ES484101A1 - Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno - Google Patents

Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno

Info

Publication number
ES484101A1
ES484101A1 ES484101A ES484101A ES484101A1 ES 484101 A1 ES484101 A1 ES 484101A1 ES 484101 A ES484101 A ES 484101A ES 484101 A ES484101 A ES 484101A ES 484101 A1 ES484101 A1 ES 484101A1
Authority
ES
Spain
Prior art keywords
preparation
methods
inflammatory agents
corticosteroid anti
corticosteroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES484101A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES484101A1 publication Critical patent/ES484101A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la preparación de corticosteroides derivados de ciclopentanofenantreno de la fórmula general **(Fórmula)** y se elige del grupo de metilo, halometilo y el radical -CH2OC(O)R en donde R es alquilo de C2 a C6 lineal o ramificado; y A es un doble enlace.
ES484101A 1978-04-05 1979-09-01 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno Expired ES484101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,631 US4181720A (en) 1978-04-05 1978-04-05 Corticosteroid antiinflammatory agents

Publications (1)

Publication Number Publication Date
ES484101A1 true ES484101A1 (es) 1980-04-16

Family

ID=25401834

Family Applications (3)

Application Number Title Priority Date Filing Date
ES479268A Expired ES479268A1 (es) 1978-04-05 1979-04-04 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno.
ES484100A Expired ES484100A1 (es) 1978-04-05 1979-09-01 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno
ES484101A Expired ES484101A1 (es) 1978-04-05 1979-09-01 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES479268A Expired ES479268A1 (es) 1978-04-05 1979-04-04 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno.
ES484100A Expired ES484100A1 (es) 1978-04-05 1979-09-01 Un procedimiento para la preparacion de corticosteroides de-rivados de ciclopentanofenantreno

Country Status (16)

Country Link
US (1) US4181720A (es)
EP (1) EP0004765B1 (es)
JP (1) JPS54132563A (es)
AU (1) AU4558479A (es)
DE (1) DE2961648D1 (es)
DK (1) DK136679A (es)
ES (3) ES479268A1 (es)
FI (1) FI791086A7 (es)
GR (1) GR71692B (es)
IL (1) IL56973A0 (es)
IT (1) IT1165656B (es)
NO (1) NO791142L (es)
PL (1) PL118660B1 (es)
PT (1) PT69406A (es)
SU (1) SU942601A3 (es)
ZA (1) ZA791634B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116023425A (zh) * 2023-03-28 2023-04-28 南京师范大学 曲安西龙衍生物及其医药用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446177A (en) * 1984-12-28 1995-08-29 Alcon Laboratories, Inc. Anti-inflammatory compounds for ophthalmic use
DK0650496T3 (da) * 1990-11-13 1999-06-14 Alcon Lab Inc Anti-inflammatoriske forbindelser til oftalmisk anvendelse
FR2692267B1 (fr) * 1992-06-11 1995-05-19 Roussel Uclaf Nouveau procédé de préparation de composés stéroïdes 20-céto 21alpha-hydroxy et intermédiaires.
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031375A (en) * 1960-01-22 1962-04-24 Pfizer & Co C 17 beta-(halo-hydroxy-propanoyl)-pregnene derivatives
US3093665A (en) * 1960-01-22 1963-06-11 Pfizer & Co C 17beta-pyruvoyl-substituted pregnene derivatives
US3234095A (en) * 1963-06-19 1966-02-08 Pfizer & Co C 21-methyl and 21-hydroxymethyl steroid compounds
AU496759B2 (en) * 1972-12-27 1978-10-26 Schering Aktiengesellschaft New pregnan-21-oic derivatives
US4011315A (en) * 1975-07-07 1977-03-08 Syntex (U.S.A.) Inc. 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116023425A (zh) * 2023-03-28 2023-04-28 南京师范大学 曲安西龙衍生物及其医药用途

Also Published As

Publication number Publication date
AU4558479A (en) 1979-10-18
PL118660B1 (en) 1981-10-31
PT69406A (en) 1979-04-01
DE2961648D1 (en) 1982-02-18
EP0004765A2 (en) 1979-10-17
IL56973A0 (en) 1979-05-31
EP0004765A3 (en) 1979-10-31
FI791086A7 (fi) 1981-01-01
EP0004765B1 (en) 1981-12-30
DK136679A (da) 1979-10-06
ZA791634B (en) 1980-11-26
ES479268A1 (es) 1979-12-01
GR71692B (es) 1983-06-21
ES484100A1 (es) 1980-04-16
US4181720A (en) 1980-01-01
NO791142L (no) 1979-10-08
IT7967710A0 (it) 1979-04-04
IT1165656B (it) 1987-04-22
JPS54132563A (en) 1979-10-15
SU942601A3 (ru) 1982-07-07
PL214673A1 (pl) 1979-12-17

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