ES480648A1 - Procedimiento de preparacion de un derivado de tetrahidro- isoquinoleina. - Google Patents

Procedimiento de preparacion de un derivado de tetrahidro- isoquinoleina.

Info

Publication number
ES480648A1
ES480648A1 ES480648A ES480648A ES480648A1 ES 480648 A1 ES480648 A1 ES 480648A1 ES 480648 A ES480648 A ES 480648A ES 480648 A ES480648 A ES 480648A ES 480648 A1 ES480648 A1 ES 480648A1
Authority
ES
Spain
Prior art keywords
tetrahydro
tetrahydroisoquinoline
isoquinoline derivatives
chlorobenzoyl
chlorobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480648A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES480648A1 publication Critical patent/ES480648A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedimiento de preparación de un derivado de tetrahidro-isoquinoleína, que responde a la fórmula **(Fórmula-01)** así como de sus sales de adición con ácidos farmacéuticamente aceptable, procedimiento caracterizado por el hecho de que se somete a una reacción de reducción la amida de la fórmula **(Fórmula-02)** con ayuda de hidruro de boro en tetrahidrofurano bajo nitrógeno, en frío; y, si se desea, se transforma el compuesto obtenido de fórmula I en sus sales según cualquier procedimiento apropiado.
ES480648A 1978-05-18 1979-05-17 Procedimiento de preparacion de un derivado de tetrahidro- isoquinoleina. Expired ES480648A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7814804A FR2426046A1 (fr) 1978-05-18 1978-05-18 Derive de tetrahydro-isoquinoleine, sa preparation et son application en therapeutique

Publications (1)

Publication Number Publication Date
ES480648A1 true ES480648A1 (es) 1980-07-01

Family

ID=9208413

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480648A Expired ES480648A1 (es) 1978-05-18 1979-05-17 Procedimiento de preparacion de un derivado de tetrahidro- isoquinoleina.

Country Status (15)

Country Link
US (1) US4261998A (es)
JP (1) JPS54151986A (es)
AU (1) AU4704979A (es)
BE (1) BE876372A (es)
DE (1) DE2919553A1 (es)
ES (1) ES480648A1 (es)
FR (1) FR2426046A1 (es)
GB (1) GB2021109B (es)
IL (1) IL57333A0 (es)
IT (1) IT1114249B (es)
LU (1) LU81285A1 (es)
NL (1) NL7903881A (es)
NZ (1) NZ190491A (es)
PT (1) PT69626A (es)
ZA (1) ZA792431B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
EP0306375A1 (fr) * 1987-08-07 1989-03-08 Synthelabo Dérivés de[(pipéridinyl-4)méthyl]-2 tétrahydro-1,2,3,4 isoquinoléine, leur préparation et leur application en thérapeutique
IL89156A (en) * 1988-07-12 1993-05-13 Synthelabo Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics
US4963563A (en) * 1989-10-13 1990-10-16 Abbott Laboratories 6-substituted-1,2,3,4-tetrahydroisoquinolines
WO1999024022A2 (en) * 1997-11-10 1999-05-20 F. Hoffmann-La Roche Ag Isoquinoline derivatives for treating disorders associated with 5ht7 receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250828B (de) * 1962-10-10 1967-09-28 Chinoin Gyogyszer es Vegyeszeti Termekek Gyära R.T., Budapest Verfahren zur Herstellung des spasmolytisch wirksamen 6,7,3',4' - Tetraäthoxy -l-benzyliden-1,2,3,4tetrahydroisochinolins und seiner Salze
US3562280A (en) * 1967-08-30 1971-02-09 Hoffmann La Roche Substituted 1,2,3,4-tetrahydroisoquinolines
FR2054483A1 (en) * 1969-07-11 1971-04-23 Anvar Sympatholytic tsoquinoline derivs

Also Published As

Publication number Publication date
IT7922747A0 (it) 1979-05-17
FR2426046A1 (fr) 1979-12-14
IT1114249B (it) 1986-01-27
GB2021109A (en) 1979-11-28
NZ190491A (en) 1980-11-28
LU81285A1 (fr) 1980-12-16
DE2919553A1 (de) 1979-11-22
IL57333A0 (en) 1979-09-30
ZA792431B (en) 1980-06-25
FR2426046B1 (es) 1980-10-03
JPS54151986A (en) 1979-11-29
NL7903881A (nl) 1979-11-20
AU4704979A (en) 1979-11-29
US4261998A (en) 1981-04-14
PT69626A (fr) 1979-06-01
GB2021109B (en) 1982-07-28
BE876372A (fr) 1979-11-19

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