ES468107A1 - Derivatives of 9-fluoroprednisolone - Google Patents

Derivatives of 9-fluoroprednisolone

Info

Publication number
ES468107A1
ES468107A1 ES468107A ES468107A ES468107A1 ES 468107 A1 ES468107 A1 ES 468107A1 ES 468107 A ES468107 A ES 468107A ES 468107 A ES468107 A ES 468107A ES 468107 A1 ES468107 A1 ES 468107A1
Authority
ES
Spain
Prior art keywords
group
derivatives
carbon atoms
fluoroprednisolone
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468107A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2712862A external-priority patent/DE2712862C2/en
Priority claimed from DE19782809732 external-priority patent/DE2809732C2/en
Application filed by Schering AG filed Critical Schering AG
Publication of ES468107A1 publication Critical patent/ES468107A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The active compounds correspond to the general formula I < IMAGE > in which R1 denotes an alkanoyl group or cycloalkanoyl group having 1 to 8 carbon atoms or a benzoyl group and X represents a fluorine atome, a chlorine atom or an alkanoyloxy group having 3 to 8 carbon atoms. The novel 9-fluoroprednisolone derivatives can be obtained by opening corresponding 9,11 beta -epoxy compounds with hydrogen fluoride or halogenating or esterifying corresponding 9-fluoro derivatives in the 21-position or cleaving a corresponding 17 alpha -cycloalkanecarbonyloxy compound with a trimethylsilyl halide or triphenylmethyl halide. Medicaments which contain at least one of the abovementioned compounds as an active component can be used for the treatment of inflammations.
ES468107A 1977-03-21 1978-03-21 Derivatives of 9-fluoroprednisolone Expired ES468107A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2712862A DE2712862C2 (en) 1977-03-21 1977-03-21 Derivatives of 9-fluorprednisolone, process for their preparation and pharmaceuticals containing them
DE19782809732 DE2809732C2 (en) 1978-03-03 1978-03-03 Derivatives of 9-fluorprednisolone, process for their production, and pharmaceutical preparations containing these active ingredients

Publications (1)

Publication Number Publication Date
ES468107A1 true ES468107A1 (en) 1979-07-01

Family

ID=25771793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468107A Expired ES468107A1 (en) 1977-03-21 1978-03-21 Derivatives of 9-fluoroprednisolone

Country Status (20)

Country Link
JP (1) JPS53130651A (en)
AT (1) AT365203B (en)
AU (1) AU525614B2 (en)
CA (1) CA1104124A (en)
CH (1) CH638226A5 (en)
CS (1) CS202591B2 (en)
DD (1) DD134955A5 (en)
DK (1) DK126378A (en)
ES (1) ES468107A1 (en)
FR (1) FR2384792A1 (en)
GB (1) GB1603281A (en)
GR (1) GR70385B (en)
IE (1) IE46584B1 (en)
IL (1) IL54308A (en)
IT (1) IT1095477B (en)
LU (1) LU79271A1 (en)
NO (1) NO151043C (en)
NZ (1) NZ186735A (en)
RO (1) RO81525B (en)
SE (1) SE431656B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853785A1 (en) * 1978-12-11 1980-06-19 Schering Ag NEW PREDNISON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND THE USE THEREOF
JPH07116215B2 (en) * 1989-04-19 1995-12-13 エスエス製薬株式会社 Novel steroid compound
JPH07213320A (en) * 1994-02-04 1995-08-15 Daiwa:Kk Bag for long sized article

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055221A1 (en) * 1970-11-10 1972-05-18 Laboratorio Chimico Farmaceutico Dr. P. Blasina S.R.L., Mailand (Italien) 17-acyloxy-3-keto-pregn-4-enes prepn - by acylating 17-hydroxy steroids in presence ofstannic chloride
CH529739A (en) * 1972-02-28 1972-10-31 Sdc Steroidi Dev Co 11,16,17,21-tetrahydroxy-3,20-diketo-1,4-pregnadienes prepn - - from cpds without 16-hydroxy grp
US3832366A (en) * 1973-07-30 1974-08-27 Squibb & Sons Inc Process for preparing 21-chloro-17-acyloxy-20-ketosteroids

Also Published As

Publication number Publication date
AT365203B (en) 1981-12-28
IT7821364A0 (en) 1978-03-20
NO151043C (en) 1985-01-30
NO151043B (en) 1984-10-22
ATA195978A (en) 1981-05-15
IE46584B1 (en) 1983-07-27
JPS53130651A (en) 1978-11-14
CA1104124A (en) 1981-06-30
CH638226A5 (en) 1983-09-15
NZ186735A (en) 1980-10-24
AU3434678A (en) 1979-09-27
FR2384792A1 (en) 1978-10-20
NO780984L (en) 1978-09-22
RO81525B (en) 1983-04-30
GB1603281A (en) 1981-11-25
CS202591B2 (en) 1981-01-30
FR2384792B1 (en) 1980-04-04
IL54308A (en) 1984-03-30
IL54308A0 (en) 1978-06-15
RO81525A (en) 1983-04-29
DK126378A (en) 1978-09-22
LU79271A1 (en) 1978-06-29
IE780545L (en) 1978-09-21
SE7803168L (en) 1978-09-22
GR70385B (en) 1982-10-05
IT1095477B (en) 1985-08-10
DD134955A5 (en) 1979-04-04
AU525614B2 (en) 1982-11-18
JPS6131116B2 (en) 1986-07-17
SE431656B (en) 1984-02-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001