ES480779A1 - Un procedimiento para la preparacion de derivados de 1-hidroxial-canamin-piramo (3,4-b)-indol. - Google Patents

Un procedimiento para la preparacion de derivados de 1-hidroxial-canamin-piramo (3,4-b)-indol.

Info

Publication number
ES480779A1
ES480779A1 ES480779A ES480779A ES480779A1 ES 480779 A1 ES480779 A1 ES 480779A1 ES 480779 A ES480779 A ES 480779A ES 480779 A ES480779 A ES 480779A ES 480779 A1 ES480779 A1 ES 480779A1
Authority
ES
Spain
Prior art keywords
derivatives
preparation
indole derivatives
thiopyrano
pyrano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480779A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of ES480779A1 publication Critical patent/ES480779A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevos derivados de piranoindol, a un procedimiento y a los intermediarios para la preparación de derivados, a métodos para utilizar los derivados y a composiciones y sales de los derivados aceptables en farmacia. Más concretamente se refiere a nuevos derivados de 1,3,4,9-tetrahidropirano(3,4-b)-indol o derivados de 1,3,4,9-tetrahidrotiopiran(3,4-b)-indol que tiene n una hidroxialcanamina o alcoxialcanamina inferior y un grupo de alquilo inferior en posición 1. Estos derivados son útiles como agentes diuréticos en un mamífero a dosis que no producen efectos secundarios indeseables. La combinación de estos atributos hace que los derivados de 1,3,4,9-tetrahidro(tio)piranol(3,4-b)-indol de este invento sean terapéuticamente útiles.
ES480779A 1978-05-08 1979-05-07 Un procedimiento para la preparacion de derivados de 1-hidroxial-canamin-piramo (3,4-b)-indol. Expired ES480779A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/904,081 US4179503A (en) 1978-05-08 1978-05-08 1-Hydroxyalkanamine pyrano[3,4-b]indole derivatives

Publications (1)

Publication Number Publication Date
ES480779A1 true ES480779A1 (es) 1980-08-16

Family

ID=25418510

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480779A Expired ES480779A1 (es) 1978-05-08 1979-05-07 Un procedimiento para la preparacion de derivados de 1-hidroxial-canamin-piramo (3,4-b)-indol.

Country Status (11)

Country Link
US (1) US4179503A (es)
EP (1) EP0005365B1 (es)
JP (1) JPS55500245A (es)
AU (1) AU4642279A (es)
CA (1) CA1132138A (es)
DE (1) DE2961746D1 (es)
DK (1) DK6780A (es)
ES (1) ES480779A1 (es)
PH (1) PH15062A (es)
WO (1) WO1979001037A1 (es)
ZA (1) ZA791804B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544757A (en) * 1984-02-16 1985-10-01 American Home Products Corporation Process for the resolution of pyrano[3,4-b]indole-1-acetic acids
US6545034B1 (en) * 1999-07-23 2003-04-08 The Regents Of The University Of California Use of etodolac for the treatment of chronic lymphocytic leukemia
US7105560B1 (en) 1999-07-23 2006-09-12 The Regents Of The University Of California Use of etodolac in the treatment of multiple myeloma
US7361680B2 (en) * 1999-07-23 2008-04-22 The Regents Of The University Of California Indole compounds useful for the treatment of cancer
US7129262B2 (en) * 1999-07-23 2006-10-31 The Regents Of The University Of California Indole compounds useful for the treatment of cancer
US7151100B1 (en) * 1999-07-23 2006-12-19 The Regents Of The University Of California Indole compounds useful for the treatment of cancer
US20040152672A1 (en) * 2000-08-09 2004-08-05 Carson Dennis A. Indole compounds useful for the treatment of cancer
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
TW200400818A (en) 2002-05-21 2004-01-16 Wyeth Corp Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
US7211599B2 (en) * 2002-09-19 2007-05-01 The Regents Of The University Of California Use of etodolac to treat hyperplasia
US7446122B2 (en) * 2003-10-02 2008-11-04 Cephalon, Inc. Substituted indole derivatives
US20060058532A1 (en) * 2004-09-10 2006-03-16 Warren Chew Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives
EP1683521A1 (en) * 2005-01-21 2006-07-26 Centre National De La Recherche Scientifique (Cnrs) Peptide deformylase inhibitors, their use, and pharmaceutical compositions containing the same
JP6250280B2 (ja) * 2009-03-26 2017-12-20 グプタ，アジャイ 腎疾患の治療のための組成物及び方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843681A (en) * 1971-06-01 1974-10-22 American Home Prod 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives
US3880853A (en) * 1972-01-13 1975-04-29 Ayerst Mckenna & Harrison Pyrano-and thiopyranoindole
US3778449A (en) * 1972-10-12 1973-12-11 Ayerst Mckenna & Harrison Indenopyran-and indenothiopyran alkylamines
US3910954A (en) * 1972-10-12 1975-10-07 Ayerst Mckenna & Harrison Indenopyran- and indenothiopyranalkylamines
US4056537A (en) * 1974-09-18 1977-11-01 Ayerst Mckenna And Harrison Ltd. Process for making pyrano- and thiopyranoindole derivatives

Also Published As

Publication number Publication date
AU4642279A (en) 1979-11-15
WO1979001037A1 (en) 1979-11-29
PH15062A (en) 1982-06-03
DE2961746D1 (en) 1982-02-25
JPS55500245A (es) 1980-04-24
CA1132138A (en) 1982-09-21
ZA791804B (en) 1980-11-26
EP0005365A1 (en) 1979-11-14
DK6780A (da) 1980-01-07
US4179503A (en) 1979-12-18
EP0005365B1 (en) 1982-01-06

Similar Documents

Publication Publication Date Title
ES480779A1 (es) Un procedimiento para la preparacion de derivados de 1-hidroxial-canamin-piramo (3,4-b)-indol.
ES479271A1 (es) Un procedimiento para la preparacion de compuestos derivados de acido tioetianico.
MX9203264A (es) Nuevos derivados de la tieno(3,2-c)piridina y composiciones farmaceuticas que los contienen.
ES8705393A1 (es) Un procedimiento para preparar un derivado de pirazol (como divisional de la solicitud de patente de invencion n 543.046, presentada el 10.5.85)
AU538424B2 (en) Piperazino phenylindane
IT1144033B (it) Derivati triciclici e loro sali farmacologicamente attivi e composizioni farmaceutiche che li contengono,nonche' procedimento per la loro preparazione
ES449963A2 (es) Procedimiento de preparacion de derivados piridinicos.
DE3364462D1 (en) Process for the preparation of acemetacin
IT8020667A0 (it) Derivati tetraciclici dell'indolo.
ES484022A1 (es) Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol
ES8604731A1 (es) Un metodo de preparar derivados de 6,11-dihidrodibenz (b,e) oxepina
IT1150024B (it) 4-fenil-4,5,6,7-tetraidropirrolo(2,3-c) piridine,procedimento per la loro fabbricazione,nonche'composizioni farmaceutiche relative
MY101765A (en) Benzopyran derivatives, compositions containing them and processes for their production
ES480562A1 (es) Un procedimiento para la preparacion de un nuevo vincaderi- vado dimero.
JPS523096A (en) Preparation of furo- 3,2-b indoles
JPS5212167A (en) Chroman derivatives
FR2451380A1 (fr) Nouveaux derives du dithiepinno (1,4) (2,3-c) pyrrole, leur preparation et les medicaments qui les contiennent
JPS5225765A (en) Preparation of novel isoindoline derivatives
IT8121299A0 (it) Derivati della vincamina e di alcaloidi indolici correlati adattivita' terapeutica, procedimento per la loro preparazione e composizioni farmaceutiche che licontengono.
JPS51146435A (en) Process for preparing p'-n-alkoxyphenyl p-cyanociannamates
JPS5233648A (en) Preparation of 3',4',-dideoxy-3',4',-didehydro-butyrosine derivatives
JPS51138692A (en) Process for preparing dihydrothieno (3.4-2) imidazoline derivatives
JPS5223069A (en) Preparation of 3-substituted-pyrrole derivatives
JPS5236697A (en) Process for preparation of hexahydro-1h- pyrido(4,3-b)-indole derivati ves
JPS51131895A (en) A process for preparing 2,3,4,4a,5,9b- hexahydro-1h-pyrid(4,3-b)indole derivatives