ES464835A1 - Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina - Google Patents
Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilaminaInfo
- Publication number
- ES464835A1 ES464835A1 ES464835A ES464835A ES464835A1 ES 464835 A1 ES464835 A1 ES 464835A1 ES 464835 A ES464835 A ES 464835A ES 464835 A ES464835 A ES 464835A ES 464835 A1 ES464835 A1 ES 464835A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- action
- phenoxypropanolamines
- phenoxypropan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la preparación de derivados de 2-fenil-2-hidroxietilamina de la fórmula- 01 (I): **(Fórmula-01)** en la que R1 significa hidrógeno, halógeno, hidroxi, amino, alcohilo o alcoxi; R2 significa hidrógeno, hidroxi, alcohilo o alcoxi; R3 significa hidrógeno o halógeno, alcohilo o alcoxi; R4 significa hidrógeno, metilo o etilo; y R5 y R6 significan hidrógeno, halógeno, alcohilo, alcoxi, benciloxi, hidroxi, amino, carboxi o carbalcoxi; con la condición de que en el caso de que R1 signifique hidrógeno, 4-hidroxi o 4-cloro; R2 signifique hidrógeno, R3 signifique hidrógeno, R4 signifique metilo, y R5 signifique hidrógeno o 2-halógeno, R6 no representa R4-hidroxi o 4-benciloxi, en forma de racematos, mezclas de racematos y antípodas ópticos individuales, así como las sales correspodientes, caracterizado porque además de ácidos de la fórmula-03 (XIIa): **(Formula-03)** y fórmula-04 (XIIb): **(Fórmula-04)** en donde R1 a R6 tienen los significados anteriormente indicados, se reducen con hidruros complejos, y, eventualmente, se separan grupos protectores existentes; y porque los racematos resultantes se desdoblan eventualmente, por métodos habituales, en los compuestos ópticamente activos, y/o porque las bases de la fórmula-01(I) primeramente resultantes se transforman eventualmente, por métodos habituales, en sales, o los compuetsos de la fórmula-01 (I) obtenidos como sales, se transforman en sales de otros ácidos o en bases libres.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19762606140 DE2606140A1 (de) | 1976-02-17 | 1976-02-17 | Neue derivate des 2-phenyl-2-hydroxyaethylamins |
Publications (1)
Publication Number | Publication Date |
---|---|
ES464835A1 true ES464835A1 (es) | 1979-09-16 |
Family
ID=5970017
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES455942A Expired ES455942A1 (es) | 1976-02-17 | 1977-02-16 | Procedimiento para la preparacion de derivados de 2-fenil-2 hidroxietilamina. |
ES464832A Expired ES464832A1 (es) | 1976-02-17 | 1977-12-02 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464833A Expired ES464833A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464837A Expired ES464837A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-2hidroxietilamina. |
ES464835A Expired ES464835A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina |
ES464834A Expired ES464834A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464836A Expired ES464836A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES455942A Expired ES455942A1 (es) | 1976-02-17 | 1977-02-16 | Procedimiento para la preparacion de derivados de 2-fenil-2 hidroxietilamina. |
ES464832A Expired ES464832A1 (es) | 1976-02-17 | 1977-12-02 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464833A Expired ES464833A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464837A Expired ES464837A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-2hidroxietilamina. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464834A Expired ES464834A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
ES464836A Expired ES464836A1 (es) | 1976-02-17 | 1977-12-07 | Procedimiento para la preparacion de derivados de 2-fenil-2-hidroxietilamina. |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS52100433A (es) |
AT (1) | AT355008B (es) |
AU (1) | AU512322B2 (es) |
BE (1) | BE851503A (es) |
CH (4) | CH634820A5 (es) |
DE (1) | DE2606140A1 (es) |
DK (1) | DK66177A (es) |
ES (7) | ES455942A1 (es) |
FI (1) | FI770170A (es) |
FR (1) | FR2341557A1 (es) |
GB (1) | GB1544883A (es) |
IE (1) | IE45186B1 (es) |
LU (1) | LU76774A1 (es) |
NL (1) | NL7701613A (es) |
NO (1) | NO143345C (es) |
SE (1) | SE7701724L (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3062216D1 (en) * | 1979-09-06 | 1983-04-07 | Beecham Group Plc | Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them |
DE3125870C2 (de) * | 1980-07-09 | 1994-09-15 | William John Louis | 3-Aminopropoxyphenyl Derivate, ihre Herstellung und sie enthaltende Arzneimittel |
US7998992B2 (en) | 2007-03-30 | 2011-08-16 | Institute Of Medicinal Molecular Design, Inc. | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
-
1976
- 1976-02-17 DE DE19762606140 patent/DE2606140A1/de not_active Withdrawn
-
1977
- 1977-01-20 FI FI770170A patent/FI770170A/fi not_active Application Discontinuation
- 1977-02-03 AT AT67677A patent/AT355008B/de not_active IP Right Cessation
- 1977-02-15 LU LU76774A patent/LU76774A1/xx unknown
- 1977-02-15 CH CH184777A patent/CH634820A5/de not_active IP Right Cessation
- 1977-02-16 NO NO770509A patent/NO143345C/no unknown
- 1977-02-16 GB GB6521/77A patent/GB1544883A/en not_active Expired
- 1977-02-16 ES ES455942A patent/ES455942A1/es not_active Expired
- 1977-02-16 SE SE7701724A patent/SE7701724L/xx not_active Application Discontinuation
- 1977-02-16 BE BE174995A patent/BE851503A/xx not_active IP Right Cessation
- 1977-02-16 JP JP1600477A patent/JPS52100433A/ja active Pending
- 1977-02-16 DK DK66177A patent/DK66177A/da not_active Application Discontinuation
- 1977-02-16 NL NL7701613A patent/NL7701613A/xx not_active Application Discontinuation
- 1977-02-16 AU AU22334/77A patent/AU512322B2/en not_active Expired
- 1977-02-17 FR FR7704568A patent/FR2341557A1/fr active Granted
- 1977-02-17 IE IE341/77A patent/IE45186B1/en unknown
- 1977-12-02 ES ES464832A patent/ES464832A1/es not_active Expired
- 1977-12-07 ES ES464833A patent/ES464833A1/es not_active Expired
- 1977-12-07 ES ES464837A patent/ES464837A1/es not_active Expired
- 1977-12-07 ES ES464835A patent/ES464835A1/es not_active Expired
- 1977-12-07 ES ES464834A patent/ES464834A1/es not_active Expired
- 1977-12-07 ES ES464836A patent/ES464836A1/es not_active Expired
-
1981
- 1981-08-26 CH CH550381A patent/CH634821A5/de not_active IP Right Cessation
- 1981-08-26 CH CH550481A patent/CH634822A5/de not_active IP Right Cessation
-
1982
- 1982-06-09 CH CH357282A patent/CH635569A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE45186B1 (en) | 1982-07-14 |
ES464837A1 (es) | 1978-08-01 |
SE7701724L (sv) | 1977-08-18 |
BE851503A (fr) | 1977-08-16 |
AU2233477A (en) | 1978-08-24 |
IE45186L (en) | 1977-08-17 |
ES464834A1 (es) | 1978-09-01 |
CH635569A5 (en) | 1983-04-15 |
FR2341557B1 (es) | 1980-08-14 |
JPS52100433A (en) | 1977-08-23 |
ES464833A1 (es) | 1978-09-01 |
GB1544883A (en) | 1979-04-25 |
CH634821A5 (en) | 1983-02-28 |
ES455942A1 (es) | 1978-11-01 |
AT355008B (de) | 1980-02-11 |
LU76774A1 (es) | 1978-04-13 |
ES464836A1 (es) | 1978-08-01 |
ES464832A1 (es) | 1978-09-01 |
FI770170A (es) | 1977-08-18 |
CH634822A5 (en) | 1983-02-28 |
DK66177A (da) | 1977-08-18 |
DE2606140A1 (de) | 1977-08-25 |
CH634820A5 (en) | 1983-02-28 |
NO770509L (no) | 1977-08-18 |
AU512322B2 (en) | 1980-10-02 |
ATA67677A (de) | 1979-07-15 |
NO143345B (no) | 1980-10-13 |
NL7701613A (nl) | 1977-08-19 |
NO143345C (no) | 1981-01-21 |
FR2341557A1 (fr) | 1977-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |