ES465827A1 - Antiarrhythmic quinuclidine carboxylic acid xlidide - Google Patents

Antiarrhythmic quinuclidine carboxylic acid xlidide

Info

Publication number
ES465827A1
ES465827A1 ES465827A ES465827A ES465827A1 ES 465827 A1 ES465827 A1 ES 465827A1 ES 465827 A ES465827 A ES 465827A ES 465827 A ES465827 A ES 465827A ES 465827 A1 ES465827 A1 ES 465827A1
Authority
ES
Spain
Prior art keywords
carboxylic acid
xlidide
antiarrhythmic
formula
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465827A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mundipharma AG
Original Assignee
Mundipharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma AG filed Critical Mundipharma AG
Publication of ES465827A1 publication Critical patent/ES465827A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Production of quinuclidin-carboxylic acid and aniline derivatives of the formula: ** (Formula) ** in which R1 and R2 are hydrogen, halogen or lower alcohol, reacting quinuclidin-carboxylic acid in anhydrous chloroform in the presence of chloride oxalyl with the selected aniline derivative. This method results in the production of the desired compound in pure form with yields of 90% or greater than theoretical. Accordingly, it is a primary object of the present invention to provide new and effective antiarrhythmic compositions. (Machine-translation by Google Translate, not legally binding)
ES465827A 1977-01-19 1978-01-07 Antiarrhythmic quinuclidine carboxylic acid xlidide Expired ES465827A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL51296A IL51296A (en) 1977-01-19 1977-01-19 Antiarrhythmic composition comprising a quinuclidine-3-carboxylic acid anilide and novel method for the preparation of such anilides

Publications (1)

Publication Number Publication Date
ES465827A1 true ES465827A1 (en) 1979-01-01

Family

ID=11049358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES465827A Expired ES465827A1 (en) 1977-01-19 1978-01-07 Antiarrhythmic quinuclidine carboxylic acid xlidide

Country Status (16)

Country Link
JP (1) JPS53109952A (en)
AT (1) AT355586B (en)
AU (1) AU519089B2 (en)
CA (1) CA1107734A (en)
DE (1) DE2802208A1 (en)
DK (1) DK147180C (en)
ES (1) ES465827A1 (en)
FI (1) FI773923A (en)
FR (1) FR2384499A1 (en)
GB (2) GB1578422A (en)
IL (1) IL51296A (en)
NO (1) NO148335C (en)
NZ (1) NZ185904A (en)
PT (1) PT67401B (en)
SE (1) SE443786B (en)
ZA (1) ZA777476B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211416A1 (en) 2002-03-15 2003-09-25 Bayer Ag New azabicycloalkyl carboxylic acid N-arylamides, are alpha 7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE331841B (en) * 1967-05-23 1971-01-18 Astra Ab

Also Published As

Publication number Publication date
FI773923A (en) 1978-07-20
ZA777476B (en) 1978-10-25
PT67401B (en) 1979-05-21
NO148335C (en) 1983-09-21
ATA35378A (en) 1979-08-15
DK147180C (en) 1984-11-12
IL51296A0 (en) 1977-03-31
FR2384499A1 (en) 1978-10-20
PT67401A (en) 1978-01-01
NO148335B (en) 1983-06-13
FR2384499B1 (en) 1981-10-30
AU3248978A (en) 1979-07-26
AT355586B (en) 1980-03-10
IL51296A (en) 1983-10-31
JPS638111B2 (en) 1988-02-19
DK147180B (en) 1984-05-07
CA1107734A (en) 1981-08-25
NZ185904A (en) 1984-05-31
DK26478A (en) 1978-07-20
AU519089B2 (en) 1981-11-05
DE2802208A1 (en) 1978-07-20
JPS53109952A (en) 1978-09-26
SE443786B (en) 1986-03-10
SE7800204L (en) 1978-07-20
GB1578421A (en) 1980-11-05
NO780177L (en) 1978-07-20
GB1578422A (en) 1980-11-05

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