ES8106309A1 - Un procedimiento para la preparacion de acido 9-o-metilcla- vulanico - Google Patents

Un procedimiento para la preparacion de acido 9-o-metilcla- vulanico

Info

Publication number
ES8106309A1
ES8106309A1 ES494158A ES494158A ES8106309A1 ES 8106309 A1 ES8106309 A1 ES 8106309A1 ES 494158 A ES494158 A ES 494158A ES 494158 A ES494158 A ES 494158A ES 8106309 A1 ES8106309 A1 ES 8106309A1
Authority
ES
Spain
Prior art keywords
vivo hydrolysable
ester group
pharmaceutically acceptable
acceptable salt
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494158A
Other languages
English (en)
Other versions
ES494158A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8106309A1 publication Critical patent/ES8106309A1/es
Publication of ES494158A0 publication Critical patent/ES494158A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDO 9-0-METILCLAVULANICO, O UNA SAL FARMACOLOGICAMENTE COMPATIBLE, O UN ESTER HIDROLIZABLE "IN-VIVO" DEL MISMO. SE TRATA UN ESTER DE ACIDO CLAVULANICO ELIMINABLE CON YODURO O BROMURO DE METILO EN DICLOROMETANO, EN PRESENCIA DE OXIDO DE PLATA Y TAMIZ MOLECULAR O SULFATO CALCICO, A TEMPERATURA AMBIENTE O SUPERIOR. EL PRODUCTO OBTENIDO SE TRANSFORMA EN EL ACIDO POR HIDROLISIS, POR HIDROGENOLISIS CATALITICA, O BIOQUIMICAMENTE, POR TRATAMIENTO CON ENZIMAS AISLADAS O "IN-VIVO". A
ES494158A 1979-08-11 1980-08-11 Un procedimiento para la preparacion de acido 9-o-metilcla- vulanico Granted ES494158A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7928020 1979-08-11
GB7934526 1979-10-04

Publications (2)

Publication Number Publication Date
ES8106309A1 true ES8106309A1 (es) 1981-08-01
ES494158A0 ES494158A0 (es) 1981-08-01

Family

ID=26272524

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494158A Granted ES494158A0 (es) 1979-08-11 1980-08-11 Un procedimiento para la preparacion de acido 9-o-metilcla- vulanico

Country Status (12)

Country Link
EP (1) EP0024123B1 (es)
AU (1) AU531664B2 (es)
CA (1) CA1152999A (es)
DE (1) DE3062347D1 (es)
DK (1) DK344380A (es)
ES (1) ES494158A0 (es)
FI (1) FI802501A (es)
GR (1) GR69936B (es)
IE (1) IE50089B1 (es)
IL (1) IL60690A0 (es)
NO (1) NO802376L (es)
NZ (1) NZ194551A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698736A (en) * 1997-01-31 1997-12-16 Akzo Nobel Nv High temperature, catalytic Friedel-Crafts synthesis of benzene phosphorus dichloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573503A (en) * 1975-12-17 1980-08-28 Glaxo Lab Ltd Clavulanic acid derivatives
IL53465A (en) * 1976-12-11 1980-11-30 Beecham Group Ltd Process for the preparation of clavulanic acid ethers and some novel compounds of this type

Also Published As

Publication number Publication date
ES494158A0 (es) 1981-08-01
AU531664B2 (en) 1983-09-01
NO802376L (no) 1981-02-12
IE801675L (en) 1981-02-11
CA1152999A (en) 1983-08-30
EP0024123A1 (en) 1981-02-25
NZ194551A (en) 1983-03-15
FI802501A (fi) 1981-02-12
AU6119780A (en) 1981-02-19
DE3062347D1 (en) 1983-04-21
GR69936B (es) 1982-07-21
IE50089B1 (en) 1986-02-05
DK344380A (da) 1981-02-12
EP0024123B1 (en) 1983-03-16
IL60690A0 (en) 1980-09-16

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