GB1544883A - Phenoxypropanolamines - Google Patents

Phenoxypropanolamines

Info

Publication number
GB1544883A
GB1544883A GB6521/77A GB652177A GB1544883A GB 1544883 A GB1544883 A GB 1544883A GB 6521/77 A GB6521/77 A GB 6521/77A GB 652177 A GB652177 A GB 652177A GB 1544883 A GB1544883 A GB 1544883A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
action
phenoxypropanolamines
phenoxypropan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6521/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical CH Boehringer Sohn AG and Co KG
Publication of GB1544883A publication Critical patent/GB1544883A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel 1-(2-phenyl-2-hydroxyethylamino)-3-phenoxypropan-2-ols of formula I are prepared from compounds in which at least the amino group or one of the radicals R1, R2, R5 or R6 is protected, by hydrogenolytically removing the protective group. The symbols in formula I have the meaning given in the patent claim. The compounds of formula I have a cardiovascular action and furthermore have a vascular-dilating, antihypertensive and antiarrhythmic action. <IMAGE>
GB6521/77A 1976-02-17 1977-02-16 Phenoxypropanolamines Expired GB1544883A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762606140 DE2606140A1 (en) 1976-02-17 1976-02-17 NEW DERIVATIVES OF 2-PHENYL-2-HYDROXYAETHYLAMINE

Publications (1)

Publication Number Publication Date
GB1544883A true GB1544883A (en) 1979-04-25

Family

ID=5970017

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6521/77A Expired GB1544883A (en) 1976-02-17 1977-02-16 Phenoxypropanolamines

Country Status (16)

Country Link
JP (1) JPS52100433A (en)
AT (1) AT355008B (en)
AU (1) AU512322B2 (en)
BE (1) BE851503A (en)
CH (4) CH634820A5 (en)
DE (1) DE2606140A1 (en)
DK (1) DK66177A (en)
ES (7) ES455942A1 (en)
FI (1) FI770170A (en)
FR (1) FR2341557A1 (en)
GB (1) GB1544883A (en)
IE (1) IE45186B1 (en)
LU (1) LU76774A1 (en)
NL (1) NL7701613A (en)
NO (1) NO143345C (en)
SE (1) SE7701724L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062216D1 (en) * 1979-09-06 1983-04-07 Beecham Group Plc Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
DE3125870C2 (en) * 1980-07-09 1994-09-15 William John Louis 3-aminopropoxyphenyl derivatives, their preparation and medicaments containing them
EP2141154A4 (en) 2007-03-30 2011-06-01 Inst Med Molecular Design Inc Oxazolidinone derivative having inhibitory activity on 11 -hydroxysteroid dehydrogenase type i

Also Published As

Publication number Publication date
FI770170A (en) 1977-08-18
AU2233477A (en) 1978-08-24
SE7701724L (en) 1977-08-18
NO143345B (en) 1980-10-13
DK66177A (en) 1977-08-18
IE45186B1 (en) 1982-07-14
ES464833A1 (en) 1978-09-01
CH634822A5 (en) 1983-02-28
NL7701613A (en) 1977-08-19
ES464837A1 (en) 1978-08-01
ES464836A1 (en) 1978-08-01
CH635569A5 (en) 1983-04-15
AT355008B (en) 1980-02-11
ES464835A1 (en) 1979-09-16
FR2341557B1 (en) 1980-08-14
ES464832A1 (en) 1978-09-01
LU76774A1 (en) 1978-04-13
CH634820A5 (en) 1983-02-28
ATA67677A (en) 1979-07-15
BE851503A (en) 1977-08-16
DE2606140A1 (en) 1977-08-25
ES464834A1 (en) 1978-09-01
NO143345C (en) 1981-01-21
IE45186L (en) 1977-08-17
ES455942A1 (en) 1978-11-01
FR2341557A1 (en) 1977-09-16
AU512322B2 (en) 1980-10-02
JPS52100433A (en) 1977-08-23
CH634821A5 (en) 1983-02-28
NO770509L (en) 1977-08-18

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee