ES478530A1 - Procedimiento para la preparacion de nuevos compuestos ana- logos de prostaciclina. - Google Patents

Procedimiento para la preparacion de nuevos compuestos ana- logos de prostaciclina.

Info

Publication number
ES478530A1
ES478530A1 ES478530A ES478530A ES478530A1 ES 478530 A1 ES478530 A1 ES 478530A1 ES 478530 A ES478530 A ES 478530A ES 478530 A ES478530 A ES 478530A ES 478530 A1 ES478530 A1 ES 478530A1
Authority
ES
Spain
Prior art keywords
medicines
intermediates
preparation
prostacyclin analogs
prostacyclin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478530A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES478530A1 publication Critical patent/ES478530A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos compuestos análogos de prostaciclina de la fórmula I. **(formula)** en que R1 significa hidrógeno o un radical alcohilo de cadena recta o ramificada con uno a seis átomos de carbono, o un radical alifático no saturado de cadena recta o ramificada con tres a seis átomos de carbono, o un radical cicloalifatico con tres a siete átomos de carbono, o un radical aralifático con siete a nueve átomos de carbono, o un ión fisiológicamente compatible, metálico, NH4 o amonio, que se deriva de una amina primaria, secundaria o terciaria, o un ión tetraalcohilamonio, R2 significa un radical alcohilo de cadena recta o ramificada con uno a ocho átomos de carbono, o un radical alifático no saturado de cadena recta o ramificada con tres a ocho átomos de carbono.
ES478530A 1978-03-18 1979-03-12 Procedimiento para la preparacion de nuevos compuestos ana- logos de prostaciclina. Expired ES478530A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782811950 DE2811950A1 (de) 1978-03-18 1978-03-18 Neue analoga von prostacyclin

Publications (1)

Publication Number Publication Date
ES478530A1 true ES478530A1 (es) 1979-11-01

Family

ID=6034863

Family Applications (1)

Application Number Title Priority Date Filing Date
ES478530A Expired ES478530A1 (es) 1978-03-18 1979-03-12 Procedimiento para la preparacion de nuevos compuestos ana- logos de prostaciclina.

Country Status (7)

Country Link
EP (1) EP0004335A3 (es)
JP (1) JPS54130558A (es)
AU (1) AU4518279A (es)
DE (1) DE2811950A1 (es)
ES (1) ES478530A1 (es)
IL (1) IL56892A0 (es)
ZA (1) ZA791266B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
JPS6028943A (ja) * 1983-07-26 1985-02-14 Sankyo Co Ltd カルバサイクリン類縁体
KR101614465B1 (ko) 2007-12-17 2016-04-21 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
US8481782B2 (en) 2010-06-03 2013-07-09 United Therapeutics Corporation Treprostinil production
US8461393B2 (en) 2011-03-02 2013-06-11 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
CH629493A5 (en) * 1976-05-11 1982-04-30 Wellcome Found Processes for preparing novel prostaglandin derivatives
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
MX4813E (es) * 1976-06-01 1982-10-19 Upjohn Co Procedimiento para preparar analogos de prostaglandinas
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
IT1098350B (it) * 1977-07-28 1985-09-07 Upjohn Co Derivati prostaglandinici
DE2743283A1 (de) * 1977-09-27 1979-04-05 Hoechst Ag Neue prostacyclin-analoga

Also Published As

Publication number Publication date
IL56892A0 (en) 1979-05-31
EP0004335A3 (de) 1979-11-28
AU4518279A (en) 1979-09-20
JPS54130558A (en) 1979-10-09
DE2811950A1 (de) 1979-12-13
EP0004335A2 (de) 1979-10-03
ZA791266B (en) 1980-03-26

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