ES459832A1 - Procedimiento para preparar un aminoglicosido de 2-deoxies- treptamina. - Google Patents
Procedimiento para preparar un aminoglicosido de 2-deoxies- treptamina.Info
- Publication number
- ES459832A1 ES459832A1 ES459832A ES459832A ES459832A1 ES 459832 A1 ES459832 A1 ES 459832A1 ES 459832 A ES459832 A ES 459832A ES 459832 A ES459832 A ES 459832A ES 459832 A1 ES459832 A1 ES 459832A1
- Authority
- ES
- Spain
- Prior art keywords
- deoxystreptamine
- aminoglycosides
- amino group
- antibacterial agents
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940126575 aminoglycoside Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- DTFAJAKTSMLKAT-JDCCYXBGSA-N 2-deoxystreptamine Chemical compound N[C@H]1C[C@@H](N)[C@H](O)[C@@H](O)[C@@H]1O DTFAJAKTSMLKAT-JDCCYXBGSA-N 0.000 abstract 5
- 125000003277 amino group Chemical group 0.000 abstract 3
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229930193140 Neomycin Natural products 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 229960002518 gentamicin Drugs 0.000 abstract 1
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 1
- 208000027136 gram-positive bacterial infections Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229930027917 kanamycin Natural products 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960004927 neomycin Drugs 0.000 abstract 1
- 229960003485 ribostamycin Drugs 0.000 abstract 1
- 229930190553 ribostamycin Natural products 0.000 abstract 1
- NSKGQURZWSPSBC-NLZFXWNVSA-N ribostamycin Chemical compound N[C@H]1[C@H](O)[C@@H](O)[C@H](CN)O[C@@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](CO)O2)O)[C@H](O)[C@@H](N)C[C@H]1N NSKGQURZWSPSBC-NLZFXWNVSA-N 0.000 abstract 1
- NSKGQURZWSPSBC-UHFFFAOYSA-N ribostamycin A Natural products NC1C(O)C(O)C(CN)OC1OC1C(OC2C(C(O)C(CO)O2)O)C(O)C(N)CC1N NSKGQURZWSPSBC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000707 tobramycin Drugs 0.000 abstract 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 208000019206 urinary tract infection Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB24989/76A GB1530202A (en) | 1976-06-16 | 1976-06-16 | Aminoglycosides |
| GB4014576 | 1976-09-28 | ||
| GB5129476 | 1976-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459832A1 true ES459832A1 (es) | 1978-12-16 |
Family
ID=27258386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES459832A Expired ES459832A1 (es) | 1976-06-16 | 1977-06-16 | Procedimiento para preparar un aminoglicosido de 2-deoxies- treptamina. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4214074A (en:Method) |
| JP (1) | JPS52153943A (en:Method) |
| AR (1) | AR222781A1 (en:Method) |
| AT (1) | AT350722B (en:Method) |
| BG (1) | BG28071A3 (en:Method) |
| CA (1) | CA1075235A (en:Method) |
| CH (1) | CH606079A5 (en:Method) |
| CS (1) | CS203157B2 (en:Method) |
| DD (1) | DD131019A5 (en:Method) |
| DE (1) | DE2726839C3 (en:Method) |
| DK (1) | DK147942C (en:Method) |
| EG (1) | EG12742A (en:Method) |
| ES (1) | ES459832A1 (en:Method) |
| FI (1) | FI771873A7 (en:Method) |
| FR (1) | FR2355029A1 (en:Method) |
| GR (1) | GR66411B (en:Method) |
| HU (1) | HU179054B (en:Method) |
| IE (1) | IE45389B1 (en:Method) |
| IL (1) | IL52181A (en:Method) |
| LU (1) | LU77557A1 (en:Method) |
| MX (1) | MX4323E (en:Method) |
| NL (1) | NL170736C (en:Method) |
| NO (1) | NO144851C (en:Method) |
| NZ (1) | NZ184213A (en:Method) |
| PH (1) | PH14663A (en:Method) |
| PL (1) | PL108094B1 (en:Method) |
| PT (1) | PT66669B (en:Method) |
| RO (1) | RO73516A (en:Method) |
| SE (1) | SE7706944L (en:Method) |
| SU (1) | SU865128A3 (en:Method) |
| YU (1) | YU132577A (en:Method) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK308878A (da) * | 1977-08-18 | 1979-02-19 | Pfizer | Aminoglyosidderivater og fremgangsmaader til deres fremstilling |
| DE2832268A1 (de) | 1978-07-22 | 1980-01-31 | Bayer Ag | Pseudotrisaccharide |
| DE2928183A1 (de) * | 1979-07-12 | 1981-01-29 | Bayer Ag | 1-n-alkylsisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS5931266A (ja) * | 1982-08-11 | 1984-02-20 | 株式会社日立製作所 | エレベ−タ−の制御装置 |
| KR100450607B1 (ko) * | 2002-07-11 | 2004-09-30 | 경동제약 주식회사 | 가라민 유도체의 제조방법 |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| CN103360440B (zh) | 2007-11-21 | 2016-08-31 | 尔察祯有限公司 | 抗菌性氨基糖苷类似物 |
| WO2010132777A2 (en) * | 2009-05-14 | 2010-11-18 | Achaogen, Inc. | Treatment of urinary tract infections with antibacterial aminoglycoside compounds |
| WO2010132757A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
| WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
| WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1033394A (en) * | 1962-04-03 | 1966-06-22 | Rit Rech Ind Therapeut | New therapeutic agents |
| US4002742A (en) * | 1974-03-19 | 1977-01-11 | Schering Corporation | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor |
| US4000262A (en) * | 1974-11-29 | 1976-12-28 | Schering Corporation | 5-epi-amino and 5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines 1-n-alkyl-5-epi-amino and 1-n-alkyl-5-epi-azido-4,6-di-o-(aminoglycosyl)-2,5-dideoxystreptamines |
| US4000261A (en) * | 1974-11-29 | 1976-12-28 | Schering Corporation | 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor |
| US4062947A (en) * | 1975-11-04 | 1977-12-13 | Schering Corporation | Di-N-alkylaminoglycosides, methods for their manufacture and novel intermediates useful therein, method for their use as antibacterial agents and pharmaceutical compositions useful therefor |
| US4085208A (en) * | 1976-06-21 | 1978-04-18 | Schering Corporation | Process for preparing 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and novel 1-epimers and 1-N-alkyl derivatives produced thereby; methods for the use of the 1-epimer derivatives as antibacterial agents and compositions useful therefor |
-
1977
- 1977-05-26 NZ NZ184213A patent/NZ184213A/xx unknown
- 1977-05-27 YU YU01325/77A patent/YU132577A/xx unknown
- 1977-05-27 IL IL52181A patent/IL52181A/xx unknown
- 1977-05-30 EG EG329/77A patent/EG12742A/xx active
- 1977-05-31 PH PH19833A patent/PH14663A/en unknown
- 1977-06-02 MX MX775775U patent/MX4323E/es unknown
- 1977-06-03 CA CA279,773A patent/CA1075235A/en not_active Expired
- 1977-06-03 AR AR267934A patent/AR222781A1/es active
- 1977-06-08 CS CS773790A patent/CS203157B2/cs unknown
- 1977-06-13 AT AT414277A patent/AT350722B/de not_active IP Right Cessation
- 1977-06-13 BG BG036611A patent/BG28071A3/xx unknown
- 1977-06-14 GR GR53699A patent/GR66411B/el unknown
- 1977-06-14 DE DE2726839A patent/DE2726839C3/de not_active Expired
- 1977-06-14 PT PT66669A patent/PT66669B/pt unknown
- 1977-06-14 NO NO772089A patent/NO144851C/no unknown
- 1977-06-14 NL NLAANVRAGE7706514,A patent/NL170736C/xx not_active IP Right Cessation
- 1977-06-14 FI FI771873A patent/FI771873A7/fi not_active Application Discontinuation
- 1977-06-15 SE SE7706944A patent/SE7706944L/xx not_active Application Discontinuation
- 1977-06-15 SU SU772494017A patent/SU865128A3/ru active
- 1977-06-15 PL PL1977198872A patent/PL108094B1/pl not_active IP Right Cessation
- 1977-06-15 JP JP7094477A patent/JPS52153943A/ja active Granted
- 1977-06-15 FR FR7718367A patent/FR2355029A1/fr active Granted
- 1977-06-15 DD DD7700199503A patent/DD131019A5/xx unknown
- 1977-06-15 RO RO7790693A patent/RO73516A/ro unknown
- 1977-06-15 HU HU77PI580A patent/HU179054B/hu unknown
- 1977-06-15 CH CH737577A patent/CH606079A5/xx not_active IP Right Cessation
- 1977-06-15 DK DK265577A patent/DK147942C/da not_active IP Right Cessation
- 1977-06-15 IE IE1222/77A patent/IE45389B1/en unknown
- 1977-06-16 LU LU77557A patent/LU77557A1/xx unknown
- 1977-06-16 ES ES459832A patent/ES459832A1/es not_active Expired
-
1978
- 1978-11-07 US US05/958,409 patent/US4214074A/en not_active Expired - Lifetime
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