ES544524A0 - Un procedimiento para la preparacion de acidos indol-2-alcanoicos. - Google Patents

Un procedimiento para la preparacion de acidos indol-2-alcanoicos.

Info

Publication number
ES544524A0
ES544524A0 ES544524A ES544524A ES544524A0 ES 544524 A0 ES544524 A0 ES 544524A0 ES 544524 A ES544524 A ES 544524A ES 544524 A ES544524 A ES 544524A ES 544524 A0 ES544524 A0 ES 544524A0
Authority
ES
Spain
Prior art keywords
indol
procedure
preparation
alcanoic acids
alcanoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES544524A
Other languages
English (en)
Other versions
ES8609245A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of ES544524A0 publication Critical patent/ES544524A0/es
Publication of ES8609245A1 publication Critical patent/ES8609245A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES544524A 1984-06-25 1985-06-25 Un procedimiento para la preparacion de acidos indol-2-alcanoicos. Expired ES8609245A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62417384A 1984-06-25 1984-06-25

Publications (2)

Publication Number Publication Date
ES544524A0 true ES544524A0 (es) 1986-09-01
ES8609245A1 ES8609245A1 (es) 1986-09-01

Family

ID=24500964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544524A Expired ES8609245A1 (es) 1984-06-25 1985-06-25 Un procedimiento para la preparacion de acidos indol-2-alcanoicos.

Country Status (12)

Country Link
EP (1) EP0166591B1 (es)
JP (1) JPS6163653A (es)
KR (1) KR860000258A (es)
AU (1) AU4377685A (es)
CA (1) CA1241660A (es)
DE (1) DE3574372D1 (es)
DK (1) DK284485A (es)
ES (1) ES8609245A1 (es)
GR (1) GR851494B (es)
IL (1) IL75586A (es)
PT (1) PT80698B (es)
ZA (1) ZA854762B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543952B1 (fr) * 1982-09-03 1986-02-21 Bristol Myers Co Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique
US5179112A (en) * 1985-04-17 1993-01-12 Ici Americas Inc. Heterocyclic amide derivatives and pharmaceutical use
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
GB8623429D0 (en) * 1985-10-17 1986-11-05 Ici America Inc Carboximide derivatives
IE862737L (en) * 1985-10-17 1987-04-17 Staehler Theo Heterocyclic compounds
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
IL84796A (en) * 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
US5081138A (en) * 1986-12-17 1992-01-14 Merck Frosst Canada, Inc. 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
EP0300675A3 (en) * 1987-07-21 1990-04-11 Merck Frosst Canada Inc. Method for the improvement of cyclosporine therapy
DE3807922A1 (de) * 1988-03-10 1989-09-21 Boehringer Mannheim Gmbh Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
IT1227362B (it) * 1988-11-18 1991-04-08 Istituto Biochimico Italiano Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici
US5093351A (en) * 1989-01-05 1992-03-03 Du Pont Merck Pharmaceutical Company Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors
NZ234883A (en) * 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
US5272145A (en) * 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5204344A (en) * 1989-08-22 1993-04-20 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
CA2079374C (en) * 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
AU3488693A (en) * 1992-02-13 1993-09-03 Merck Frosst Canada Inc. (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
US5374635A (en) * 1993-03-29 1994-12-20 Merck Frosst Canada, Inc. Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
US6069153A (en) * 1998-05-12 2000-05-30 American Home Products Corporation Indenoindoles and benzocarbazoles as estrogenic agents
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
US6159959A (en) * 1999-05-06 2000-12-12 American Home Products Corporation Combined estrogen and antiestrogen therapy
EP1395590B1 (en) * 2001-05-23 2006-09-27 Merck Frosst Canada & Co. Dihydropyrrolo¬1,2-a|indole and tetrahydropyrido¬1,2-a|indole derivatives as prostaglandin d2 receptor antagonists
WO2004039807A1 (en) 2002-10-30 2004-05-13 Merck Frosst Canada & Co. Pyridopyrrolizine and pyridoindolizine derivatives
CN101142185A (zh) 2005-01-19 2008-03-12 比奥里波克斯公司 用于炎症治疗的吲哚
JP5244091B2 (ja) 2006-04-24 2013-07-24 メルク カナダ インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのインドールアミド誘導体
CN113329996B (zh) * 2018-06-25 2023-03-10 博远医药(苏州)有限公司 用于治疗刺猬途径相关病症的化合物和方法
CN109535060B (zh) * 2018-12-20 2022-03-25 苏州麦迪耐斯医药科技有限公司 一种刺猬通路抑制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH455777A (de) * 1965-05-13 1968-05-15 Geigy Ag J R Verfahren zur Herstellung von neuen Indolderivaten
CH454858A (de) * 1965-05-13 1968-04-30 Geigy Ag J R Verfahren zur Herstellung von neuen Indolderivaten

Also Published As

Publication number Publication date
EP0166591B1 (en) 1989-11-23
DE3574372D1 (en) 1989-12-28
PT80698B (en) 1987-03-31
EP0166591A3 (en) 1986-06-25
GR851494B (es) 1985-11-25
AU4377685A (en) 1986-01-02
KR860000258A (ko) 1986-01-27
JPS6163653A (ja) 1986-04-01
DK284485A (da) 1986-02-24
DK284485D0 (da) 1985-06-24
PT80698A (en) 1985-07-01
ZA854762B (en) 1986-02-26
IL75586A (en) 1988-09-30
EP0166591A2 (en) 1986-01-02
ES8609245A1 (es) 1986-09-01
CA1241660A (en) 1988-09-06
IL75586A0 (en) 1985-10-31

Similar Documents

Publication Publication Date Title
ES544524A0 (es) Un procedimiento para la preparacion de acidos indol-2-alcanoicos.
ES544439A0 (es) Procedimiento para la preparacion de acidos a,w -dicarboxi- licos
ES545464A0 (es) Un procedimiento para la preparacion de tetrahidroftalimidas.
ES540705A0 (es) Un procedimiento para la preparacion de 17b-carbamoil-n-monosustituido -o 17b-acil-4-aza-5-alfa-androstien-3-onas.
ES544644A0 (es) Un procedimiento para la preparacion de derivados de carboxamidoadenosina.
ES551249A0 (es) Un procedimiento para la preparacion de peptidilaminodioles.
ES547840A0 (es) Un procedimiento para la preparacion de alquilsulfonamidofe-nilalquilaminas
ES541200A0 (es) Un procedimiento para la preparacion de un derivado de dibenzoilmetano.
ES546236A0 (es) Un procedimiento para la preparacion de derivados de bencimidasol.
ES554983A0 (es) Un procedimiento para la preparacion de silileteres.
ES540609A0 (es) Un procedimiento para la preparacion de pirazolo piridinas.
ES540610A0 (es) Un procedimiento para la preparacion de pirazolopiridinas.
ES544521A0 (es) Un procedimiento para la preparacion de triazolobenzodiazefinas.
ES546872A0 (es) Un procedimiento para la preparacion de aminoalcoxibenzopiranonas.
ES534509A0 (es) Un procedimiento para la preparacion de acidos fenilquinolin-carboxilicos.
ES541781A0 (es) Un procedimiento para la preparacion de nuevos benzotiopenos.
ES550504A0 (es) Un procedimiento para la preparacion de derivados de podofilotoxina.
ES555369A0 (es) Un procedimiento para la preparacion de un polialquenoilisocianato.
ES540200A0 (es) Un procedimiento para la preparacion de acidos 7-amino-3-me-til sustituido-3-defem-4-carboxilicos
ES548595A0 (es) Un procedimiento para la preparacion de composiciones de acidos hidrocarbilsulfonicos.
ES547205A0 (es) Un procedimiento para la preparacion de nuevas quinazolindionas.
ES552402A0 (es) Un procedimiento para la preparacion de 4-amino-2-fenil-quinolinas
ES555723A0 (es) Un procedimiento para la preparacion de tetrahidroimidazoquinazolinonas.
ES545439A0 (es) Un procedimiento para la preparacion de 2-bencil-4-(4-piridil)-tiazoles.
ES542882A0 (es) Un procedimiento para la preparacion de nuevas sulfonilureas.