ES8105735A1 - A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES8105735A1
ES8105735A1 ES493287A ES493287A ES8105735A1 ES 8105735 A1 ES8105735 A1 ES 8105735A1 ES 493287 A ES493287 A ES 493287A ES 493287 A ES493287 A ES 493287A ES 8105735 A1 ES8105735 A1 ES 8105735A1
Authority
ES
Spain
Prior art keywords
group
hydroximethyl
optionally
translation
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493287A
Other languages
Spanish (es)
Other versions
ES493287A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8641079A external-priority patent/JPS5612391A/en
Priority claimed from JP8641379A external-priority patent/JPS5612394A/en
Priority claimed from JP8641279A external-priority patent/JPS5612393A/en
Priority claimed from JP8641179A external-priority patent/JPS5612392A/en
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Publication of ES493287A0 publication Critical patent/ES493287A0/en
Publication of ES8105735A1 publication Critical patent/ES8105735A1/en
Expired legal-status Critical Current

Links

Abstract

PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTOTECINA OF GENERAL FORMULA (I), IN WHERE X'' REPRESENTS A GROUP COOR4 OR CH2OR, WHERE R RAISED TO 4 IS HO A LOWER ALKYL GROUP AND R IS H, OR AN ALKYL OR ACIL GROUP, YZ HO REPRESENTS AN ACILO GROUP, AS WELL AS ITS WATER SOLUBLE ALKALINE METAL SALTS. IT CONSISTS IN SUBMITTING THE CAMPOTOTECHINE TO A RADICAL REACTION, IN THE PRESENCE OF A METALLIC ION OF TRANSITION, WITH A HYDROXIMETHYL-COMPOUND OF GENERAL FORMULA (II), WHERE IT REPRESENTS H, COOH OR CH2OH, WITH THE AID OF SULFURIC ACID AND PEROID AQUEOUS, AND THEN, OPTIONALLY, TREAT THE RESULTING 7-HYDROXIMETHYL-CAMPTOTECHINE WITH A RENTAL OR CLARIFYING AGENT TO CONVERT THE 7-HYDROXIMETHYL GROUP TO A 7-ALCOXI-METHIOX-ACILOXI-GRUPO GROUP POSITION 20, U, OPTIONALLY, OXIDIZE THE RESULTING 7-HYDROXYMETHYLCAMPOTOTECHINE, AND THEN, OPTIONALLY, ESTERIFY THE 7-CARBOXI GROUP WITH A LOWER ALCONOL TO FORM 7-X''-CAMPTOTO UNDERGROUND ALCOXICARBONILO. *FORMULA* (Machine-translation by Google Translate, not legally binding)
ES493287A 1979-07-10 1980-07-10 A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES8105735A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP8641079A JPS5612391A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparaion
JP8641379A JPS5612394A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative
JP8641279A JPS5612393A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative
JP8641179A JPS5612392A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparation

Publications (2)

Publication Number Publication Date
ES493287A0 ES493287A0 (en) 1981-06-16
ES8105735A1 true ES8105735A1 (en) 1981-06-16

Family

ID=27467257

Family Applications (3)

Application Number Title Priority Date Filing Date
ES493287A Expired ES8105735A1 (en) 1979-07-10 1980-07-10 A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding)
ES499987A Expired ES8202012A1 (en) 1979-07-10 1981-03-02 A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding)
ES499986A Granted ES499986A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES499987A Expired ES8202012A1 (en) 1979-07-10 1981-03-02 A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding)
ES499986A Granted ES499986A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES

Country Status (1)

Country Link
ES (3) ES8105735A1 (en)

Also Published As

Publication number Publication date
ES499987A0 (en) 1982-01-01
ES493287A0 (en) 1981-06-16
ES8202011A1 (en) 1982-01-01
ES8202012A1 (en) 1982-01-01
ES499986A0 (en) 1982-01-01

Similar Documents

Publication Publication Date Title
UA7142A1 (en) Method for synthesizing derivatives of thien (3,2-с) pyridine or their salts
GB2252322B (en) Phosphonated oligomers and uses thereof
EP0101230A3 (en) Ferrous sulfide dissolution in acid with lowered gas formation
DE3063330D1 (en) Process for the isolation of a solid salt of p-hydroxymandelic acid; some salts of p-hydroxymandelic acid
JPS5544599A (en) Antiicorrosive agent for use in acid solution
ES8105735A1 (en) A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding)
GR75951B (en)
ES522240A0 (en) A METHOD FOR PREPARING QUINONAS.
ES8506607A1 (en) New azulene derivatives useful as anti-ulcerative and anti-flammatory agents.
ES8801298A3 (en) A procedure for the preparation of a platinum complex (Machine-translation by Google Translate, not legally binding)
JPS545974A (en) Imidazoledicaroboxylic acid derivatives
ES462973A1 (en) 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
ES381581A1 (en) Hexahydro-fluoren-2-yloxy alkanoic acids and esters thereof
DE2967550D1 (en) Method of making an organic metal salt or complex
AU9100482A (en) 2-phenyl morpholine derivatives
FR2424919A1 (en) SUBSTITUTE QUINOLEINECARBOXYLIC ACID AND ITS DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS
JPS525707A (en) Process for preparation of acrylic acid or methacrylic acid
JPS51138614A (en) Process for preparation of formic acid and its este r
PL270798A1 (en) Method for liquid/liquid extraction of iron from acidic water solutions
GB1355899A (en) Process for the preparation of methylcobalamine
ES8202049A1 (en) The production of a yellow iron oxide pigment.
KR940000426A (en) Method for preparing 2,4-diamino-1,3,5-trimethylbenzene-6-sulfonic acid
JPS5646835A (en) Preparation of organic titanium compound in aqueous system
ES458765A1 (en) Procedure to reduce the formation of costs in metal fosfatation. (Machine-translation by Google Translate, not legally binding)
JPS5479247A (en) Para-substituted phenylacetic acid derivative and its preparation