ES8100661A1 - Un procedimiento para la preparacion de 1-(3-bromo-isoxa- zol-5-il)-2-tercibutilaminoetanol - Google Patents
Un procedimiento para la preparacion de 1-(3-bromo-isoxa- zol-5-il)-2-tercibutilaminoetanolInfo
- Publication number
- ES8100661A1 ES8100661A1 ES487215A ES487215A ES8100661A1 ES 8100661 A1 ES8100661 A1 ES 8100661A1 ES 487215 A ES487215 A ES 487215A ES 487215 A ES487215 A ES 487215A ES 8100661 A1 ES8100661 A1 ES 8100661A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- preparation
- same
- isoxazole derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE 1-(3-BROMO-ISOXAZOL-5-IL)-2-TERCIBUTILAMINO-ETANOL. CONSTA DE LAS SIGUIENTES FASES: 1. REACCION DEL ACIDO 3-BROMO-5-ISOXAZOL-CARBOXILICO CON UN AGENTE CLORANTE. 2. REACCION DEL CLORURO OBTENIDO CON UN AGENTE DE ALQUILACION NUCLEOFILO PARA OBTENER LA CETONA CORRESPONDIENTE; SEGUIDO DE UNA HIDROLISIS Y DESCARBOXILACION. 3. REDUCCION DE LA CETONA OBTENIDA POR BROMACION. EL 1-(3-BROMO-ISOXAZOL-5-IL)-BROMOETANOL SE HACE REACCIONAR CON TERCIBUTILAMINA, OBTENIENDOSE EL 1-(3-BROMO-ISOXAZOL-5-IL)-2-TERCIBUTILAMINOETANOL. EN LA FASE FINAL DEL PROCESO EL 1-(3-BROMO-ISOXAZOL-5-IL)-2-BROMOETANOL SE TRANSFORMA OPCIONALMENTE EN 2-(3-BROMO-ISOXAZOL-5-IL)-OXIRANO Y A CONTINUACION SE TRATA CON TERCIBUTILAMINA. AGENTE BRONCODILATADOR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT31198/78A IT1160387B (it) | 1978-12-22 | 1978-12-22 | Derivato isossazolico, ad attivita' terapeutica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8100661A1 true ES8100661A1 (es) | 1980-12-01 |
| ES487215A0 ES487215A0 (es) | 1980-12-01 |
Family
ID=11233265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES487215A Granted ES487215A0 (es) | 1978-12-22 | 1979-12-21 | Un procedimiento para la preparacion de 1-(3-bromo-isoxa- zol-5-il)-2-tercibutilaminoetanol |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4276299A (es) |
| EP (1) | EP0016255B1 (es) |
| JP (2) | JPS55108862A (es) |
| AT (1) | ATE4806T1 (es) |
| AU (1) | AU532551B2 (es) |
| CA (1) | CA1129868A (es) |
| DE (1) | DE2966234D1 (es) |
| DK (1) | DK150541C (es) |
| ES (1) | ES487215A0 (es) |
| GR (1) | GR78203B (es) |
| IE (1) | IE49026B1 (es) |
| IL (1) | IL58828A (es) |
| IT (1) | IT1160387B (es) |
| MX (1) | MX9203180A (es) |
| YU (1) | YU40768B (es) |
| ZA (1) | ZA796464B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959382A (en) * | 1984-06-04 | 1990-09-25 | Merck & Co., Inc. | Use of certain compounds in livestock food as growth promotants for better feed utilization and improved carcass composition |
| US4929630A (en) * | 1986-03-14 | 1990-05-29 | Syntex (U.S.A.) Inc. | Transglutaminase inhibitors |
| US4912120A (en) * | 1986-03-14 | 1990-03-27 | Syntex (U.S.A.) Inc. | 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors |
| US6064993A (en) * | 1997-12-18 | 2000-05-16 | Pitney Bowes Inc. | Closed system virtual postage meter |
| US6874445B2 (en) * | 2003-03-17 | 2005-04-05 | Ralph F. Polimeni, Jr. | Pet feeder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE307356B (es) * | 1963-07-31 | 1969-01-07 | Shionogi & Co | |
| US3932426A (en) * | 1973-08-23 | 1976-01-13 | Shionogi & Co., Ltd. | 3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazole |
-
1978
- 1978-12-22 IT IT31198/78A patent/IT1160387B/it active
-
1979
- 1979-11-27 GR GR60611A patent/GR78203B/el unknown
- 1979-11-28 ZA ZA00796464A patent/ZA796464B/xx unknown
- 1979-11-29 IL IL58828A patent/IL58828A/xx unknown
- 1979-12-05 AT AT79104916T patent/ATE4806T1/de not_active IP Right Cessation
- 1979-12-05 DE DE7979104916T patent/DE2966234D1/de not_active Expired
- 1979-12-05 EP EP79104916A patent/EP0016255B1/en not_active Expired
- 1979-12-17 AU AU53888/79A patent/AU532551B2/en not_active Expired
- 1979-12-18 US US06/104,740 patent/US4276299A/en not_active Expired - Lifetime
- 1979-12-18 DK DK539079A patent/DK150541C/da not_active IP Right Cessation
- 1979-12-18 IE IE2460/79A patent/IE49026B1/en not_active IP Right Cessation
- 1979-12-19 JP JP16546779A patent/JPS55108862A/ja active Granted
- 1979-12-20 YU YU3128/79A patent/YU40768B/xx unknown
- 1979-12-21 ES ES487215A patent/ES487215A0/es active Granted
- 1979-12-21 CA CA342,697A patent/CA1129868A/en not_active Expired
-
1980
- 1980-08-22 US US06/180,422 patent/US4520200A/en not_active Expired - Lifetime
-
1986
- 1986-09-03 JP JP61206058A patent/JPS6296478A/ja active Granted
-
1992
- 1992-06-23 MX MX9203180A patent/MX9203180A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL58828A (en) | 1983-05-15 |
| EP0016255B1 (en) | 1983-09-28 |
| ATE4806T1 (de) | 1983-10-15 |
| YU40768B (en) | 1986-06-30 |
| US4276299A (en) | 1981-06-30 |
| MX9203180A (es) | 1992-07-01 |
| JPS55108862A (en) | 1980-08-21 |
| ZA796464B (en) | 1980-11-26 |
| JPS6321669B2 (es) | 1988-05-09 |
| IT1160387B (it) | 1987-03-11 |
| IT7831198A0 (it) | 1978-12-22 |
| CA1129868A (en) | 1982-08-17 |
| DK150541C (da) | 1987-10-26 |
| IL58828A0 (en) | 1980-02-29 |
| DK539079A (da) | 1980-06-23 |
| EP0016255A2 (en) | 1980-10-01 |
| AU5388879A (en) | 1980-06-26 |
| JPS6323189B2 (es) | 1988-05-16 |
| DE2966234D1 (en) | 1983-11-03 |
| IE49026B1 (en) | 1985-07-10 |
| ES487215A0 (es) | 1980-12-01 |
| IE792460L (en) | 1981-06-22 |
| US4520200A (en) | 1985-05-28 |
| EP0016255A3 (en) | 1980-12-10 |
| GR78203B (es) | 1984-09-26 |
| YU312879A (en) | 1983-02-28 |
| DK150541B (da) | 1987-03-23 |
| AU532551B2 (en) | 1983-10-06 |
| JPS6296478A (ja) | 1987-05-02 |
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