ES8203917A1 - Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them. - Google Patents
Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them.Info
- Publication number
- ES8203917A1 ES8203917A1 ES503221A ES503221A ES8203917A1 ES 8203917 A1 ES8203917 A1 ES 8203917A1 ES 503221 A ES503221 A ES 503221A ES 503221 A ES503221 A ES 503221A ES 8203917 A1 ES8203917 A1 ES 8203917A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- nucleoside derivatives
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
Disclosed herein are novel adenine nucleoside derivatives of the general formula I < CHEM > and the pharmaceutically acceptable salts thereof, wherein Q represents oxygen or methylene and Rx, Ry and Rz independently represent hydrogen or an alkoxyalkanoyl grouping R1-O-R2-CO-, with the proviso that at least one of Rx, Ry and Rz is the alkoxyalkanoyl grouping R1-O-R2-CO-, the alkyl moiety R1 and the alkadiyl moiety R2 each independently containing 1 to 6 carbon atoms. The novel compounds exhibit antiviral activity and their use for this purpose is disclosed. Also disclosed are methods for the preparation of the novel compounds and pharmaceutical compositions containing them.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/162,097 US4362729A (en) | 1980-06-23 | 1980-06-23 | Alkoxyalkanoate esters of cyclaradine |
| US06/225,567 US4338310A (en) | 1981-01-16 | 1981-01-16 | Alkoxyalkanoate esters of arabinofuranosyladenine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES503221A0 ES503221A0 (en) | 1982-04-01 |
| ES8203917A1 true ES8203917A1 (en) | 1982-04-01 |
Family
ID=26858449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES503221A Expired ES8203917A1 (en) | 1980-06-23 | 1981-06-19 | Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0042596B1 (en) |
| AR (1) | AR230448A1 (en) |
| AU (1) | AU542271B2 (en) |
| CA (1) | CA1157854A (en) |
| DE (1) | DE3162644D1 (en) |
| DK (1) | DK149026C (en) |
| ES (1) | ES8203917A1 (en) |
| FI (1) | FI70903C (en) |
| HU (1) | HU183493B (en) |
| IE (1) | IE51332B1 (en) |
| IL (1) | IL63132A (en) |
| NZ (1) | NZ197458A (en) |
| PH (1) | PH17109A (en) |
| PT (1) | PT73237B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594350A (en) * | 1984-07-30 | 1986-06-10 | Reagents Of University Of Minnesota | (3-ethoxypropionate) esters of cyclaradine |
| EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
| GB9007569D0 (en) * | 1990-04-04 | 1990-05-30 | Nycomed As | Carbo-nucleoside derivatives |
| WO1991015498A2 (en) * | 1990-04-04 | 1991-10-17 | Nycomed Imaging As | Nucleoside derivatives |
| FR2759091B1 (en) * | 1997-02-06 | 1999-03-19 | Expertises Ind Et | BIOLOGICAL PROCESS FOR OBTAINING NEW ADENOSINE DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CN104297402B (en) * | 2014-07-22 | 2016-01-20 | 吉林大学 | The HPLC content assaying method of adenosine in plantain seed |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4055718A (en) * | 1976-05-17 | 1977-10-25 | Parke, Davis & Company | 9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production |
| US4055717A (en) * | 1976-05-17 | 1977-10-25 | Parke, Davis & Company | 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production |
| US4069382A (en) * | 1976-05-17 | 1978-01-17 | Parke, Davis & Company | 9-(5-O-Acyl-β-D-arabinofuranosyl)adenine compounds |
| US4138562A (en) | 1977-02-09 | 1979-02-06 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
-
1981
- 1981-06-18 AR AR285767A patent/AR230448A1/en active
- 1981-06-18 IE IE1349/81A patent/IE51332B1/en unknown
- 1981-06-18 FI FI811928A patent/FI70903C/en not_active IP Right Cessation
- 1981-06-18 NZ NZ197458A patent/NZ197458A/en unknown
- 1981-06-18 AU AU71956/81A patent/AU542271B2/en not_active Ceased
- 1981-06-18 DK DK268981A patent/DK149026C/en not_active IP Right Cessation
- 1981-06-19 IL IL63132A patent/IL63132A/en unknown
- 1981-06-19 ES ES503221A patent/ES8203917A1/en not_active Expired
- 1981-06-19 EP EP81104710A patent/EP0042596B1/en not_active Expired
- 1981-06-19 CA CA000380236A patent/CA1157854A/en not_active Expired
- 1981-06-19 DE DE8181104710T patent/DE3162644D1/en not_active Expired
- 1981-06-19 PH PH25779A patent/PH17109A/en unknown
- 1981-06-22 PT PT73237A patent/PT73237B/en unknown
- 1981-06-22 HU HU811834A patent/HU183493B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ197458A (en) | 1983-11-30 |
| IE811349L (en) | 1981-12-23 |
| PT73237B (en) | 1983-04-29 |
| EP0042596A1 (en) | 1981-12-30 |
| FI70903B (en) | 1986-07-18 |
| CA1157854A (en) | 1983-11-29 |
| ES503221A0 (en) | 1982-04-01 |
| DK149026B (en) | 1985-12-23 |
| DK268981A (en) | 1981-12-24 |
| IL63132A0 (en) | 1981-09-13 |
| DE3162644D1 (en) | 1984-04-19 |
| IE51332B1 (en) | 1986-12-10 |
| PT73237A (en) | 1981-07-01 |
| DK149026C (en) | 1986-07-07 |
| IL63132A (en) | 1984-06-29 |
| PH17109A (en) | 1984-06-01 |
| HU183493B (en) | 1984-05-28 |
| AU7195681A (en) | 1982-01-07 |
| FI70903C (en) | 1986-10-27 |
| FI811928L (en) | 1981-12-24 |
| AR230448A1 (en) | 1984-04-30 |
| EP0042596B1 (en) | 1984-03-14 |
| AU542271B2 (en) | 1985-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8206488A1 (en) | Guanine compounds and their use for the preparation of anti-viral agents. | |
| GB2183647B (en) | ||
| ES8703876A1 (en) | Purine derivatives and their pharmaceutical use. | |
| IL62111A (en) | Phenylalkenyl imidazole derivatives,their preparation and pharmaceutical compositions containing them | |
| ES427171A1 (en) | Xanthine derivatives | |
| ES8300768A1 (en) | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them. | |
| ES8703869A1 (en) | 5-Alkyl-1-phenyl-2-piperazino alkylpyrazolin-3-one compounds as well as processes and intermediates for their preparation and medicaments containing these compounds. | |
| ES8203917A1 (en) | Novel adenine nucleoside derivatives, their preparation and pharmaceutical compositions containing them. | |
| ES8501416A1 (en) | Nucleoside 5'-alkyl- or alkenylphosphate. | |
| GB1084150A (en) | ||
| EP0016411A3 (en) | 5(10- 9)abeo-ergoline derivatives, their preparation, and therapeutic compositions containing them | |
| ES8704460A1 (en) | 2-Pyridine-thiol derivatives, processes for their preparation and pharmaceutical compositions containing them. | |
| ES8301931A1 (en) | Imidazoles. | |
| ES8405021A1 (en) | Phospholipid derivatives, process for preparation thereof and pharmaceutical composition of the same. | |
| ES8300709A1 (en) | Heterocyclic compounds, compositions thereof, their preparation and use. | |
| ES485333A1 (en) | 5,6,7,8-Tetrahydro-4(3H)- quinazolinone derivatives useful as spasmolytics | |
| ES8205413A1 (en) | Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them. | |
| ES2056721A1 (en) | Aminopyrrolidine platinum compounds, a process for preparing them and pharmaceutical compositions containing them. |