ES465181A1 - Un procedimiento para la preparacion del polimorfo ŸaŸ del acido 4-(2-tenoil)-2,3-diclorofenoxiacetico - Google Patents

Un procedimiento para la preparacion del polimorfo ŸaŸ del acido 4-(2-tenoil)-2,3-diclorofenoxiacetico

Info

Publication number
ES465181A1
ES465181A1 ES465181A ES465181A ES465181A1 ES 465181 A1 ES465181 A1 ES 465181A1 ES 465181 A ES465181 A ES 465181A ES 465181 A ES465181 A ES 465181A ES 465181 A1 ES465181 A1 ES 465181A1
Authority
ES
Spain
Prior art keywords
modification
polymorphic
rapidly
tyglinaphene
recrystallising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465181A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of ES465181A1 publication Critical patent/ES465181A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

Un procedimiento para la preparación del polimorfo "A" del ácido 4-(2-tenoil)-2,3-diclorofenoxiacético (ticrinafén), que comprende recristalizar el polimorfo "B" de ticrinafén: (a) en disolventes solubles en agua; (b) por suspensión en agua o en una solución acuosa; o (c) lentamente en cloroformo o dicloruro de etileno.
ES465181A 1977-01-07 1977-12-17 Un procedimiento para la preparacion del polimorfo ŸaŸ del acido 4-(2-tenoil)-2,3-diclorofenoxiacetico Expired ES465181A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB56277 1977-01-07

Publications (1)

Publication Number Publication Date
ES465181A1 true ES465181A1 (es) 1979-01-01

Family

ID=9706556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES465181A Expired ES465181A1 (es) 1977-01-07 1977-12-17 Un procedimiento para la preparacion del polimorfo ŸaŸ del acido 4-(2-tenoil)-2,3-diclorofenoxiacetico

Country Status (18)

Country Link
JP (1) JPS5387349A (es)
AU (1) AU510569B2 (es)
BE (1) BE862688A (es)
CH (1) CH634066A5 (es)
DD (1) DD134096A5 (es)
DE (1) DE2800489A1 (es)
DK (1) DK565677A (es)
ES (1) ES465181A1 (es)
FR (1) FR2376856A1 (es)
GR (1) GR66062B (es)
IL (1) IL53651A0 (es)
IT (1) IT1089800B (es)
LU (1) LU78823A1 (es)
NL (1) NL7800213A (es)
PL (1) PL203865A1 (es)
PT (1) PT67416B (es)
SE (1) SE7714959L (es)
ZA (1) ZA777531B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69503364T2 (de) * 1995-01-04 1999-04-15 Ferrer Int Verfahren zur herstellung von polymorphe b und c von 1-(2,4-dichloro-beta-((7-chloro-benzo(b)thien-3-yl)methoxy)phenethyl) imidazol-mononitrat
WO2007064595A2 (en) * 2005-11-29 2007-06-07 Bausch & Lomb Incorporated Fluocinolone acetonide drug substance polymorphic interconversion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2115042A2 (en) * 1970-11-25 1972-07-07 Cerpha 4-2-thienylketo-2,3-dichlorophenoxy acetic acid - prepn and purificn

Also Published As

Publication number Publication date
AU3169877A (en) 1979-06-28
GR66062B (es) 1981-01-15
IT1089800B (it) 1985-06-18
BE862688A (fr) 1978-07-06
FR2376856A1 (fr) 1978-08-04
PT67416B (en) 1979-05-22
FR2376856B1 (es) 1981-01-23
DK565677A (da) 1978-07-08
ZA777531B (en) 1978-10-25
DE2800489A1 (de) 1978-07-13
CH634066A5 (en) 1983-01-14
JPS5387349A (en) 1978-08-01
NL7800213A (nl) 1978-07-11
IL53651A0 (en) 1978-03-10
LU78823A1 (fr) 1978-06-09
DD134096A5 (de) 1979-02-07
AU510569B2 (en) 1980-07-03
PL203865A1 (pl) 1979-06-04
PT67416A (en) 1978-01-01
SE7714959L (sv) 1978-07-08

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