ES462388A1 - Procedure for the obtaining of optically active azabiciclohexanos. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the obtaining of optically active azabiciclohexanos. (Machine-translation by Google Translate, not legally binding)
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Wyeth Holdings LLC
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American Cyanamid Co
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Priority claimed from US05/809,339external-prioritypatent/US4131611A/en
Application filed by American Cyanamid CofiledCriticalAmerican Cyanamid Co
Publication of ES462388A1publicationCriticalpatent/ES462388A1/en
1. Procedure for obtaining optically active azabicyclohexanes, of formula: ** (Formula 01) ** in which the phenyl moiety is unsubstituted or mono- or di-substituted by the group comprising halogen, C1-C5 alkyl chain straight or mono-branched, C1-C6 alkoxy, trifluoromethyl, nitro, amino, acetamido and hydroxy, and X is selected from the group consisting of hydrogen, C1-C8 straight chain alkyl and half of the formula CnH2nR1, where n is an integer from 1 to 3 and R1 is chosen from the group consisting of phenyl and p-fluorbenzyl, characterized in that it comprises reacting a compound of the formula: ** (Formula 02) ** in which the phenyl moiety is unsubstituted or mono - or di- substituted by the group comprising halogen, straight-chain or mono-branched C1-C5-alkyl, C1-C6-alkoxy, trifluoromethyl, nitro, amino, acetamido and hydroxy, X is chosen from the group consisting of hydrogen, C1-alkyl -C8 straight-chain and one-half of formula CnH2nR1, where n is an integer ro between 1 and 3 and R1 is selected from the group consisting of phenyl and p-fluorbenzyl; and R is selected from the group consisting of hydrogen and oxygen, provided that at least one R must be oxygen, with a hydride reducing agent in an inert aprotic solvent at a temperature of from about -70ºC to about 125ºC. (Machine-translation by Google Translate, not legally binding)
ES462388A1976-09-151977-09-15Procedure for the obtaining of optically active azabiciclohexanos. (Machine-translation by Google Translate, not legally binding)
ExpiredES462388A1
(en)