ES485785A1 - Procedimiento para la obtencion de ortoesteres de hidrocor- tisona - Google Patents

Procedimiento para la obtencion de ortoesteres de hidrocor- tisona

Info

Publication number
ES485785A1
ES485785A1 ES485785A ES485785A ES485785A1 ES 485785 A1 ES485785 A1 ES 485785A1 ES 485785 A ES485785 A ES 485785A ES 485785 A ES485785 A ES 485785A ES 485785 A1 ES485785 A1 ES 485785A1
Authority
ES
Spain
Prior art keywords
hydrocortisone
preparation
pharmaceutical compositions
compositions containing
ortho ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485785A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES485785A1 publication Critical patent/ES485785A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a nuevos ortoésteres de hidrocortisona de fórmula general I **(Fórmula)** en la que R1 y R2 significan respectivamente H o CH3 y n significa 1 ó 2. La invención tiene por objeto encontrar nuevos compuestos con propiedades valiosas, en particular aquellos que puedan emplearse para la preparación de medicamentos. Se ha encontrado que los compuestos de fórmula I poseen valiosas propiedades farmacológicas junto a una buena tolerancia. En particular manifiestan actividad antiflogística que puede considerarse basada por ejemplo en un componente de actividad antiproliferativa, un componente de actividad antiexudativa, un componente de actividad timolítica, y un componente de actividad influenciadora del ACTH.
ES485785A 1978-11-09 1979-11-07 Procedimiento para la obtencion de ortoesteres de hidrocor- tisona Expired ES485785A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782848584 DE2848584A1 (de) 1978-11-09 1978-11-09 Hydrocortison-orthoester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES485785A1 true ES485785A1 (es) 1980-05-16

Family

ID=6054216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485785A Expired ES485785A1 (es) 1978-11-09 1979-11-07 Procedimiento para la obtencion de ortoesteres de hidrocor- tisona

Country Status (11)

Country Link
US (1) US4264584A (es)
EP (1) EP0011134B1 (es)
JP (1) JPS5569600A (es)
AT (1) ATE971T1 (es)
AU (1) AU527561B2 (es)
CA (1) CA1146532A (es)
DE (2) DE2848584A1 (es)
ES (1) ES485785A1 (es)
HU (1) HU180875B (es)
IL (1) IL58641A (es)
ZA (1) ZA796007B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3516298A1 (de) * 1985-05-07 1986-11-13 Sartorius Gmbh Verfahren zur ansteuerung einer fluessigkristallanzeige mit funktionsfehler-erkennbarkeit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147249A (en) * 1961-06-13 1964-09-01 Vismara Francesco Spa 17alpha, 21-substituted methylenedioxy steroids and methods therefor
US3716529A (en) * 1970-05-14 1973-02-13 Syntex Corp Novel c-16,17 spiro-orthoester steroids and preparation
US3798217A (en) * 1970-05-14 1974-03-19 Syntex Corp Novel c-16,17 spiro-orthoester steroids and preparation

Also Published As

Publication number Publication date
HU180875B (en) 1983-04-29
ZA796007B (en) 1980-11-26
CA1146532A (en) 1983-05-17
US4264584A (en) 1981-04-28
EP0011134A1 (de) 1980-05-28
EP0011134B1 (de) 1982-05-05
DE2962723D1 (en) 1982-06-24
ATE971T1 (de) 1982-05-15
IL58641A0 (en) 1980-02-29
AU5261479A (en) 1980-05-15
DE2848584A1 (de) 1980-05-22
AU527561B2 (en) 1983-03-10
IL58641A (en) 1983-07-31
JPS5569600A (en) 1980-05-26

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