ES508129A1 - "procedimiento de preparar acido 9-halo-8-hidroxi-4-metil-4-noneoico". - Google Patents

"procedimiento de preparar acido 9-halo-8-hidroxi-4-metil-4-noneoico".

Info

Publication number
ES508129A1
ES508129A1 ES508129A ES508129A ES508129A1 ES 508129 A1 ES508129 A1 ES 508129A1 ES 508129 A ES508129 A ES 508129A ES 508129 A ES508129 A ES 508129A ES 508129 A1 ES508129 A1 ES 508129A1
Authority
ES
Spain
Prior art keywords
hydroxy
methyl
halo
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508129A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55179403A external-priority patent/JPS57102829A/ja
Priority claimed from JP55179404A external-priority patent/JPS57102880A/ja
Priority claimed from JP55180253A external-priority patent/JPS57102838A/ja
Priority claimed from JP55181697A external-priority patent/JPS57106633A/ja
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of ES508129A1 publication Critical patent/ES508129A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/42—Halogenated unsaturated alcohols acyclic
    • C07C33/423—Halogenated unsaturated alcohols acyclic containing only double bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

Procedimiento de preparar ácido 9-halo-8-hidroxi-4-metil-4-nonenoico y sus derivados , de la fórmula **fórmula** en que X es un átomo de halógeno , Y es hidrógeno o un grupo protector de hidroxi y R es hidrógeno o un alquilo inferior, caracterizado porque comprende hacer reaccionar un haluro de prenilo de la fórmula **fórmula** en que Z es un átomo de halógeno, con magnesio para dar un haluro de prenilmagnesio, hacer reaccionar entonces el compuesto resultante con una epihalohidrina de la fórmula **fórmula** en que X es como se ha definido anteriormente, y, si se desea, proteger el grupo hidroxilo del producto con un agente protector para dar un 1-halo-6-metil-5-hepten-2-ol o su derivado de la fórmula: **fórmula** en que X es Y son como se ha definido anteriormente, epoxidar entonces el compuesto resultante para dar un 1-halo-5-6-epoxi-6-metil-2-heptano o su derivado de la fórmula: **fórmula** en que X e Y son como se ha definido anteriormente, someter el compuesto epoxi resultante a redisposición para dar un 1-halo-5-hidroxi-6-meline-2-heptanol o su derivado de la fórmula **fórmula** en que X e Y son como se ha definido anteriormente, hacer reaccionar el producto redispuesto con un éster de ácido ortoacético de la fórmula : CH3C(OR'')3 en que R'' es un alquilo inferior, en presencia de un ácido débil, a lo que sigue hidrólisis, para dar el deseado ácido 9-halo-8-hidroxi-4-metil-4-nonenoico o su derivado
ES508129A 1980-12-18 1981-12-18 "procedimiento de preparar acido 9-halo-8-hidroxi-4-metil-4-noneoico". Expired ES508129A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP55179403A JPS57102829A (en) 1980-12-18 1980-12-18 1-halogeno-6-methyl-5-hepten-2-ol, its derivative, and their preparation
JP55179404A JPS57102880A (en) 1980-12-18 1980-12-18 1-halogeno-5,6-epoxy-6-methyl-2-heptanol, its derivative and preparation thereof
JP55180253A JPS57102838A (en) 1980-12-19 1980-12-19 9-halogeno-8-hydroxy-4-methyl-4-nonenoic acid, its derivative and their preparation
JP55181697A JPS57106633A (en) 1980-12-22 1980-12-22 1-halogeno-5-hydroxy-6-methylene-2-heptanol, its derivative and their preparation

Publications (1)

Publication Number Publication Date
ES508129A1 true ES508129A1 (es) 1982-11-01

Family

ID=27474887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES508129A Expired ES508129A1 (es) 1980-12-18 1981-12-18 "procedimiento de preparar acido 9-halo-8-hidroxi-4-metil-4-noneoico".

Country Status (7)

Country Link
EP (1) EP0054909A3 (es)
AU (1) AU7792481A (es)
DK (1) DK554681A (es)
ES (1) ES508129A1 (es)
FI (1) FI814008L (es)
IL (1) IL64561A0 (es)
NO (1) NO814333L (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317624A (en) * 1969-09-22 1973-05-23 Zoecon Corp Hydroxy alkenoic acids derivatives thereof and their use in the control of insects
CH564303A5 (es) * 1971-01-20 1975-07-31 Hoffmann La Roche

Also Published As

Publication number Publication date
FI814008L (fi) 1982-06-19
AU7792481A (en) 1982-06-24
EP0054909A2 (en) 1982-06-30
DK554681A (da) 1982-06-19
IL64561A0 (en) 1982-03-31
NO814333L (no) 1982-06-21
EP0054909A3 (en) 1982-09-01

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