ES484022A1 - Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol - Google Patents
Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indolInfo
- Publication number
- ES484022A1 ES484022A1 ES484022A ES484022A ES484022A1 ES 484022 A1 ES484022 A1 ES 484022A1 ES 484022 A ES484022 A ES 484022A ES 484022 A ES484022 A ES 484022A ES 484022 A1 ES484022 A1 ES 484022A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- pyrimido
- preparation
- processes
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un procedimiento para la preparación de derivados de pirimido (1,6-a)indol, de la fórmula general I **(Fórmula)** en donde R1 es hidrógeno, alquilo inferior, alcoxilo inferior, benciloxilo, alcanoiloxilo inferior, halo, nitro o trifluorometilo; R2 es hidrógeno, alquilo inferior, ciclo-alquilo(inferior), fenil-alquilo(inferior), fenilo o un radical de la fórmula - (CH2)h-NR6R7 donde h es un número entero comprendido entre 0 y 6, R6 es alquilo inferior y R7 es hidrógeno o alquilo inferior o R6 y R7 juntos forman una cadena de la fórmula -(CH2)k- en donde k es un número entero comprendido entre 4 y 7; R3 es hidrógeno, alquilo inferior, bencilo o fenilo; R4 es alquilo inferior; o R3 y R4 juntos forman una cadena de la fórmula -(CH2)m- en donde m es un número entero comprendido entre 5 y 7; y R5 es bromo, cloro, hidroxilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/941,816 US4307234A (en) | 1978-09-11 | 1978-09-11 | Pyrimido[1,6-a]indole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES484022A1 true ES484022A1 (es) | 1980-04-16 |
Family
ID=25477108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES484022A Expired ES484022A1 (es) | 1978-09-11 | 1979-09-10 | Un procedimiento para la preparacion de derivados de pirimi-do (1-6-a)indol |
Country Status (5)
Country | Link |
---|---|
US (1) | US4307234A (es) |
EP (1) | EP0008950A3 (es) |
CA (1) | CA1128935A (es) |
ES (1) | ES484022A1 (es) |
WO (1) | WO1980000537A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE13673T1 (de) * | 1980-03-04 | 1985-06-15 | Ciba Geigy Ag | Neue amidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung. |
US4444768A (en) * | 1980-03-04 | 1984-04-24 | Ciba-Geigy Corporation | Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them |
ZA824382B (en) * | 1981-07-07 | 1984-02-29 | Wyeth John & Brother Ltd | Anti-obesity agents |
EP0072346B1 (de) * | 1981-08-03 | 1986-04-09 | Ciba-Geigy Ag | Weitere neue Amidine, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und ihre Verwendung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2187813A (en) * | 1936-05-30 | 1940-01-23 | Gen Aniline Works Inc | Vat dyestuff of the phthaloyl quinazoline series |
US3410851A (en) * | 1963-09-03 | 1968-11-12 | Miles Lab | Derivatives of flavone |
US3635966A (en) * | 1969-10-22 | 1972-01-18 | Robins Co Inc A H | 6-substituted-indolo(1 2-c)quinazolines |
US3649626A (en) * | 1970-04-27 | 1972-03-14 | Warner Lambert Co | Fused ring systems containing (1 3)oxazine |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
SU481613A1 (ru) * | 1973-04-27 | 1975-08-25 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.Орджоникидзе | Способ получени замещенных индоло /1,2-с/ хиназолинов |
SU539885A1 (ru) * | 1975-07-18 | 1976-12-25 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Имени С.Орджоникидзе | Способ получени производных 12-ацетиламиноиндоло /1,2-с/ хиназолинов |
-
1978
- 1978-09-11 US US05/941,816 patent/US4307234A/en not_active Expired - Lifetime
-
1979
- 1979-08-10 CA CA333,582A patent/CA1128935A/en not_active Expired
- 1979-08-27 WO PCT/US1979/000656 patent/WO1980000537A1/en unknown
- 1979-09-06 EP EP79301836A patent/EP0008950A3/en not_active Withdrawn
- 1979-09-10 ES ES484022A patent/ES484022A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0008950A3 (en) | 1980-06-11 |
WO1980000537A1 (en) | 1980-04-03 |
EP0008950A2 (en) | 1980-03-19 |
CA1128935A (en) | 1982-08-03 |
US4307234A (en) | 1981-12-22 |
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