ES472702A1 - Un metodo para la preparacion de nacil tienamicinas - Google Patents

Un metodo para la preparacion de nacil tienamicinas

Info

Publication number
ES472702A1
ES472702A1 ES472702A ES472702A ES472702A1 ES 472702 A1 ES472702 A1 ES 472702A1 ES 472702 A ES472702 A ES 472702A ES 472702 A ES472702 A ES 472702A ES 472702 A1 ES472702 A1 ES 472702A1
Authority
ES
Spain
Prior art keywords
acyl
thienamycin
carboxylic acid
thienamycins
broth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472702A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES472702A1 publication Critical patent/ES472702A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

El método de preparación de N-acil-tienamicinas es por reacción del compuesto acilo apropiado, bien como ácido carboxílico, amida del mismo, péptido del mismo o éster de alquilo inferior del mismo con tienamicina bien en caldo de fermentación o en estado intermedio de pureza. Ya que los derivados resultantes son más susceptibles a aquellas técnicas de aislamiento que emplean disolventes orgánicos, permiten la recuperación del núcleo de tionamicina con mayor eficacia a partir de caldos de fermentación y concentrados. Una vez que el derivado de tienamicina de recupera del caldo o solución, pueden separarse el grupo acilo con objeto de regenerar la tienamicina. En la representación genérica de los compuestos de la presente invención el radical acilo R puede hacerse derivar de un ácido carboxílico alifático con más de 5 átomos de carbono saturado o no saturado, sustituido o no sustituido, ácido carboxílico aromático o arilalifático o ácido carbotioico.
ES472702A 1977-08-19 1978-08-18 Un metodo para la preparacion de nacil tienamicinas Expired ES472702A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/825,884 US4135978A (en) 1977-08-19 1977-08-19 Production of n-acyl-thienamycins

Publications (1)

Publication Number Publication Date
ES472702A1 true ES472702A1 (es) 1979-02-16

Family

ID=25245141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES472702A Expired ES472702A1 (es) 1977-08-19 1978-08-18 Un metodo para la preparacion de nacil tienamicinas

Country Status (9)

Country Link
US (1) US4135978A (es)
EP (1) EP0000932B1 (es)
JP (1) JPS5455789A (es)
DE (1) DE2861197D1 (es)
DK (1) DK365578A (es)
ES (1) ES472702A1 (es)
IE (1) IE47152B1 (es)
IT (1) IT7850748A0 (es)
PT (1) PT68429A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207395A (en) * 1978-11-02 1980-06-10 Merck & Co., Inc. Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
JPS585189A (ja) * 1981-07-01 1983-01-12 Sanraku Inc 新規なアミドヒドロラ−ゼ

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB939708A (en) * 1961-06-01 1963-10-16 Beecham Res Lab Production of ª -hydroxybenzylpenicillin
CH475284A (de) * 1963-11-19 1969-07-15 Ciba Geigy Verfahren zur Herstellung von Desacetyl-7-amino-cephalosporansäure
JPS4944351B1 (es) * 1969-10-24 1974-11-27
JPS5417030B2 (es) * 1972-12-06 1979-06-27
GB1474519A (es) * 1973-05-14 1977-05-25
JPS5713280B2 (es) * 1974-03-11 1982-03-16
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
IT7850748A0 (it) 1978-08-16
IE47152B1 (en) 1983-12-28
DE2861197D1 (en) 1981-12-24
PT68429A (en) 1978-09-01
EP0000932B1 (en) 1981-10-21
EP0000932A1 (en) 1979-03-07
JPS5455789A (en) 1979-05-04
US4135978A (en) 1979-01-23
DK365578A (da) 1979-02-20
IE781673L (en) 1979-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202