ES456287A1 - Procedimiento para la preparacion de derivados de ladano po-lioxigenados. - Google Patents
Procedimiento para la preparacion de derivados de ladano po-lioxigenados.Info
- Publication number
- ES456287A1 ES456287A1 ES456287A ES456287A ES456287A1 ES 456287 A1 ES456287 A1 ES 456287A1 ES 456287 A ES456287 A ES 456287A ES 456287 A ES456287 A ES 456287A ES 456287 A1 ES456287 A1 ES 456287A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- derivatives
- formula
- polyoxygenated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001761 labdane diterpenoid derivatives Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polyethers (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762654796 DE2654796A1 (de) | 1976-12-03 | 1976-12-03 | Polyoxygenierte labdan-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES456287A1 true ES456287A1 (es) | 1978-06-01 |
Family
ID=5994581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES456287A Expired ES456287A1 (es) | 1976-12-03 | 1977-02-25 | Procedimiento para la preparacion de derivados de ladano po-lioxigenados. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4134986A (OSRAM) |
| JP (1) | JPS5371077A (OSRAM) |
| BE (1) | BE852060A (OSRAM) |
| DE (1) | DE2654796A1 (OSRAM) |
| DK (1) | DK55377A (OSRAM) |
| ES (1) | ES456287A1 (OSRAM) |
| FI (1) | FI770401A7 (OSRAM) |
| FR (1) | FR2372822A1 (OSRAM) |
| IT (1) | IT1075566B (OSRAM) |
| NL (1) | NL7702129A (OSRAM) |
| NO (1) | NO770401L (OSRAM) |
| SE (1) | SE7701310L (OSRAM) |
| ZA (1) | ZA771052B (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4517200A (en) * | 1982-12-27 | 1985-05-14 | Schering-Plough Corporation | Method for treating allergic reactions with forskolin |
| US4782082A (en) * | 1982-12-27 | 1988-11-01 | Schering Corporation | Method for treating allergic reactions with Forskolin |
| US4564626A (en) * | 1983-04-01 | 1986-01-14 | Schering Corporation | Methods of inducing bronchodilation |
| DE3314999A1 (de) * | 1983-04-26 | 1985-03-14 | Behringwerke Ag, 3550 Marburg | Verwendung des diterpen-derivates forskolin zur immunstimulation |
| US4476140A (en) * | 1983-05-16 | 1984-10-09 | Yale University | Composition and method for treatment of glaucoma |
| US4751224A (en) * | 1983-07-21 | 1988-06-14 | Brown University Research Foundation | Treatment of metastasis |
| AU2690684A (en) * | 1984-02-24 | 1985-09-10 | Kenji Adachi | Methods and pharmaceutical compositions for the treatment of hyperplastic diseases of the skin |
| US4678775A (en) * | 1984-05-01 | 1987-07-07 | Nathanson James A | Method of controlling pests |
| US4783457A (en) * | 1984-05-01 | 1988-11-08 | The General Hospital Corporation | Pest controlling agents |
| SE454051B (sv) * | 1984-10-09 | 1988-03-28 | Marcus Lindblom | Som bergdubb tjenande fasthallningsorgan |
| MC1710A1 (fr) * | 1984-11-26 | 1986-09-22 | Ciba Geigy Ag | Composes azotes de derives oxo |
| DE3502685A1 (de) * | 1985-01-26 | 1986-09-04 | Hoechst Ag, 6230 Frankfurt | Forskolin, seine analoge und derivate, verfahren zu deren herstellung mittels mikrobieller umwandlungen und die anwendung dieser verbindungen als arzneimittel |
| DE3581725D1 (de) * | 1984-12-14 | 1991-03-14 | Hoechst Roussel Pharma | Aminoacyllabdane, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel. |
| US4673752A (en) * | 1984-12-14 | 1987-06-16 | Hoechst-Roussel Pharmaceuticals Inc. | Aminoacyllabdanes |
| US4672115A (en) * | 1984-12-14 | 1987-06-09 | Hoechst-Roussel Pharmaceuticals Inc. | Process for preparing aminoacyllabdanes |
| DE3502686A1 (de) * | 1985-01-26 | 1986-08-14 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von labdan-derivaten und ihre verwendung als arzneimittel |
| US4639446A (en) * | 1984-12-14 | 1987-01-27 | Hoechst-Roussel Pharmaceuticals Inc. | Aminoacyllabdanes, pharmaceutical compositions and use |
| US4963537A (en) * | 1985-03-01 | 1990-10-16 | Hoechst-Roussel Pharmaceuticals Inc. | Labdane compounds, pharmaceutical compositions and use |
| IN163242B (OSRAM) | 1985-05-03 | 1988-08-27 | Hoechst India | |
| AU591196B2 (en) * | 1985-11-15 | 1989-11-30 | Nippon Kayaku Kabushiki Kaisha | Novel forskolin derivatives |
| US4734513A (en) * | 1986-03-31 | 1988-03-29 | Hoechst-Roussel Pharmaceuticals Inc. | Method of synthesizing forskolin from 9-deoxyforskolin |
| US5008407A (en) * | 1986-03-31 | 1991-04-16 | Hoechst-Roussel Pharmaceuticals Inc. | Method of synthesizing forskolin from 9-deoxyforskolin |
| US5247097A (en) * | 1986-08-28 | 1993-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Oxolabdanes |
| US4740522A (en) * | 1986-08-28 | 1988-04-26 | Hoechst-Roussel Pharmaceuticals Inc. | Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure |
| US4871764A (en) * | 1986-11-20 | 1989-10-03 | Hoechst-Roussel Pharmaceuticals, Inc. | 12-Halogenated forskolin derivatives |
| US4978678A (en) * | 1986-11-20 | 1990-12-18 | Hoechst-Roussel Pharmaceuticals Inc. | 12-halogenated forskolin derivatives |
| US5646175A (en) * | 1987-12-28 | 1997-07-08 | Hoechst Marion Roussel, Inc. | Carbamoyloxylabdane compounds |
| US4920146A (en) * | 1986-12-29 | 1990-04-24 | Hoechst Roussel Pharmaceuticals Inc. | Carbamoyloxylabdane compounds useful in reducing intraocular pressure |
| US4770376A (en) * | 1987-03-19 | 1988-09-13 | Lindblom Erik M | Fastener device which functions as a rock dowel |
| DE3730748A1 (de) * | 1987-06-06 | 1988-12-22 | Hoechst Ag | Neue polyoxygenierte labdanderivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPH0739408B2 (ja) * | 1987-06-29 | 1995-05-01 | 日本化薬株式会社 | ６−アシルー７ーデアセチルフオルスコリン誘導体の新規製造法 |
| US5302730A (en) * | 1987-06-29 | 1994-04-12 | Nippon Kayaku Kk | Process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives |
| US4909799A (en) * | 1987-09-18 | 1990-03-20 | Olav Thulesius | Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics |
| US5846992A (en) * | 1987-10-08 | 1998-12-08 | Hoechst Marion Roussel, Inc. | Synergistic intraocular pressure lowering combinations |
| US4902696A (en) * | 1987-10-08 | 1990-02-20 | Hoechst-Roussel Pharmaceuticals, Inc. | Synergistic intraocular pressure lowering combinations |
| US4883793A (en) * | 1988-05-09 | 1989-11-28 | Hoechst-Roussel Pharmaceuticals Inc. | Hydrazinocarbonyloxylabdanes for treating cardiac failure |
| EP0370379B1 (en) * | 1988-11-19 | 1992-09-09 | Hoechst Aktiengesellschaft | Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a) isoquinolin-4-one derivatives and their use |
| US5177207A (en) * | 1989-01-11 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals, Inc. | 7-aryl and heteroaryl ethers of desacetylforskolin |
| US4999351A (en) * | 1989-01-11 | 1991-03-12 | Hoechst-Roussel Pharmaceuticals, Inc. | 7-aryl and heteroaryl ethers of desacetylforskolin |
| US5093336A (en) * | 1989-07-06 | 1992-03-03 | Hoechat-Roussel Pharmaceuticals, Inc. | 6- and 7-deoxyforskolin and derivatives thereof |
| US5145855A (en) * | 1989-07-06 | 1992-09-08 | Hoechst Roussel Pharmaceuticals, Inc. | 6- and 7-deoxyforskolin and derivatives thereof |
| JP3557095B2 (ja) * | 1998-04-20 | 2004-08-25 | 高砂香料工業株式会社 | メラニン産生抑制剤 |
| DE60130007T2 (de) * | 2000-06-27 | 2008-04-30 | Qualilife Pharmaceuticals Inc. | Zusammensetzungen und verfahren zur behandlung der weiblichen sexuellen reaktion |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3631039A (en) * | 1969-04-21 | 1971-12-28 | Hoffmann La Roche | 2-amino ethyl-2-hydroxy - 6-vinyl tetrahydropyrans tautomers and optical enantiomers thereof |
-
1976
- 1976-12-03 DE DE19762654796 patent/DE2654796A1/de active Pending
-
1977
- 1977-02-07 FI FI770401A patent/FI770401A7/fi not_active Application Discontinuation
- 1977-02-07 NO NO770401A patent/NO770401L/no unknown
- 1977-02-07 SE SE7701310A patent/SE7701310L/xx unknown
- 1977-02-09 DK DK55377A patent/DK55377A/da not_active Application Discontinuation
- 1977-02-11 IT IT20235/77A patent/IT1075566B/it active
- 1977-02-14 JP JP1431877A patent/JPS5371077A/ja active Pending
- 1977-02-22 ZA ZA00771052A patent/ZA771052B/xx unknown
- 1977-02-25 ES ES456287A patent/ES456287A1/es not_active Expired
- 1977-02-28 NL NL7702129A patent/NL7702129A/xx not_active Application Discontinuation
- 1977-03-03 BE BE175454A patent/BE852060A/xx unknown
- 1977-03-09 FR FR7706933A patent/FR2372822A1/fr active Granted
- 1977-04-15 US US05/787,961 patent/US4134986A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ZA771052B (en) | 1978-02-22 |
| BE852060A (fr) | 1977-09-05 |
| US4134986A (en) | 1979-01-16 |
| SE7701310L (sv) | 1978-06-04 |
| NO770401L (no) | 1978-06-06 |
| DK55377A (da) | 1978-06-04 |
| IT1075566B (it) | 1985-04-22 |
| DE2654796A1 (de) | 1978-06-08 |
| FR2372822A1 (fr) | 1978-06-30 |
| JPS5371077A (en) | 1978-06-24 |
| FR2372822B1 (OSRAM) | 1980-02-01 |
| NL7702129A (nl) | 1978-06-06 |
| FI770401A7 (fi) | 1978-06-04 |
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