ES8105735A1 - A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES8105735A1 ES8105735A1 ES493287A ES493287A ES8105735A1 ES 8105735 A1 ES8105735 A1 ES 8105735A1 ES 493287 A ES493287 A ES 493287A ES 493287 A ES493287 A ES 493287A ES 8105735 A1 ES8105735 A1 ES 8105735A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- hydroximethyl
- optionally
- translation
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTOTECINA OF GENERAL FORMULA (I), IN WHERE X'' REPRESENTS A GROUP COOR4 OR CH2OR, WHERE R RAISED TO 4 IS HO A LOWER ALKYL GROUP AND R IS H, OR AN ALKYL OR ACIL GROUP, YZ HO REPRESENTS AN ACILO GROUP, AS WELL AS ITS WATER SOLUBLE ALKALINE METAL SALTS. IT CONSISTS IN SUBMITTING THE CAMPOTOTECHINE TO A RADICAL REACTION, IN THE PRESENCE OF A METALLIC ION OF TRANSITION, WITH A HYDROXIMETHYL-COMPOUND OF GENERAL FORMULA (II), WHERE IT REPRESENTS H, COOH OR CH2OH, WITH THE AID OF SULFURIC ACID AND PEROID AQUEOUS, AND THEN, OPTIONALLY, TREAT THE RESULTING 7-HYDROXIMETHYL-CAMPTOTECHINE WITH A RENTAL OR CLARIFYING AGENT TO CONVERT THE 7-HYDROXIMETHYL GROUP TO A 7-ALCOXI-METHIOX-ACILOXI-GRUPO GROUP POSITION 20, U, OPTIONALLY, OXIDIZE THE RESULTING 7-HYDROXYMETHYLCAMPOTOTECHINE, AND THEN, OPTIONALLY, ESTERIFY THE 7-CARBOXI GROUP WITH A LOWER ALCONOL TO FORM 7-X''-CAMPTOTO UNDERGROUND ALCOXICARBONILO. *FORMULA* (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641079A JPS5612391A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparaion |
JP8641379A JPS5612394A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
JP8641279A JPS5612393A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
JP8641179A JPS5612392A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES493287A0 ES493287A0 (en) | 1981-06-16 |
ES8105735A1 true ES8105735A1 (en) | 1981-06-16 |
Family
ID=27467257
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES493287A Expired ES8105735A1 (en) | 1979-07-10 | 1980-07-10 | A procedure for the preparation of campto tecina derivatives. (Machine-translation by Google Translate, not legally binding) |
ES499987A Expired ES8202012A1 (en) | 1979-07-10 | 1981-03-02 | A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding) |
ES499986A Granted ES499986A0 (en) | 1979-07-10 | 1981-03-02 | A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499987A Expired ES8202012A1 (en) | 1979-07-10 | 1981-03-02 | A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding) |
ES499986A Granted ES499986A0 (en) | 1979-07-10 | 1981-03-02 | A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES |
Country Status (1)
Country | Link |
---|---|
ES (3) | ES8105735A1 (en) |
-
1980
- 1980-07-10 ES ES493287A patent/ES8105735A1/en not_active Expired
-
1981
- 1981-03-02 ES ES499987A patent/ES8202012A1/en not_active Expired
- 1981-03-02 ES ES499986A patent/ES499986A0/en active Granted
Also Published As
Publication number | Publication date |
---|---|
ES499987A0 (en) | 1982-01-01 |
ES493287A0 (en) | 1981-06-16 |
ES8202011A1 (en) | 1982-01-01 |
ES8202012A1 (en) | 1982-01-01 |
ES499986A0 (en) | 1982-01-01 |
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