ES446261A1 - Compound and production thereof - Google Patents

Abstract

A procedure for the preparation of diacepinic imidazo [1,5-to 3] [1,4] compounds of the general formula **(See formula)** where A represents -C (R6) = N-; R1 represents hydrogen, lower alkyl, alkoxy-lower alkyl or halo-lower alkyl, R2 represents the group -COOR10 (where R10 represents lower alkyl), R represents hydrogen or lower alkyl; R6 represents phenyl, mono-substituted phenyl, di-substituted phenyl, pyridyl or mono-substituted pyridyl; and **(See formula)** represents the group **(See formula)** where X is hydrogen, chlorine, bromine or iodine, T is hydrogen or lower alkyl, R4 represents hydrogen, halogen, nitro cyano, trifluoro methyl, lower alkyl, substituted amino, anino, hydroxy-lower alkyl or lower alkanoyl and R5 represents hydrogen, and the pharmaceutically acceptable salts of these compounds that in the case of certain compounds of formula I have a structure in which the diacepinic ring is opened or by cleavage of the C/N double bond at position 5, or 6, the procedure of which involves making react a compound of the formula **(See formula)** with an alkanoic acid ortho-ester of the formula R1C (OR) 3, where R is lower alkyl and R1 is hydrogen, lower alkyl, alkoxy-lower alkyl or halo-lower alkyl, or with a respective chemical equivalent to directly obtain a corresponding compound of the formula I, being present during this reaction, any amine or alkylamine group in protected form, if desired, solving a racemic compound of the above formula I in its optical enantiomers, and if desired, converting a compound of formula X above is a pharmacy acceptable salt. (Machine-translation by Google Translate, not legally binding)