR REACCION CON UN ALQUIL HALOACETATO INFERIOR EN PRESENCIA DE UNA BASE Y A CONTINUACION SE DESHIDRATA EL PRODUCTO RESULTANTE EN PRESENCIA DE UN ACIDO. 3. REACCION DEL ORTO-HIDROXIBENZALDEHIDO OBTENIDO CON UN HALOMALONATO DE ALQUILO INFERIOR EN PRESENCIA DE UNA BASE. 4. ESTERIFICACION DE UN ACIDO OBTENIDO EN 1 .-3 . POR REACCION CON UN R1-HALURO EN PRESENCIA DE UNA BASE. 5. FORMACION DE UNA SAL FARMACEUTICAMENTE ACEPTABLE, POR REACCION CON UNA BASE FARMACEUTICAMENTE ACEPTABLE. *FORMULA* *
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/067,243 US4229467A (en) | 1979-08-16 | 1979-08-16 | Alkoxy benzofuran carboxylic acids and salts and esters thereof as hypolipidemic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8106511A1 true ES8106511A1 (es) | 1981-08-01 |
ES493763A0 ES493763A0 (es) | 1981-08-01 |
Family
ID=22074675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES493763A Granted ES493763A0 (es) | 1979-08-16 | 1980-07-28 | Procedimiento para la preparacion de acidos alcoxi benzofu- ran carboxilicos |
Country Status (12)
Country | Link |
---|---|
US (1) | US4229467A (es) |
JP (1) | JPS5636476A (es) |
AU (1) | AU6045880A (es) |
BE (1) | BE884782A (es) |
DE (1) | DE3028197A1 (es) |
ES (1) | ES493763A0 (es) |
FR (1) | FR2463136A1 (es) |
GB (1) | GB2056446A (es) |
IL (1) | IL60592A0 (es) |
IT (1) | IT1133039B (es) |
NL (1) | NL8004148A (es) |
ZA (1) | ZA804058B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1141663A (en) * | 1979-09-06 | 1983-02-22 | Yukihisa Ishii | Ophthalmic solution for intraocular pressure adjustment |
US4822803A (en) * | 1983-10-31 | 1989-04-18 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis |
US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
US4933351A (en) * | 1983-10-31 | 1990-06-12 | Merck Frosst Canada, Inc. | Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis |
EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
US4745127A (en) * | 1983-10-31 | 1988-05-17 | Merck Frosst Canada, Inc. | Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis |
US4751306A (en) * | 1985-09-09 | 1988-06-14 | E. I. Du Pont De Nemours And Company | Imide intermediates for the preparation of analgesic and/or antagonist octahydrobenzofuroisoquinolines |
DE102006060597A1 (de) * | 2006-12-21 | 2008-06-26 | Merck Patent Gmbh | Verfahren zur Herstellung von Benzofuran-2-carboxamiden |
CN112645917B (zh) * | 2020-12-16 | 2022-12-20 | 苏州阿德旺斯新材料有限公司 | 一种光响应相变材料及应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1008260A (en) | 1961-05-19 | 1965-10-27 | Byk Gulden Lomberg Chem Fab | Process for the production of substituted benzofuran derivatives |
DE2828396A1 (de) * | 1977-06-30 | 1979-01-11 | Shell Int Research | Benzofuran- bzw. dihydrobenzofuranderivate |
-
1979
- 1979-08-16 US US06/067,243 patent/US4229467A/en not_active Expired - Lifetime
-
1980
- 1980-07-04 ZA ZA00804058A patent/ZA804058B/xx unknown
- 1980-07-15 IL IL60592A patent/IL60592A0/xx unknown
- 1980-07-16 AU AU60458/80A patent/AU6045880A/en not_active Abandoned
- 1980-07-18 NL NL8004148A patent/NL8004148A/nl not_active Application Discontinuation
- 1980-07-25 DE DE19803028197 patent/DE3028197A1/de not_active Withdrawn
- 1980-07-28 ES ES493763A patent/ES493763A0/es active Granted
- 1980-08-01 GB GB8025190A patent/GB2056446A/en not_active Withdrawn
- 1980-08-12 JP JP10991180A patent/JPS5636476A/ja active Pending
- 1980-08-12 IT IT49477/80A patent/IT1133039B/it active
- 1980-08-14 FR FR8017998A patent/FR2463136A1/fr not_active Withdrawn
- 1980-08-14 BE BE0/201753A patent/BE884782A/fr unknown
Also Published As
Publication number | Publication date |
---|---|
FR2463136A1 (fr) | 1981-02-20 |
IT8049477A0 (it) | 1980-08-12 |
DE3028197A1 (de) | 1981-03-12 |
IL60592A0 (en) | 1980-09-16 |
BE884782A (fr) | 1980-12-01 |
GB2056446A (en) | 1981-03-18 |
NL8004148A (nl) | 1981-02-18 |
AU6045880A (en) | 1981-02-19 |
JPS5636476A (en) | 1981-04-09 |
ZA804058B (en) | 1981-07-29 |
ES493763A0 (es) | 1981-08-01 |
IT1133039B (it) | 1986-07-09 |
US4229467A (en) | 1980-10-21 |
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