ES469626A1 - Triazolothienodiazepines - Google Patents

Triazolothienodiazepines

Info

Publication number
ES469626A1
ES469626A1 ES469626A ES469626A ES469626A1 ES 469626 A1 ES469626 A1 ES 469626A1 ES 469626 A ES469626 A ES 469626A ES 469626 A ES469626 A ES 469626A ES 469626 A1 ES469626 A1 ES 469626A1
Authority
ES
Spain
Prior art keywords
ammonia
well
vii
halide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469626A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772703304 external-priority patent/DE2703304A1/en
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES469626A1 publication Critical patent/ES469626A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The 1-substituted 8-iodo-6-phenyl-4H-s-triazolo[3,4c]thieno[2,3e]1,4-diazepines of the formula I, as well as their physiologically tolerated acid addition salts, are prepared by cleaving a 4,1-oxazepine of the formula VII at the oxygen atom by treatment with a strong mineral acid, adding a phosphorus or sulphur halide to the hydro halide which forms, reacting the dihalide thus obtained with ammonia or substances giving rise to ammonia, and dehydrogenating the product. The substituents in the formulae I and VII have the meanings given in Patent Claim 1. Further preparation processes are given in Patent Claims 7 to 11 and 13. The compounds exhibit valuable therapeutic properties, in particular tranquillising, tension-releasing and sedative activity, as well as an intensive anticonvulsive effect, in association with extraordinarily low toxicity. In addition, they can be employed for improving feed uptake in mammals.
ES469626A 1977-01-27 1978-05-09 Triazolothienodiazepines Expired ES469626A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772703304 DE2703304A1 (en) 1977-01-18 1977-01-27 Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents

Publications (1)

Publication Number Publication Date
ES469626A1 true ES469626A1 (en) 1978-12-16

Family

ID=5999679

Family Applications (4)

Application Number Title Priority Date Filing Date
ES466365A Expired ES466365A1 (en) 1977-01-27 1978-01-26 Triazolothienodiazepines
ES469626A Expired ES469626A1 (en) 1977-01-27 1978-05-09 Triazolothienodiazepines
ES469625A Expired ES469625A1 (en) 1977-01-27 1978-05-09 Triazolothienodiazepines
ES469624A Expired ES469624A1 (en) 1977-01-27 1978-05-09 Triazolothienodiazepines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES466365A Expired ES466365A1 (en) 1977-01-27 1978-01-26 Triazolothienodiazepines

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES469625A Expired ES469625A1 (en) 1977-01-27 1978-05-09 Triazolothienodiazepines
ES469624A Expired ES469624A1 (en) 1977-01-27 1978-05-09 Triazolothienodiazepines

Country Status (16)

Country Link
JP (1) JPS5395998A (en)
AT (1) AT358049B (en)
AU (1) AU517925B2 (en)
BE (1) BE863365A (en)
CH (1) CH636878A5 (en)
DK (1) DK39378A (en)
ES (4) ES466365A1 (en)
FI (1) FI780156A (en)
FR (1) FR2378784A1 (en)
GB (1) GB1586532A (en)
IE (1) IE46501B1 (en)
IT (1) IT1102803B (en)
LU (1) LU78948A1 (en)
NL (1) NL7800993A (en)
NO (1) NO780294L (en)
SE (1) SE7801001L (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (en) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS

Also Published As

Publication number Publication date
NL7800993A (en) 1978-07-31
AT358049B (en) 1980-08-11
ES466365A1 (en) 1978-10-01
ATA27178A (en) 1980-01-15
LU78948A1 (en) 1979-04-09
JPS5395998A (en) 1978-08-22
AU3276778A (en) 1979-08-02
ES469625A1 (en) 1978-12-16
IT7847789A0 (en) 1978-01-25
FR2378784B1 (en) 1981-02-20
SE7801001L (en) 1978-07-28
IE780190L (en) 1978-07-27
NO780294L (en) 1978-07-28
ES469624A1 (en) 1978-12-16
GB1586532A (en) 1981-03-18
FR2378784A1 (en) 1978-08-25
DK39378A (en) 1978-07-28
FI780156A (en) 1978-07-28
IE46501B1 (en) 1983-06-29
AU517925B2 (en) 1981-09-03
IT1102803B (en) 1985-10-07
CH636878A5 (en) 1983-06-30
BE863365A (en) 1978-07-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103