ES453839A1 - Procedure for the preparation of 5-sulfamilbenzoic acid derivatives substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 5-sulfamilbenzoic acid derivatives substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES453839A1 ES453839A1 ES453839A ES453839A ES453839A1 ES 453839 A1 ES453839 A1 ES 453839A1 ES 453839 A ES453839 A ES 453839A ES 453839 A ES453839 A ES 453839A ES 453839 A1 ES453839 A1 ES 453839A1
- Authority
- ES
- Spain
- Prior art keywords
- alcohol
- formula
- hydrogen
- carbon atoms
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pyrrole Compounds (AREA)
Abstract
Process for the preparation of 5-sulfamyl benzoic acid derivatives substituted with heterocyclic radicals, of the general formula I **(See formula)** wherein the radicals R1 and R2 are the same or different and signify hydrogen or alcohol of 1 to 4 carbon atoms; R3 means straight or branched chain hydrogen or alcohol of 1 to 4 carbon atoms; X stands for halogen, CF3, benzyl optionally substituted on the phenyl nucleus in position 4 with alcohol with 1 to 4 carbon atoms, or one of the groups O-R4, S-R4, SO-R4, SO2-R4 and NR4R5, wherein R4 represents phenyl optionally substituted in the 3,4 and/or 5 positions with Hal, OH, NH, alcohol- or dialcohil (1-4 C) -amino, alcohol (1-4 C) or alkoxy from 1 to 4 carbon atoms, and R5 signifies hydrogen, the group NR4R5 may also signify a saturated 5- to 6-membered heterocyclic ring, which is eventually interrupted by O, N or S atoms and R6 and R7 signify hydrogen, alcohol (1-4 C) possibly branched, benzyl, phenyl or mononuclear heteroaromatic rings, as well as their pharmaceutically acceptable salts with bases or acids, characterized in that corresponding 3-N-pyrrole compounds of the general formula VII are reduced **(See formula)** by catalytic hydrogenation; and optionally in compounds of formula I, double bonds are catalytically hydrogenated or double bonds are introduced by separation of hydrogen halide and/or free carboxylic acids of formula I (R3 = H) are esterified with aliphatic alcohols of 1 to 4 atoms of carbon and/or carboxylic acid esters of the general formula I are transformed, by acidic or alkaline hydrolysis, into the carboxylic acids (R3 = H) and/or removal of a protecting group, hydroxy, amino or mercapto groups are released and/or carboxylic acids of formula I (R3 = H) are transformed, by treatment with bases or with acids, into their pharmaceutically acceptable salts. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES453839A ES453839A1 (en) | 1976-12-01 | 1976-12-01 | Procedure for the preparation of 5-sulfamilbenzoic acid derivatives substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES453839A ES453839A1 (en) | 1976-12-01 | 1976-12-01 | Procedure for the preparation of 5-sulfamilbenzoic acid derivatives substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453839A1 true ES453839A1 (en) | 1977-11-16 |
Family
ID=8472703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453839A Expired ES453839A1 (en) | 1976-12-01 | 1976-12-01 | Procedure for the preparation of 5-sulfamilbenzoic acid derivatives substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES453839A1 (en) |
-
1976
- 1976-12-01 ES ES453839A patent/ES453839A1/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970728 |