ES480565A1 - Un procedimiento para la preparacion de nuevos derivados de 1,2 y 1,3 (di-0-n-alquil)glicerilo. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 1,2 y 1,3 (di-0-n-alquil)glicerilo.

Info

Publication number
ES480565A1
ES480565A1 ES79480565A ES480565A ES480565A1 ES 480565 A1 ES480565 A1 ES 480565A1 ES 79480565 A ES79480565 A ES 79480565A ES 480565 A ES480565 A ES 480565A ES 480565 A1 ES480565 A1 ES 480565A1
Authority
ES
Spain
Prior art keywords
glycerol derivatives
alkyl glycerol
immune stimulants
alkyl
stimulants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES79480565A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES480565A1 publication Critical patent/ES480565A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Nuevos derivados de la invención de 1,2- y 1,3-(di-0-n-alquil) glicerol y sus sales de adición de ácidos farmacéuticamente aceptables que son útiles como estimulantes no específicos de la inmunidad medida celularmente.
ES79480565A 1978-05-15 1979-05-14 Un procedimiento para la preparacion de nuevos derivados de 1,2 y 1,3 (di-0-n-alquil)glicerilo. Expired ES480565A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/906,260 US4173641A (en) 1978-05-15 1978-05-15 Di-O-n-alkyl glycerol derivatives as immune stimulants

Publications (1)

Publication Number Publication Date
ES480565A1 true ES480565A1 (es) 1980-08-16

Family

ID=25422164

Family Applications (1)

Application Number Title Priority Date Filing Date
ES79480565A Expired ES480565A1 (es) 1978-05-15 1979-05-14 Un procedimiento para la preparacion de nuevos derivados de 1,2 y 1,3 (di-0-n-alquil)glicerilo.

Country Status (38)

Country Link
US (1) US4173641A (es)
JP (2) JPS5924974B2 (es)
AR (1) AR221724A1 (es)
AT (1) AT372678B (es)
AU (1) AU513771B2 (es)
BE (1) BE876229A (es)
CA (1) CA1105935A (es)
CH (1) CH639939A5 (es)
DD (1) DD144540A5 (es)
DE (1) DE2919514C2 (es)
DK (1) DK149946C (es)
EG (1) EG15252A (es)
ES (1) ES480565A1 (es)
FI (1) FI69450C (es)
FR (1) FR2426039A1 (es)
GB (1) GB2021580B (es)
GR (1) GR72419B (es)
GT (1) GT197957869A (es)
HK (1) HK13584A (es)
HU (1) HU180283B (es)
IE (1) IE48229B1 (es)
IL (1) IL57268A (es)
IN (1) IN150574B (es)
IT (1) IT1115217B (es)
KE (1) KE3354A (es)
LU (1) LU81253A1 (es)
MY (1) MY8500096A (es)
NL (1) NL175524C (es)
NO (1) NO151285C (es)
NZ (1) NZ190444A (es)
PH (1) PH15256A (es)
PL (1) PL123910B1 (es)
PT (1) PT69607A (es)
SE (1) SE429966B (es)
SG (1) SG65483G (es)
SU (1) SU1122220A3 (es)
YU (1) YU41156B (es)
ZA (1) ZA792306B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255426A (en) * 1979-07-09 1981-03-10 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
US4312877A (en) * 1979-07-09 1982-01-26 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
US4395394A (en) * 1979-10-26 1983-07-26 Pfizer Inc. Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
US4310550A (en) * 1979-10-26 1982-01-12 Pfizer Inc. Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
JPS60105650A (ja) * 1983-11-14 1985-06-11 Ono Pharmaceut Co Ltd グリセリン誘導体、その製造方法及びその誘導体を含有する薬剤
US4880626A (en) * 1985-01-18 1989-11-14 Mcmichael John Immunotherapeutic methods and compositions for the treatment of diseases of viral origin, including acquired immune deficiency syndrome
JPS62156230A (ja) * 1985-12-27 1987-07-11 Nippon Steel Corp 帯状物の蛇行修正方法
US4842862A (en) * 1986-07-03 1989-06-27 International Minerals & Chemical Corp. Immunostimulating agents
ZA899436B (en) * 1988-12-12 1990-08-29 Ciba Geigy Piperidine derivatives
WO2005077963A1 (fr) * 2004-01-16 2005-08-25 Institut Superieur Agricole De Beauvais DErivEs de saccharides et d'itols possEdant un groupement O-alkyle ou un groupement O-alkyle et un groupement O-n-butanoyle. Applications comme mEdicaments dans les pathologies prolifEratives tumorales ou bEnignes.
BR112012015755B1 (pt) * 2009-12-23 2021-06-22 Novartis Ag Lipídeo furtivo, e composição

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2738351A (en) * 1952-08-02 1956-03-13 Bristol Lab Inc Substituted glycerol ethers
US3432602A (en) * 1967-12-20 1969-03-11 Astra Ab Oral alkyl glycerol ether improvement in radiation,radiomimetic,or cytostatic tumor therapies
US3943173A (en) * 1972-11-22 1976-03-09 Smithkline Corporation 3-Alkylamino- alpha-aminomethyl-4-hydroxybenzyl alcohols
US4012528A (en) * 1974-06-03 1977-03-15 Smithkline Corporation α-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS HAVING β-ADRENERGIC STIMULANT ACTIVITY
US4069223A (en) * 1977-05-02 1978-01-17 G. D. Searle & Co. 4-Aminomethyl-1-(3,3,3-triarylpropyl)-4-arylpiperidine and derivatives thereof
US4166132A (en) * 1977-08-18 1979-08-28 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols

Also Published As

Publication number Publication date
SE7904216L (sv) 1979-11-16
IE790938L (en) 1979-11-15
DK149946C (da) 1987-06-15
SE429966B (sv) 1983-10-10
HU180283B (en) 1983-02-28
IT1115217B (it) 1986-02-03
IT7922664A0 (it) 1979-05-14
NL175524C (nl) 1984-11-16
DK149946B (da) 1986-11-03
LU81253A1 (fr) 1979-12-07
FI69450B (fi) 1985-10-31
GT197957869A (es) 1980-11-04
DE2919514A1 (de) 1979-11-22
KE3354A (en) 1983-12-16
CH639939A5 (fr) 1983-12-15
DD144540A5 (de) 1980-10-22
DE2919514C2 (de) 1982-06-03
NZ190444A (en) 1981-05-29
AT372678B (de) 1983-11-10
FR2426039B1 (es) 1983-12-16
YU41156B (en) 1986-12-31
PT69607A (en) 1979-06-01
NO151285B (no) 1984-12-03
IN150574B (es) 1982-11-13
JPS58131947A (ja) 1983-08-06
ATA356179A (de) 1983-03-15
SG65483G (en) 1984-07-27
IL57268A0 (en) 1979-09-30
NL7903769A (nl) 1979-11-19
IL57268A (en) 1982-05-31
JPS55378A (en) 1980-01-05
MY8500096A (en) 1985-12-31
GR72419B (es) 1983-11-03
GB2021580B (en) 1982-09-08
ZA792306B (en) 1980-05-28
YU109479A (en) 1983-02-28
JPS6139301B2 (es) 1986-09-03
FI791531A (fi) 1979-11-16
FI69450C (fi) 1986-02-10
AU4701679A (en) 1979-11-22
IE48229B1 (en) 1984-11-14
SU1122220A3 (ru) 1984-10-30
JPS5924974B2 (ja) 1984-06-13
AR221724A1 (es) 1981-03-13
FR2426039A1 (fr) 1979-12-14
PL215573A1 (es) 1980-07-01
NO151285C (no) 1985-03-13
HK13584A (en) 1984-02-24
DK102479A (da) 1979-11-16
CA1105935A (en) 1981-07-28
BE876229A (fr) 1979-11-14
PL123910B1 (en) 1982-12-31
US4173641A (en) 1979-11-06
AU513771B2 (en) 1980-12-18
NO791604L (no) 1979-11-16
PH15256A (en) 1982-11-02
EG15252A (en) 1986-09-30
GB2021580A (en) 1979-12-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203