ES453892A1 - Procedure for the preparation of 2-amino-quinazoline derivatives and their physiologically useful salts. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 2-amino-quinazoline derivatives and their physiologically useful salts. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES453892A1 ES453892A1 ES453892A ES453892A ES453892A1 ES 453892 A1 ES453892 A1 ES 453892A1 ES 453892 A ES453892 A ES 453892A ES 453892 A ES453892 A ES 453892A ES 453892 A1 ES453892 A1 ES 453892A1
- Authority
- ES
- Spain
- Prior art keywords
- substituents
- groups
- nitro
- group
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A process for the preparation of certain substituted 2-amino-quinazoline derivatives, which respond to the following general formula (I) **(See formula)** in which R1 represents hydrogen or one or more alkyl groups, halogen atoms, nitro groups or alkoxy groups, located at any of positions 5, 6, 7 or 8 of the quinazoline ring; R represents hydrogen, a linear or branched alkyl group, a thioalkoxy group or an aryl radical that can be a carrier for substituents, with special reference to one or more halogen, nitro or alkoxy groups; and R3 and R4, which must never have the hydrogen significance, represent either linear or branched alkyl groups, aryl groups with or without substituents such as halogen or nitro, aralkyl groups, or, together, a chain selected from the following - (CH2) m-, - (CH2) n-X- (CH2) m or - (CH2) n-N (R5) - (CH2) - where n, m and p can take values between 2 and 6, X represents an oxygen or a sulfur, and R5 represents a lower alkyl group, or an aryl group with or without substituents, or an aralkyl group with or without substituents; characterized in that a substituted chloroformamidine, of general formula (II), in which the substituents R1, R3 and R4 maintain the aforementioned significance, is reacted with a cyano-compound of general formula (IIl), in which the substituent R2 has the above significance, in the presence of a Lewis (IV) acid, **(See formula)** in the absence of solvent or in an inert liquid medium, with the only limitation, in this case, that the temperature necessary to carry out the process may be imposed, which, depending on the case, falls within the range 50-150ºC, the invention also relates to the physiologically acceptable salts that the compounds of formula (I) can form with acids; more specifically, to salts capable of facilitating the distribution and transport of the active molecule (I). (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES453892A ES453892A1 (en) | 1976-12-02 | 1976-12-02 | Procedure for the preparation of 2-amino-quinazoline derivatives and their physiologically useful salts. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES453892A ES453892A1 (en) | 1976-12-02 | 1976-12-02 | Procedure for the preparation of 2-amino-quinazoline derivatives and their physiologically useful salts. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453892A1 true ES453892A1 (en) | 1977-11-01 |
Family
ID=8472712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453892A Expired ES453892A1 (en) | 1976-12-02 | 1976-12-02 | Procedure for the preparation of 2-amino-quinazoline derivatives and their physiologically useful salts. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES453892A1 (en) |
-
1976
- 1976-12-02 ES ES453892A patent/ES453892A1/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991018 |