ES452264A1 - Prostaglandin derivatives - Google Patents

Prostaglandin derivatives

Info

Publication number
ES452264A1
ES452264A1 ES452264A ES452264A ES452264A1 ES 452264 A1 ES452264 A1 ES 452264A1 ES 452264 A ES452264 A ES 452264A ES 452264 A ES452264 A ES 452264A ES 452264 A1 ES452264 A1 ES 452264A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
alkyl
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452264A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES452264A1 publication Critical patent/ES452264A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedure for the preparation of racemic and optically active compounds of the formula I **(See formula)** in which J stands for hydrogen or hydroxy; K stands for carbonyl or carbinol; L is ethylene or vinylene; Q is hydrogen, a non-toxic and pharmaceutically acceptable cation or lower alkyl; one of the symbols R1, R2 and R3 is C1-6 alkyl and the other two are hydrogen; both J and the hydroxy group can be in alpha or beta position, characterized in that it comprises reacting a compound of formula II **(See formula)** (where Q1 is alkyl; L has the same meaning as indicated above and J is hydrogen or hydroxy, which is protected in the form of an acetal or a trialkylsilyl ether) with a nucleophilic cuprate reactant of formula III **(See formula)** (Wherein R1, R2 and R3 are as indicated above; Rx is a suitable group substantially nontransferable in the enon system under the reaction conditions used, preferably an aliphatic alkyne, triphenoxide, tertiary butoxide, phenoxide, or a group of the formula IV **(See formula)** where R'means a group that can be easily cleaved under mild acidic or alkaline conditions), converting, if desired, an ester of the formula I thus obtained -in which Q is alkyl- into the corresponding free acid -in which Q it is hydrogen- or a non-toxic and pharmaceutically acceptable salt thereof and, if desired, reducing a compound of formula I - where K is carbonyl - to the corresponding compound of formula I - where K is carbinol. (Machine-translation by Google Translate, not legally binding)
ES452264A 1975-09-26 1976-09-23 Prostaglandin derivatives Expired ES452264A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75CI1612A HU174274B (en) 1975-09-26 1975-09-26 Process for producing substituted cyclohexylidene-prostaglandin analogues

Publications (1)

Publication Number Publication Date
ES452264A1 true ES452264A1 (en) 1977-11-01

Family

ID=10994581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES452264A Expired ES452264A1 (en) 1975-09-26 1976-09-23 Prostaglandin derivatives

Country Status (21)

Country Link
JP (1) JPS5257151A (en)
AR (1) AR213292A1 (en)
AT (1) AT353990B (en)
AU (1) AU1806476A (en)
BE (1) BE846551A (en)
CS (1) CS189789B2 (en)
DD (1) DD127163A5 (en)
DE (1) DE2642558A1 (en)
DK (1) DK426676A (en)
ES (1) ES452264A1 (en)
FI (1) FI762738A (en)
FR (1) FR2325367A1 (en)
GB (1) GB1515789A (en)
GR (1) GR61671B (en)
HU (1) HU174274B (en)
IL (1) IL50532A0 (en)
NL (1) NL7610635A (en)
NO (1) NO763278L (en)
PL (1) PL105784B1 (en)
SE (1) SE7610513L (en)
SU (1) SU701532A3 (en)

Also Published As

Publication number Publication date
NL7610635A (en) 1977-03-29
DE2642558A1 (en) 1977-04-07
AR213292A1 (en) 1979-01-15
AU1806476A (en) 1978-04-06
JPS5257151A (en) 1977-05-11
CS189789B2 (en) 1979-04-30
ATA701276A (en) 1979-05-15
AT353990B (en) 1979-12-10
IL50532A0 (en) 1976-11-30
PL105784B1 (en) 1979-10-31
DD127163A5 (en) 1977-09-07
GB1515789A (en) 1978-06-28
SU701532A3 (en) 1979-11-30
BE846551A (en) 1977-01-17
SE7610513L (en) 1977-03-27
FR2325367B1 (en) 1979-03-23
NO763278L (en) 1977-03-29
GR61671B (en) 1978-12-05
FI762738A (en) 1977-03-27
HU174274B (en) 1979-12-28
DK426676A (en) 1977-03-27
FR2325367A1 (en) 1977-04-22

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