ES446353A1 - Procedimiento para preparar cefalosporinas. - Google Patents
Procedimiento para preparar cefalosporinas.Info
- Publication number
- ES446353A1 ES446353A1 ES76446353A ES446353A ES446353A1 ES 446353 A1 ES446353 A1 ES 446353A1 ES 76446353 A ES76446353 A ES 76446353A ES 446353 A ES446353 A ES 446353A ES 446353 A1 ES446353 A1 ES 446353A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- reaction
- lower alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 indan-5-yl Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052751 metal Chemical class 0.000 abstract 2
- 239000002184 metal Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7512813A GB1542397A (en) | 1975-03-27 | 1975-03-27 | Cephem compounds |
| GB4393575 | 1975-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES446353A1 true ES446353A1 (es) | 1977-11-16 |
Family
ID=26249284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES76446353A Expired ES446353A1 (es) | 1975-03-27 | 1976-03-25 | Procedimiento para preparar cefalosporinas. |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS51138694A (cg-RX-API-DMAC7.html) |
| AU (1) | AU1244276A (cg-RX-API-DMAC7.html) |
| DD (1) | DD124601A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2612760A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK132876A (cg-RX-API-DMAC7.html) |
| ES (1) | ES446353A1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI760793A7 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2305186A1 (cg-RX-API-DMAC7.html) |
| IE (1) | IE43541B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL49183A0 (cg-RX-API-DMAC7.html) |
| LU (1) | LU74651A1 (cg-RX-API-DMAC7.html) |
| NL (1) | NL7603116A (cg-RX-API-DMAC7.html) |
| NO (1) | NO761052L (cg-RX-API-DMAC7.html) |
| PT (1) | PT64951B (cg-RX-API-DMAC7.html) |
| SE (1) | SE7603699L (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3149076A1 (fr) | 2023-05-25 | 2024-11-29 | Psa Automobiles Sa | Système de traitement d’air pour véhicule automobile pourvu d’un filtre HEPA |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA999574A (en) * | 1972-06-14 | 1976-11-09 | Smith Kline And French Canada Ltd. | 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins |
| FR2215942B1 (cg-RX-API-DMAC7.html) * | 1973-01-31 | 1978-12-22 | Bristol Myers Co | |
| US3989694A (en) * | 1974-12-27 | 1976-11-02 | Smithkline Corporation | 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins |
-
1976
- 1976-03-09 IL IL49183A patent/IL49183A0/xx unknown
- 1976-03-25 DE DE19762612760 patent/DE2612760A1/de active Pending
- 1976-03-25 ES ES76446353A patent/ES446353A1/es not_active Expired
- 1976-03-25 FI FI760793A patent/FI760793A7/fi not_active Application Discontinuation
- 1976-03-25 DK DK132876A patent/DK132876A/da unknown
- 1976-03-25 IE IE624/76A patent/IE43541B1/en unknown
- 1976-03-25 NL NL7603116A patent/NL7603116A/xx unknown
- 1976-03-25 NO NO761052A patent/NO761052L/no unknown
- 1976-03-26 LU LU74651A patent/LU74651A1/xx unknown
- 1976-03-26 DD DD192069A patent/DD124601A5/xx unknown
- 1976-03-26 PT PT64951A patent/PT64951B/pt unknown
- 1976-03-26 FR FR7608977A patent/FR2305186A1/fr active Granted
- 1976-03-26 SE SE7603699A patent/SE7603699L/xx unknown
- 1976-03-26 JP JP51033472A patent/JPS51138694A/ja active Pending
- 1976-03-29 AU AU12442/76A patent/AU1244276A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI760793A7 (cg-RX-API-DMAC7.html) | 1976-09-28 |
| DD124601A5 (cg-RX-API-DMAC7.html) | 1977-03-02 |
| NL7603116A (nl) | 1976-09-29 |
| FR2305186B1 (cg-RX-API-DMAC7.html) | 1980-07-04 |
| IE43541B1 (en) | 1981-03-25 |
| NO761052L (cg-RX-API-DMAC7.html) | 1976-09-28 |
| DK132876A (da) | 1976-09-28 |
| PT64951A (en) | 1976-04-01 |
| LU74651A1 (cg-RX-API-DMAC7.html) | 1977-10-10 |
| FR2305186A1 (fr) | 1976-10-22 |
| IE43541L (en) | 1976-09-27 |
| JPS51138694A (en) | 1976-11-30 |
| PT64951B (en) | 1977-08-26 |
| SE7603699L (sv) | 1976-09-28 |
| AU1244276A (en) | 1977-10-06 |
| IL49183A0 (en) | 1976-05-31 |
| DE2612760A1 (de) | 1976-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES378765A1 (es) | Un procedimiento para la preparacion de cefalosporinas de 3-mercaptotiazol o mercaptotetrazol. | |
| PH21545A (en) | Novel penicillins and pharmaceutically acceptable salts thereof which contain a mono- or di- oxo piperazino (thio)-carbonyl amino group in molecule | |
| ES446571A1 (es) | Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. | |
| GB1513824A (en) | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative | |
| GB1266769A (cg-RX-API-DMAC7.html) | ||
| GB1456221A (en) | 3-hydroxy cephalosporins their ether derivatives and methods for their preparation | |
| ES412859A1 (es) | Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina. | |
| GB1289358A (cg-RX-API-DMAC7.html) | ||
| ES266444A1 (es) | Procedimiento de obtenciën de derivados de caphalosporina c y de sus compuestos | |
| ES446353A1 (es) | Procedimiento para preparar cefalosporinas. | |
| ES381961A1 (es) | Procedimiento de preparacion de nuevos derivados de acido fenilacetico, racemicos u opticamente activos. | |
| ES393801A1 (es) | Un procedimiento para la preparacion de compuestos semisin-teticos utilizados en la produccion de cefalosporinas, peni-cilinas y compuestos antibioticos relacionados de beta-lac- tama. | |
| ES448721A1 (es) | Un procedimiento para la produccion de compuestos amidicos antibacterianos. | |
| IE43931L (en) | Homophthalimides | |
| GB873049A (en) | Improvements in or relating to penicillin derivatives | |
| SE7600585L (sv) | Forfarande for framstellning av 7-aminocefalosporansyraderivat | |
| ES447615A1 (es) | Un procedimiento para obtener compuesto de cefalosporina. | |
| ES446132A1 (es) | Un procedimiento para la preparacion de nuevos derivados de acido 2-alquil (inferior)-2 o 3-cefem-4-carboxilico. | |
| GB1089215A (en) | New penicillins and process for preparing them | |
| ES438658A1 (es) | Un procedimiento para la preparacion de nuevos derivados de penicilina. | |
| GB1315790A (en) | 3-substituted cephalosporin derivatives and preparation thereof | |
| KR910015586A (ko) | 신규한 세팔로스포린 화합물과 그의 제조방법 | |
| ES452779A1 (es) | Procedimiento para la obtencion de cefaloesporinas. | |
| ES424770A1 (es) | Un procedimiento para la preparacion de nuevos derivados delacido cefalosporanico. | |
| ES443372A1 (es) | Un procedimiento para la preparacion de derivados del acido 3-cefem-4-carboxilico. |