ES463682A1 - Procedimiento de preparacion de nuevos derivados de la coen-zima b12. - Google Patents
Procedimiento de preparacion de nuevos derivados de la coen-zima b12.Info
- Publication number
- ES463682A1 ES463682A1 ES463682A ES463682A ES463682A1 ES 463682 A1 ES463682 A1 ES 463682A1 ES 463682 A ES463682 A ES 463682A ES 463682 A ES463682 A ES 463682A ES 463682 A1 ES463682 A1 ES 463682A1
- Authority
- ES
- Spain
- Prior art keywords
- coenzyme
- derivatives
- cobamide
- monoesters
- dibencozide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical class [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 title abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- ZIHHMGTYZOSFRC-UWWAPWIJSA-M cobamamide Chemical compound C1(/[C@](C)(CCC(=O)NC[C@H](C)OP(O)(=O)OC2[C@H]([C@H](O[C@@H]2CO)N2C3=CC(C)=C(C)C=C3N=C2)O)[C@@H](CC(N)=O)[C@]2(N1[Co+]C[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C3=NC=NC(N)=C3N=C1)O)[H])=C(C)\C([C@H](C/1(C)C)CCC(N)=O)=N\C\1=C/C([C@H]([C@@]\1(CC(N)=O)C)CCC(N)=O)=N/C/1=C(C)\C1=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O ZIHHMGTYZOSFRC-UWWAPWIJSA-M 0.000 abstract 1
- 235000006279 cobamamide Nutrition 0.000 abstract 1
- 239000011789 cobamamide Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7635533A FR2373285A1 (fr) | 1976-11-25 | 1976-11-25 | Nouveaux derives du coenzyme b 12, procede de preparation et application a titre de medicaments de ces nouveaux produits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES463682A1 true ES463682A1 (es) | 1978-07-01 |
Family
ID=9180307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES463682A Expired ES463682A1 (es) | 1976-11-25 | 1977-10-28 | Procedimiento de preparacion de nuevos derivados de la coen-zima b12. |
Country Status (13)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ217821A (en) * | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
| US5807832A (en) * | 1987-06-09 | 1998-09-15 | Biotech Australia Pty Limited | Oral delivery of biologically active substances bound to vitamin B12 |
| US4925931A (en) * | 1988-07-14 | 1990-05-15 | Mccully Kilmer S | N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof |
| US5405839A (en) * | 1989-02-28 | 1995-04-11 | Teijin Limited | Vitamin B12 derivative, preparation process thereof, and use thereof |
| WO1990010014A1 (en) * | 1989-02-28 | 1990-09-07 | Teijin Limited | New vitamin b12 derivative, production thereof, and application thereof |
| ES2108111T3 (es) * | 1991-04-02 | 1997-12-16 | Biotech Australia Pty Ltd | Sistemas de suministro oral de microparticulas. |
| DE19943167A1 (de) | 1999-09-09 | 2001-03-15 | Elenac Gmbh | Verfahren zur Herstellung von geträgerten Chromkatalysatoren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE612972A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1958-07-10 | 1900-01-01 | ||
| US3151116A (en) * | 1961-11-03 | 1964-09-29 | Ciba Geigy Corp | Certain 2-aza-indolo [2, 3-alpha] quinolizine compounds |
| GB963373A (en) * | 1961-12-11 | 1964-07-08 | Glaxo Group Ltd | Improvements in or relating to substituted cobamides |
| FR1450375A (fr) * | 1961-12-11 | 1966-06-24 | Glaxo Group Ltd | Procédé de préparation d'un co-enzyme de vitamine b12 et d'analogues de celui-ci |
| DE1670941A1 (de) * | 1967-10-14 | 1971-02-25 | Bayer Ag | Alkylsulfonylcobalamine |
-
1976
- 1976-11-25 FR FR7635533A patent/FR2373285A1/fr active Granted
-
1977
- 1977-10-28 ES ES463682A patent/ES463682A1/es not_active Expired
- 1977-11-02 AR AR269820A patent/AR214651A1/es active
- 1977-11-23 GB GB48739/77A patent/GB1549930A/en not_active Expired
- 1977-11-24 DK DK521177A patent/DK521177A/da not_active Application Discontinuation
- 1977-11-24 NL NL7712953A patent/NL7712953A/xx unknown
- 1977-11-24 MX MX776577U patent/MX4325E/es unknown
- 1977-11-24 BE BE182900A patent/BE861159A/xx not_active IP Right Cessation
- 1977-11-24 PT PT67322A patent/PT67322B/pt unknown
- 1977-11-25 DE DE19772752756 patent/DE2752756A1/de not_active Ceased
- 1977-11-25 CH CH1448677A patent/CH626897A5/fr not_active IP Right Cessation
- 1977-11-25 JP JP14081577A patent/JPS5365900A/ja active Pending
-
1980
- 1980-09-15 US US06/186,831 patent/US4364939A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CH626897A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-12-15 |
| FR2373285A1 (fr) | 1978-07-07 |
| MX4325E (es) | 1982-03-24 |
| AR214651A1 (es) | 1979-07-13 |
| PT67322B (fr) | 1979-10-10 |
| US4364939A (en) | 1982-12-21 |
| PT67322A (fr) | 1977-12-01 |
| BE861159A (fr) | 1978-05-24 |
| JPS5365900A (en) | 1978-06-12 |
| DE2752756A1 (de) | 1978-06-01 |
| GB1549930A (en) | 1979-08-08 |
| FR2373285B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-03-30 |
| NL7712953A (nl) | 1978-05-29 |
| DK521177A (da) | 1978-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980504 |