FR2054483A1 - Sympatholytic tsoquinoline derivs - Google Patents

Sympatholytic tsoquinoline derivs

Info

Publication number
FR2054483A1
FR2054483A1 FR6923765A FR6923765A FR2054483A1 FR 2054483 A1 FR2054483 A1 FR 2054483A1 FR 6923765 A FR6923765 A FR 6923765A FR 6923765 A FR6923765 A FR 6923765A FR 2054483 A1 FR2054483 A1 FR 2054483A1
Authority
FR
France
Prior art keywords
sympatholytic
tsoquinoline
derivs
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6923765A
Other languages
French (fr)
Other versions
FR2054483B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR6923765A priority Critical patent/FR2054483A1/en
Priority to CH1024470A priority patent/CH553184A/en
Priority to DK359870A priority patent/DK127815B/en
Priority to LU61296D priority patent/LU61296A1/xx
Priority to BE753290D priority patent/BE753290A/en
Priority to CA087,850A priority patent/CA944353A/en
Priority to DE19702034587 priority patent/DE2034587A1/en
Priority to ES382228A priority patent/ES382228A1/en
Priority to NL7010327A priority patent/NL7010327A/xx
Publication of FR2054483A1 publication Critical patent/FR2054483A1/en
Application granted granted Critical
Publication of FR2054483B1 publication Critical patent/FR2054483B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Compounds of formula: where A is a C1-4 polymethylene chain, R1 includes hydrogen, halogen, alkyl in positions 5, 6, 7 or 8 of the isoquinoline nuceus, R3 includes hydrogen, halogen, nitro, amino, alkyl, e.g. 6,7-dimethoxy-2-benzyl-1,2,3,4-tetra-hydroisoquinoline are active pharmaceuticals with partic. good sympatholytic action.
FR6923765A 1969-07-11 1969-07-11 Sympatholytic tsoquinoline derivs Granted FR2054483A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR6923765A FR2054483A1 (en) 1969-07-11 1969-07-11 Sympatholytic tsoquinoline derivs
CH1024470A CH553184A (en) 1969-07-11 1970-07-07 PROCESS FOR MANUFACTURING ISOQUINOLEINE DERIVATIVES FOR THE MANUFACTURE OF NEW MEDICINES.
LU61296D LU61296A1 (en) 1969-07-11 1970-07-09
DK359870A DK127815B (en) 1969-07-11 1970-07-09 Analogous process for the preparation of substituted isoquinolines or the hydrobromide or methyl iodide thereof.
BE753290D BE753290A (en) 1969-07-11 1970-07-10 NEW MEDICINES, IN PARTICULAR SYMPATHICOLYTICS, BASED ON ISOQUINOLEIN DERIVATIVES, AND NEW ISOQUINOLEIN SUBSTITUTES
CA087,850A CA944353A (en) 1969-07-11 1970-07-10 Methods of manufacturing isoquinoline derivatives for the production of new substituted isoquinolines
DE19702034587 DE2034587A1 (en) 1969-07-11 1970-07-11 New, especially sympatholytic, pharmaceutical compositions based on isoquinolines and new substituted isoquinolines
ES382228A ES382228A1 (en) 1969-07-11 1970-07-11 Manufacturing method of substitute isoquinoleins. (Machine-translation by Google Translate, not legally binding)
NL7010327A NL7010327A (en) 1969-07-11 1970-07-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6923765A FR2054483A1 (en) 1969-07-11 1969-07-11 Sympatholytic tsoquinoline derivs

Publications (2)

Publication Number Publication Date
FR2054483A1 true FR2054483A1 (en) 1971-04-23
FR2054483B1 FR2054483B1 (en) 1973-06-08

Family

ID=9037354

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6923765A Granted FR2054483A1 (en) 1969-07-11 1969-07-11 Sympatholytic tsoquinoline derivs

Country Status (9)

Country Link
BE (1) BE753290A (en)
CA (1) CA944353A (en)
CH (1) CH553184A (en)
DE (1) DE2034587A1 (en)
DK (1) DK127815B (en)
ES (1) ES382228A1 (en)
FR (1) FR2054483A1 (en)
LU (1) LU61296A1 (en)
NL (1) NL7010327A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261998A (en) * 1978-05-18 1981-04-14 Synthelabo Tetrahydro-isoquinoline derivatives
EP0051190A2 (en) * 1980-10-17 1982-05-12 Pennwalt Corporation N-(amino(or hydroxy) phenethyl)-1,2,3,4-tetrahydroisoquinolines, precursors thereof, and methods of preparation
EP0236251A2 (en) * 1986-03-05 1987-09-09 Universite Louis Pasteur (Strasbourg I) 2-(2-aminobenzyl)-1,2,3,4-tetrahydroisoquinolines, processes for obtaining them and pharmaceutical compositions containing them
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
WO1998051672A2 (en) * 1997-08-12 1998-11-19 Oy Juvantia Pharma Ltd. A method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100812843B1 (en) * 2005-06-01 2008-03-11 한화석유화학 주식회사 3,4-dihydroisoquinolinium salt derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US223373A (en) * 1880-01-06 Spring-propelled carriage
BE724638A (en) * 1967-11-30 1969-05-29

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US223373A (en) * 1880-01-06 Spring-propelled carriage
BE724638A (en) * 1967-11-30 1969-05-29

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261998A (en) * 1978-05-18 1981-04-14 Synthelabo Tetrahydro-isoquinoline derivatives
EP0051190A2 (en) * 1980-10-17 1982-05-12 Pennwalt Corporation N-(amino(or hydroxy) phenethyl)-1,2,3,4-tetrahydroisoquinolines, precursors thereof, and methods of preparation
EP0051190A3 (en) * 1980-10-17 1982-06-23 Pennwalt Corporation N-(amino(or hydroxy) phenethyl)-1,2,3,4-tetrahydroisoquinolines, precursors thereof, and methods of preparation
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics
EP0236251A2 (en) * 1986-03-05 1987-09-09 Universite Louis Pasteur (Strasbourg I) 2-(2-aminobenzyl)-1,2,3,4-tetrahydroisoquinolines, processes for obtaining them and pharmaceutical compositions containing them
WO1987005295A1 (en) * 1986-03-05 1987-09-11 Universite Louis Pasteur Derivatives of (nitro-2 or amino-2 benzyl)-2 tetrahydro-1,2,3,4 isoquinoleines, as well as methods for obtaining them and pharmaceutical compositions containing them
FR2595356A1 (en) * 1986-03-05 1987-09-11 Pasteur Strasbourg Universite NITRO OR AMINOBENZYLTETRAHYDROISOQUINOLINE DERIVATIVES, PROCESSES FOR OBTAINING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, PHARMACOLOGICAL PROPERTIES AND APPLICATIONS
EP0236251A3 (en) * 1986-03-05 1988-03-02 Universite Louis Pasteur (Strasbourg I) 2-(2-aminobenzyl)-1,2,3,4-tetrahydroisoquinolines, processes for obtaining them and pharmaceutical compositions containing them
US4925943A (en) * 1986-03-05 1990-05-15 Isabelle Kanmacher 2-(2-aminobenzyl or 2-nitrobenzyl)-1,2,3,4-tetrahydroisoquinoline derivatives
WO1998051672A2 (en) * 1997-08-12 1998-11-19 Oy Juvantia Pharma Ltd. A method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives
WO1998051672A3 (en) * 1997-08-12 1999-03-11 Juvantia Pharma Ltd Oy A method for the preparation of tertiary amines, a compound useful therefor and alpha-2-receptor active tetrahydroisoquinoline derivatives

Also Published As

Publication number Publication date
DE2034587A1 (en) 1971-02-11
FR2054483B1 (en) 1973-06-08
CH553184A (en) 1974-08-30
CA944353A (en) 1974-03-26
LU61296A1 (en) 1970-09-10
DK127815B (en) 1974-01-14
BE753290A (en) 1971-01-11
NL7010327A (en) 1971-01-13
ES382228A1 (en) 1972-12-01

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Legal Events

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