ES463842A1 - 1,3-benzodioxine derivatives processes for preparing them and pharmaceutical compositions containing them - Google Patents
1,3-benzodioxine derivatives processes for preparing them and pharmaceutical compositions containing themInfo
- Publication number
- ES463842A1 ES463842A1 ES463842A ES463842A ES463842A1 ES 463842 A1 ES463842 A1 ES 463842A1 ES 463842 A ES463842 A ES 463842A ES 463842 A ES463842 A ES 463842A ES 463842 A1 ES463842 A1 ES 463842A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- esters
- phenyl
- compounds
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of formula: < IMAGE > in which R2 represents hydrogen or a C1-C5 alkyl, R3 represents hydrogen, a C1-C5 alkyl or a phenyl and R4 and R5 represent hydrogen or a halogen, are prepared by reaction of a 1-(2-hydroxy-R5-phenyl)-1-(R4-phenyl)alcohol and of an alkali metal salt of a dichloro-, dibromo- or diiodo-R2-acetic acid, and then treatment with an acid. The acids obtained can be converted to C1-C5 alkyl esters, 2,3-dihydroxypropyl esters, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl esters and dialkylaminoalkyl (C1-C4 alkyl) esters, by reaction with a corresponding alcohol or with diazomethane. Chlorine can be removed from the compounds I with R4 and/or R5 = chlorine by reacting with hydrogen in the presence of a catalyst. The compounds and their alkali metal, alkaline-earth metal, aluminium, ammonium and amine salts have a hypolipemiating activity and reduce plasmatic lipid levels they can be used in the treatment of hyperlipemia, of certain cardiac insufficiencies and of chronic anginal states.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7633409A FR2369838A1 (en) | 1976-11-05 | 1976-11-05 | NEW DERIVATIVES OF (1-3) BENZODIOXIN, A PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Publications (1)
Publication Number | Publication Date |
---|---|
ES463842A1 true ES463842A1 (en) | 1978-06-16 |
Family
ID=9179584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES463842A Expired ES463842A1 (en) | 1976-11-05 | 1977-11-04 | 1,3-benzodioxine derivatives processes for preparing them and pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5359676A (en) |
AT (1) | AT360986B (en) |
AU (1) | AU515307B2 (en) |
BE (1) | BE860500A (en) |
CH (1) | CH625517A5 (en) |
DE (1) | DE2749279C2 (en) |
DK (1) | DK152429C (en) |
ES (1) | ES463842A1 (en) |
FR (1) | FR2369838A1 (en) |
GB (1) | GB1590169A (en) |
HU (1) | HU179057B (en) |
IE (1) | IE46172B1 (en) |
IL (1) | IL53232A (en) |
LU (1) | LU78456A1 (en) |
NL (1) | NL7712172A (en) |
SE (1) | SE436879B (en) |
ZA (1) | ZA776529B (en) |
-
1976
- 1976-11-05 FR FR7633409A patent/FR2369838A1/en active Granted
-
1977
- 1977-10-17 SE SE7711669A patent/SE436879B/en not_active IP Right Cessation
- 1977-10-26 IL IL53232A patent/IL53232A/en unknown
- 1977-11-02 ZA ZA00776529A patent/ZA776529B/en unknown
- 1977-11-03 DE DE2749279A patent/DE2749279C2/en not_active Expired
- 1977-11-03 HU HU77RO948A patent/HU179057B/en not_active IP Right Cessation
- 1977-11-04 BE BE182360A patent/BE860500A/en not_active IP Right Cessation
- 1977-11-04 AU AU30329/77A patent/AU515307B2/en not_active Expired
- 1977-11-04 NL NL7712172A patent/NL7712172A/en not_active Application Discontinuation
- 1977-11-04 LU LU78456A patent/LU78456A1/xx unknown
- 1977-11-04 JP JP13163977A patent/JPS5359676A/en active Granted
- 1977-11-04 ES ES463842A patent/ES463842A1/en not_active Expired
- 1977-11-04 DK DK490477A patent/DK152429C/en not_active IP Right Cessation
- 1977-11-04 CH CH1345677A patent/CH625517A5/en not_active IP Right Cessation
- 1977-11-07 GB GB46192/77A patent/GB1590169A/en not_active Expired
- 1977-11-07 AT AT793377A patent/AT360986B/en not_active IP Right Cessation
- 1977-11-07 IE IE2268/77A patent/IE46172B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPS5359676A (en) | 1978-05-29 |
IL53232A (en) | 1982-05-31 |
DK490477A (en) | 1978-05-06 |
FR2369838A1 (en) | 1978-06-02 |
DK152429C (en) | 1988-07-25 |
SE436879B (en) | 1985-01-28 |
AU3032977A (en) | 1979-06-14 |
ZA776529B (en) | 1978-12-27 |
BE860500A (en) | 1978-05-05 |
AT360986B (en) | 1981-02-10 |
IE46172B1 (en) | 1983-03-23 |
LU78456A1 (en) | 1978-07-14 |
NL7712172A (en) | 1978-05-09 |
IL53232A0 (en) | 1977-12-30 |
ATA793377A (en) | 1980-07-15 |
DE2749279C2 (en) | 1985-11-14 |
GB1590169A (en) | 1981-05-28 |
CH625517A5 (en) | 1981-09-30 |
SE7711669L (en) | 1978-05-06 |
JPS6113473B2 (en) | 1986-04-14 |
DK152429B (en) | 1988-02-29 |
FR2369838B1 (en) | 1979-06-29 |
IE46172L (en) | 1978-05-05 |
HU179057B (en) | 1982-08-28 |
AU515307B2 (en) | 1981-03-26 |
DE2749279A1 (en) | 1978-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971103 |